Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts

Endocrinology

Volumn 141, Issue 12, 2000, Pages 4558-4563

  Pereira, Renata C ^a   Economides, Aris N ^a,c   Canalis, Ernesto ^a,b  

^a SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^c REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; DNA; FIBROBLAST GROWTH FACTOR 2; GREMLIN; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; POLYPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; NONHUMAN; NORTHERN BLOTTING; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; TIME; WESTERN BLOTTING;

EID: 0034520158     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.12.7851     Document Type: Article

References (43)

1. Identification of transforming growth factor B family members present in bone-inductive protein purified from bovine bone
2. Bone morphogenetic proteins: An update on basic biology and clinical relevance
3. Expression of the BMP 2 gene during bone cell differentiation
4. Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6
5. Bone morphogenetic protein-4 regulates its own expression in cultured osteoblasts
6. The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro
7. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells
8. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts
9. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
10. Reorganizing the organizer 75 years on
11. Identification of mammalian noggin and its expression in the adult nervous system
12. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein-4
13. Dorsoventral patterning in xenopus: Inhibition of ventral signals by direct binding of chordin to BMP-4
14. The Xenopus dorsalizing factor gremlin identifies a novel family of secreted proteins that antagonize BMP activities
15. The head inducer cerberus is a multifunctional antagonist of nodal, BMP and Wnt signals
16. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
17. DAN is a secreted glycoprotein related to Xenopus cerberus
18. Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture
19. Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach
20. A mouse cerberus/dan-related gene family
21. Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: Antagonism by noggin
22. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
23. Further biochemical and molecular characterization of primary rat parietal bone cell cultures
24. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria
25. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
26. Identification of newly transcribed RNA
27. Cleavage of structural protein during the assembly of the head bacteriophage T4
28. Insulin-like growth factor I (IGF-I) has independent effects on bone matrix formation and cell replication
29. Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins
30. Biosynthesis, post-translation modification, and functional characterization of Drm/gremlin
31. Glucocorticoid regulation of transforming growth factor β (TGF β) activity and binding in osteoblast-enriched cultures from fetal rat bone
32. Effects of fibroblast growth factors on deoxyribonucleic acid and collagen synthesis in rat parietal bone cells
33. Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts
34. Skeletal bone morphogenetic proteins suppress the expression of collagenase-3 by rat osteoblasts
35. Insulin-like growth factor binding proteins
36. Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures
37. 2, growth hormone, and the insulin-like growth factors
38. Insulin-like growth factor I and retinoic acid induce the synthesis of insulin-like growth factor binding protein-5 in rat osteoblastic cells
39. Activin-binding protein from rat ovary is follistatin
40. Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin
41. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva
42. Increased expression of TGF-β2 in osteoblasts results in an osteoporosis-like phenotype