Defining the role of HIF-1α and CTGF in fibrosis

46th Annual Rocky Mountain Bioengineering Symposium and 46th International ISA Biomedical Sciences Instrumentation Symposium 2009

Volumn 476, Issue , 2009, Pages 340-345

  Haung, Derek ^a   Adah, Ameze ^a   Richardson, Rhea ^a   Pierce, Christine ^a   Whittington, Alex ^a   Taylor, Tamika ^a   Tucci, Michelle ^a   Benghuzzi, Ham ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

CTGF; Fibrosis; Fructose 1,6 bisphosphate; HIF 1 ; Hypoxia; MRC5

Indexed keywords

BISPHOSPHATES; CELLULAR STAINING; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST CELLS; FIBROSIS; HYPOXIC CONDITION; MECHANISM OF ACTION; MYOFIBROBLASTS; STRONG CORRELATION; TISSUE DAMAGE; TISSUE HYPOXIA;

CELL CULTURE; FRUCTOSE; INSTRUMENTS; LANDFORMS; MUSCULOSKELETAL SYSTEM; TISSUE;

FIBROBLASTS;

EID: 72849140156     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (18)

1. Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab. 2000 Sep-Oct;71(1-2):276-92.
2. Guo LP, Huang HC, Li JZ. Hypoxia induces the expression and secretion of connective tissue growth factor and fibronectin by cultured renal cortical myofibroblasts. Beijing Da Xue Xue Bao. 2007 Feb 18;39(1):67-71.
3. Rong LL, Huang HC, Yu L, Li JZ. Hypoxia stimulates expression of connective tissue growth factor through p38 signaling pathway in human renal interstitial fibroblasts. Beijing Da Xue Xue Bao. 2005 Aug 18;37(4):378-81.
4. Hong KH, Yoo SA, Kang SS, Choi JJ, Kim WU, Cho CS. Hypoxia induces expression of connective tissue growth factor in scleroderma skin fibroblasts. Clin Exp Immunol. 2006 Nov;146(2):362-70.
5. Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. Hypoxic induction of Ctgf is directly mediated by Hif-1. Am J Physiol Renal Physiol. 2004 Dec;287(6):F1223-32. Epub 2004 Aug 17.
6. Hardin CD and T. M. Roberts. Metabolism of exogenously applied fructose 1.6-bisphosphate in hypoxic vascular smooth muscle. American Physiological Society.
7. Nakai T Tanimura H, Tabuse K, Nagai Y, Mori K, Yamoto H.. Beneficial effects of fructose-1,6-diphosphate infusion on liver regeneration after ischemic liver injury. Gastroenterol Jpn. 1991 Oct;26(5):611-8.
8. Morikawa S Santos RC, Alves-Filho JC, Oliveria JR.. Glucose and energy metabolism in rat liver after ischemic damage assessed by 13 C and 31 P NMR spectroscopy. J Surg Res. 1996 Jul 1;63(2):393-9.
9. Riedel BJ Gal J, Ellis G, Marangos PJ, Fox AW, Royston D. Myocardial protection using fructose-1,6-diphosphate during coronary artery bypass graft surgery: a randomized, placebo-controlled clinical trial. Anesth Analg. 2004 Jan;98(1):20-9.
10. Long J, Zhang Z, Li X. The protective mechanism of fructose-1, 6-diphosphate on ischemic brain injury. Zhonghua Yi Xue Za Zhi. 2002 Feb 25;82(4):232-5.
11. Moresco RN et al. Effect of fructose-1,6-bisphosphate in the cold storage solution after 12 and 36 hours of rat liver preservation. Transplant Proc. 2004 Nov;36(9):2593-5.
12. Ehringer WD Niu W, Chiang B, Wang OL, Gordon L, Chien S.. Membrane permeability of fructose-1,6-diphosphate in lipid vesicles and endothelial cells. Mol Cell Biochem. 2000 Jul;210(1-2):35-45.
13. Cui MX, Chen XL, Huo CL, Hu XJ, Ai J. Expression of connective tissue growth factor in pulmonary artery at the early-stage of pulmonary fibrosis. Sheng Li Xue Bao. 2008 Aug 25;60(4):535-40.
14. Bogatkevich GS, Ludwicka-Bradley A, Singleton CB, Bethard JR, Silver RM. Proteomic analysis of CTGF-activated lung fibroblasts: identification of IQGAP1 as a key player in lung fibroblast migration. Am J Physiol Lung Cell Mol Physiol. 2008 Aug 1.
15. Adah A, Benghuzzi H, Tucci M, Huang D, Franklin L, Adah F. Metabolic effects of fructose 1,6-bisphosphate in normoxic and hypoxic states of MG63 osteosarcoma cells. Biomed Sci Instrum. 2006;42:120-5.
16. Vexler ZC, Wong A, Franciso C, Manabat C, Christen S, Tauber M, Ferriero DM, and Gregory G. Fructose-1,6-bisphosphate preserves intracellular glutathione and protects against oxidative stress. Brain Res. 2003, Jan 17; 960 (1,2): 90-8.
17. Fan J, Cai H, Yang S, Yan L, Tan W. Comparison between the effects of normoxia and hypoxia on antioxidant enzymes and glutathione redox state ex-vivo culture of CD34(+) cells. Com Biochem Physiol B Biochem Mol Biol 2008 Oct; 151(2):153-8.
18. Yumei F, Zhou Y, Zheng S, Chen A. Lab Invest. 2006 Jul;86(7):697-709.