The emerging role of SOX transcription factors in pancreatic endocrine cell development and function

Stem Cells and Development

Volumn 18, Issue 10, 2009, Pages 1379-1387

  McDonald, Erin ^a   Krishnamurthy, Mansa ^a   Goodyer, Cynthia G ^b   Wang, Rennian ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROGENIN 3; TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX 13; TRANSCRIPTION FACTOR SOX 14; TRANSCRIPTION FACTOR SOX 15; TRANSCRIPTION FACTOR SOX 30; TRANSCRIPTION FACTOR SOX1; TRANSCRIPTION FACTOR SOX10; TRANSCRIPTION FACTOR SOX11; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX18; TRANSCRIPTION FACTOR SOX4; TRANSCRIPTION FACTOR SOX5; TRANSCRIPTION FACTOR SOX6; TRANSCRIPTION FACTOR SOX7; TRANSCRIPTION FACTOR SOX8; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

BONE; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL MATURATION; CELL PROLIFERATION; CELL STRUCTURE; EMBRYO DEVELOPMENT; ENDOCRINE CELL; GENE EXPRESSION; GENE OVEREXPRESSION; GLIA CELL; GONAD; HEART; HUMAN; LYMPHOCYTE; MORPHOGENESIS; NONHUMAN; ORGANOGENESIS; PANCREAS; PANCREAS ISLET; PANCREAS ISLET CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REVIEW; STEM CELL;

ANIMALS; ENDOCRINE GLANDS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; PANCREAS; SOX TRANSCRIPTION FACTORS;

EID: 72849146679     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2009.0240     Document Type: Review

References (46)

