SOX6 suppresses cyclin D1 promoter activity by interacting with β-catenin and histone deacetylase 1, and its down-regulation induces pancreatic β-cell proliferation

Journal of Biological Chemistry

Volumn 282, Issue 26, 2007, Pages 19052-19061

  Iguchi, Haruhisa ^a,b,d   Urashima, Yasuyo ^a   Inagaki, Yosuke ^c   Ikeda, Yukio ^b   Okamura, Masashi ^a   Tanaka, Toshiya ^a   Uchida, Aoi ^a   Yamamoto, Tokuo T ^c   Kodama, Tatsuhiko ^a   Sakai, Juro ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENE EXPRESSION; GLUCOSE; HISTOLOGY; INSULIN; RNA;

HISTONE; INSULIN SECRETION; RETROVIRAL OVEREXPRESSION;

ENZYME ACTIVITY;

BETA CATENIN; CYCLIN D1; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H4; INSULIN; LUCIFERASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SOX6;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; INSULINOMA; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RETROVIRUS;

ANIMALS; BETA CATENIN; CELL DIVISION; CELL LINE, TUMOR; CYCLIN D1; DNA-BINDING PROTEINS; DOWN-REGULATION; HIGH MOBILITY GROUP PROTEINS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INSULINOMA; KIDNEY; LEUCINE ZIPPERS; MICE; NIH 3T3 CELLS; OBESITY; PANCREATIC NEOPLASMS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RATS; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC;

ARMADILLO; MUS;

EID: 34547129844     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700460200     Document Type: Article

References (26)

1. Butler, A. E., Janson, J., Soeller, W. C., and Butler, P. C. (2003) Diabetes 52, 2304-2314
2. Rhodes, C. J. (2005) Science 307, 380-384
3. Iguchi, H., Ikeda, Y., Okamura, M., Tanaka, T., Urashima, Y., Ohguchi, H., Takayasu, S., Kojima, N., Iwasaki, S., Ohashi, R., Jiang, S., Hasegawa, G., Ioka, R. X., Magoori, K., Sumi, K., Maejima, T., Uchida, A., Naito, M., Osborne, T. F., Yanagisawa, M., Yamamoto, T. T., Kodama, T., and Sakai, J. (2005) J. Biol. Chem. 280, 37669-37680
4. Kulkarni, R. N., Jhala, U. S., Winnay, J. N., Krajewski, S., Montminy, M., and Kahn, C. R. (2004) J. Clin. Investig. 114, 828-836
5. Schepers, G. E., Teasdale, R. D., and Koopman, P. (2002) Dev. Cell 3, 167-170
6. Lefebvre, V., Li, P., and de Crombrugghe, B. (1998) EMBO J. 17, 5718-5733
7. Smits, P., Li, P., Mandel, J., Zhang, Z., Deng, J. M., Behringer, R. R., de Crombrugghe, B., and Lefebvre, V. (2001) Dev. Cell 1, 277-290
8. Ikeda, Y., Yamamoto, J., Okamura, M., Fujino, T., Takahashi, S., Takeuchi, K., Osborne, T. F., Yamamoto, T. T., Ito, S., and Sakai, J. (2001) J. Biol. Chem. 276, 34259-34269
9. Yamamoto, J., Ikeda, Y., Iguchi, H., Fujino, T., Tanaka, T., Asaba, H., Iwasaki, S., Ioka, R. X., Kaneko, I. W., Magoori, K., Takahashi, S., Mori, T., Sakaue, H., Kodama, T., Yanagisawa, M., Yamamoto, T. T., Ito, S., and Sakai, J. (2004) J. Biol. Chem. 279, 16954-16962
10. Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S. C., Iguchi, H., Kawasawa, Y. I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R. X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M., and Sakai, J. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 7438-7443
11. Kitamura, T. (1998) Int. J. Hematol. 67, 351-359
12. Morita, S., Kojima, T., and Kitamura, T. (2000) Gene Ther. 7, 1063-1066
13. Sakai, J., Nohturfft, A., Goldstein, J. L., and Brown, M. S. (1998) J. Biol. Chem. 273, 5785-5793
14. Fujino, T., Asaba, H., Kang, M. J., Ikeda, Y., Sone, H., Takada, S., Kim, D. H., Ioka, R. X., Ono, M., Tomoyori, H., Okubo, M., Murase, T., Kamataki, A., Yamamoto, J., Magoori, K., Takahashi, S., Miyamoto, Y., Oishi, H., Nose, M., Okazaki, M., Usui, S., Imaizumi, K., Yanagisawa, M., Sakai, J., and Yamamoto, T. T. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 229-234
15. Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., Watanabe, Y., Uchiyama, Y., Sumi, K., Iguchi, H., Ito, S., Doi, T., Hamakubo, T., Naito, M., Auwerx, J., Yanagisawa, M., Kodama, T., and Sakai, J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 15924-15929
16. Sambrook, J., and Russell, D. W. (2001) Molecular Cloning: A Laboratory Manual, 3rd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
17. Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D'Amico, M., Pestell, R., and Ben-Ze'ev, A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 5522-5527
18. Tetsu, O., and McCormick, F. (1999) Nature 398, 422-426
19. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. (1997) Science 275, 1784-1787
20. Akiyama, H., Lyons, J. P., Mori-Akiyama, Y., Yang, X., Zhang, R., Zhang, Z., Deng, J. M., Taketo, M. M., Nakamura, T., Behringer, R. R., McCrea, P. D., and de Crombrugghe, B. (2004) Genes Dev. 18, 1072-1087
21. Coates, J. C. (2003) Trends Cell Biol. 13, 463-471
22. Ayer, D. E. (1999) Trends Cell Biol. 9, 193-198
23. Johnstone, R. W. (2002) Nat. Rev. Drug. Discov. 1, 287-299
24. Huelsken, J., and Birchmeier, W. (2001) Curr. Opin. Genet. Dev. 11, 547-553
25. Logan, C. Y., and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810
26. Dor, Y., Brown, J., Martinez, O. I., and Melton, D. A. (2004) Nature 429, 41-46