Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent

Organic and Biomolecular Chemistry

Volumn 8, Issue 2, 2010, Pages 413-418

  Maroz, Andrej ^a   Shinde, Sujata S ^a,b   Franzblau, Scott G ^c   Ma, Zhenkun ^d   Denny, William A ^b   Palmer, Brian D ^b   Anderson, Robert F ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CANDIDATE DRUGS; CYTOTOXIC; ELECTRON-DONATING SUBSTITUENTS; HIGH YIELD; LOW DIELECTRIC CONSTANTS; MODEL PROTEINS; MYCOBACTERIUM TUBERCULOSIS; NITROIMIDAZOLES; NON-AQUEOUS SOLVENTS; ONE-ELECTRON REDUCTIONS; PROTIC SOLVENTS; RADIOLYTIC REDUCTION; REACTIVE NITROGEN SPECIES; RELATED COMPOUNDS; SCREENING TESTS;

AROMATIC COMPOUNDS; PROTEINS; RADIOLYSIS;

ELECTRONS;

4 NITROBENZONITRILE; 4-NITROBENZONITRILE; 6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; NITRILE; NITRITE; NITROBENZENE DERIVATIVE; NITROIMIDAZOLE DERIVATIVE; REACTIVE NITROGEN SPECIES; SOLVENT; TUBERCULOSTATIC AGENT; WATER;

AEROBIC METABOLISM; ANOXIA; ARTICLE; CHEMISTRY; DRUG EFFECT; ELECTRON TRANSPORT; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; PULSE RADIOLYSIS; ULTRAVIOLET SPECTROPHOTOMETRY;

AEROBIOSIS; ANOXIA; ANTITUBERCULAR AGENTS; ELECTRON TRANSPORT; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NITRILES; NITRITES; NITROBENZENES; NITROIMIDAZOLES; PULSE RADIOLYSIS; REACTIVE NITROGEN SPECIES; SOLVENTS; SPECTROPHOTOMETRY, ULTRAVIOLET; WATER;

MYCOBACTERIUM TUBERCULOSIS;

EID: 72949083267     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b915877d     Document Type: Article

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