1. Sander M and MS German. (1997). The beta cells transcription factors and development of the pancreas. J Mol Med 75:327-340.
2. Kim SK and M Hebrok. (2001). Intercellular signals regulating pancreas development and function. Genes Dev 15:111-127.
3. Chakrabarti SK and RG Mirmira. (2003). Transcription factors direct the development and function of pancreatic beta cells. Trends Endocrinol Metab 14:78-84.
4. Lioubinski O, M Muller, M Wegner and M Sander. (2003). Expression of sox transcription factors in the developing mouse pancreas. Dev Dyn 227:402-408.
5. Lyttle BM, J Li, M Krishnamurthy, F Fellows, MB Wheeler, CG Goodyer and R Wang. (2008). Transcription factor expression in the developing human fetal endocrine pancreas. 51(7):1169-1180.
6. Jensen J. (2004). Gene regulatory factors in pancreatic development. Dev Dyn 229:176-200.
7. Habener JF, DM Kemp and MK Thomas. (2005). Minireview: transcriptional regulation in pancreatic development. Endocrinology 146:1025-1034.
8. Slack JM. (1995). Developmental biology of the pancreas. Development 121:1569-1580.
9. Teitelman G, S Alpert, JM Polak, A Martinez and D Hanahan. (1993). Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 118:1031-1039.
10. Piper K, S Brickwood, LW Turnpenny, IT Cameron, SG Ball, DI Wilson and NA Hanley. (2004). Beta cell differentiation during early human pancreas development. J Endocrinol 181:11-23.
11. Huang HP and MJ Tsai. (2000). Transcription factors involved in pancreatic islet development. J Biomed Sci 7:27-34.
12. Cerf ME. (2006). Transcription factors regulating beta-cell function. Eur J Endocrinol 155:671-679.
13. Gu G, J Dubauskaite and DA Melton. (2002). Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457.
14. Offield MF, TL Jetton, PA Labosky, M Ray, RW Stein, MA Magnuson, BL Hogan and CV Wright. (1996). PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995.
15. Gradwohl G, A Dierich, M LeMeur and F Guillemot. (2000). Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611.
16. Wilson ME, KY Yang, A Kalousova, J Lau, Y Kosaka, FC Lynn, J Wang, C Mrejen, V Episkopou, HC Clevers and MS German. (2005). The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas. Diabetes 54:3402-3409.
17. Seymour PA, KK Freude, MN Tran, EE Mayes, J Jensen, R Kist, G Scherer and M Sander. (2007). SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci USA 104:1865-1870.
18. Lynn FC, SB Smith, ME Wilson, KY Yang, N Nekrep and MS German. (2007). Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci USA 104:10500-10505.
19. Gubbay J, J Collignon, P Koopman, B Capel, A Economou, A Munsterberg, N Vivian, P Goodfellow and R Lovell-Badge. (1990). A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346:245-250.
20. Schepers GE, RD Teasdale and P Koopman. (2002). Twenty pairs of sox: Extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. Dev Cell 3:167-170.
21. Wilson M and P Koopman. (2002). Matching SOX: Partner proteins and co-factors of the SOX family of transcriptional regulators. Curr Opin Genet Dev 12:441-446.
22. Laudet V, D Stehelin and H Clevers. (1993). Ancestry and diversity of the HMG box superfamily. Nucleic Acids Res 21:2493-2501
23. Soullier S, P Jay, F Poulat, JM Vanacker, P Berta and V Laudet. (1999). Diversification pattern of the HMG and SOX family members during evolution. J Mol Evol 48:517-527.
24. Bowles J, G Schepers and P Koopman. (2000). Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev Biol 227:239-255.
25. Lefebvre V, B Dumitriu, A Penzo-Méndez, Y Han and B Pallavi. (2007). Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol 39:2195-2214.
26. Wegner M. (1999). From head to toes: the multiple facets of sox proteins. Nucleic Acids Res 27:1409-1420.
27. Weiss MA. (2001). Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition. Mol Endocrin 15:353-362.
28. Pevny LH and R Lovell-Badge. (1997). Sox genes find their feet. Curr Opin Genet Dev 7:338-344.
29. Kamachi Y, M Uchikawa and H Kondoh. (2000). Pairing SOX off: with partners in the regulation of embryonic development. Trends Genet 16:182-187.
30. Iguchi H, Y Ikeda, M Okamura, T Tanaka, Y Urashima, H Ohguchi, S Takayasu, N Kojima, S Iwasaki, R Ohashi, S Jiang, G Hasegawa, RX Ioka, K Magoori, K Sumi, T Maejima, A Uchida, M Naito, TF Osbourne, M Yanagisawa, TT Yamamoto, T Kodama and J Sakai. (2005). SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. J Biol Chem 280:37669-37680.
31. Piper K, SG Ball, JW Keeling, S Mansoor, DI Wilson and NA Hanley. (2002). Novel SOX9 expression during human pancreas development correlates to abnormalities in campomelic dysplasia. Mech Dev 116:223-226.
32. Wang Y, S Ristevski and VR Harley. (2006). SOX13 exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis, and limb development. J Histochem Cytochem 54:1327-1333.
33. Zhao M, SA Amiel, MR Christie, P Muiesan, P Srinivasan, W Littlejohn, M Rela, M Arno, N Heaton and GC Huang. (2007). Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J Endocrinol 195:407-414.
34. Hoser M, MR Potzner, JM Koch, MR Bösl, M Wegner and E Sock. (2008). Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol 28:4675-4687.
35. Schilham MW, MA Oosterwegel, P Moerer, J Ya, PA de Boer, M van de Wetering, S Verbeek, WH Lamers, AM Kruibeek, A Cumano and H Clevers. (1996). Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature 380:711-714.
36. Sock E, SD Rettig, J Enderich, MR Bösl, ER Tamm and M Wegner. (2004). Gene targeting reveals a widespread role for the highmobility- group transcription factor Sox11 in tissue remodeling. Mol Cell Biol 24:6635-6644.
37. Goldsworthy M, A Hugill, H Freeman, E Horner, K Shimomura, D Bogani, G Pieles, V Mijat, R Arkell, S Bhattacharya, FM Ashcroft and RD Cox. (2008). Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57:2234-2244.
38. Kasimiotis H, MA Myers, A Argentaro, S Mertin, S Fida, T Ferraro, J Olsson, MJ Rowley and VR Harley. (2000). Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets. Diabetes 49:555-561.
39. Argentaro A, B Wapelhorst, P Concannon and VR Harley. (2001). Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes. Mol Genet Metab 72:356-359
40. Lampasona V, M Scirpoli, E Bosi and E Bonifacio E. (2001). ICA12 (SOX13) autoantibodies are unlikely to be a useful marker for pre-clinical Type I diabetes. Diabetologia 44:267.
41. Iguchi H, Y Urashima, Y Inagaki, Y Ikeda, M Okamura, T Tanaka, A Uchida, TT Yamamoto, T Kodama and J Sakai. (2007). SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferation. J Biol Chem 282:19052-19061.
42. McDonald E, J Li, F Fellows, CG Goodyear and R Wang. (2008). Role of SOX9 in endocrine cell differentiation in the human fetal pancreas. Can. J Diabetes Care 32:4.
43. Lee YH and JP Saint-Jeannet. (2003). Sox9, a novel pancreatic marker in Xenopus. Int J Dev Biol 47:459-462.
44. Seymour PA, KK Freude, CL Dubois, HP Shih, NA Patel and M Sander. (2008). A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol 323:19-30.
45. Kanai-Azuma M, Y Kanai, JM Gad, Y Tajima, C Taya, M Kurohmaru, Y Sanai, H Yonekawa, K Yazaki, PP Tam and Y Hayashi. (2002). Depletion of definitive gut endoderm in Sox17- null mutant mice. Development 129:2367-2379.
46. Spence JR, AW Lange, SC Lin, KH Kaestner, AM Lowy, I Kim, JA Whitsett and JM Wells. (2009). Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17:62-74.