Neurotoxic and cytotoxic effects of venom from different populations of the Egyptian Scorpio maurus palmatus

Toxicon

Volumn 55, Issue 2-3, 2010, Pages 298-306

  Abdel Rahman, Mohamed A ^a   Omran, Mohamed Alaa A ^a,b   Abdel Nabi, Ismail M ^a   Nassier, Omimah A ^c   Schemerhorn, Brandon J ^d  

^a Suez Canal University   (Egypt)

^b TAIF UNIVERSITY   (Saudi Arabia)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Bioinsecticides; Egypt; Oxidative stress; PED50; Scorpio maurus palmatus; Venom diversity

Indexed keywords

CARBONYL DERIVATIVE; CATALASE; CHOLINESTERASE; GLUTATHIONE; LIPID; NITRIC OXIDE; SCORPION VENOM; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COCKROACH; CONTROLLED STUDY; CYTOTOXICITY TEST; DESERT; DISABILITY; EGYPT; ENZYME ACTIVITY; FEMALE; FLACCID PARALYSIS; GEOGRAPHICAL VARIATION (SPECIES); INSECTICIDAL ACTIVITY; LIPID PEROXIDATION; LONG TERM EXPOSURE; MICROINJECTION; NEUROTOXICITY; NONHUMAN; POPULATION DIFFERENTIATION; PRIORITY JOURNAL; SCORPION; SEMIARID CLIMATE; SPASTICITY;

ANIMALS; BEHAVIOR, ANIMAL; CATALASE; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; CYTOTOXINS; EGYPT; GLUTATHIONE; INSECTICIDES; MALONDIALDEHYDE; NEUROTOXINS; NITRIC OXIDE; OXIDATION-REDUCTION; PERIPLANETA; PROTEIN CARBONYLATION; SCORPION VENOMS; SPECIES SPECIFICITY; SUPEROXIDE DISMUTASE;

BLATTARIA; HEXAPODA; SCORPIO MAURUS PALMATUS; SCORPIONES;

EID: 72749108858     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.08.003     Document Type: Article

References (77)

1. Abdel-Rahman M.A. Intraspecific diversity of scorpions' venom and its implication on the pathophysiological effects. J. Venom. Anim. Toxins Incl. Trop. Dis. 14 1 (2008) 191-192 Thesis
2. Abdel-Rahman M.A., Abdel-Nabi I.M., Omran M.A., and Moustafa F. Cytotoxic effects of albendazole, an antiparasitic drug, on the liver of the rat: subchronic study. Egyptian Journal of Biology 1 (1999) 16-29
3. Abdel-Rahman M.A., Omran M.A., Abdel-Nabi I.M., Ueda H., and McVean A. Intraspecific diversity in the Egyptian scorpion Scorpio maurus palmatus venom collected from different biotopes. Toxicon 53 3 (2009) 349-359
4. Aebi H. Catalase. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analyses (1974), Academic Press, New York 673-683
5. Albrecht G.H. Multivariate analysis and the study of form, with special reference to canonical variate analysis. Am. Zool. 20 (1980) 679-693
6. Avdonin V., Nolan B., Sabatier J., De Waard M., and Hoshi T. Mechanisms of maurotoxin action on Shaker potassium channels. Biophys. J. 79 (2000) 776-787
7. Barros S.F., Friedlanskaia I., Petricevich V.L., and Kipnis T. Local inflammation, lethality and cytokine release in mice injected with Bothrops atrox venom. Mediators Inflamm 7 5 (1998) 339-346
8. Bauer G. Reactive oxygen and nitrogen species: efficient, selective, and interactive signals during intercellular induction of apoptosis. Anticancer Res. 20 (2000) 4115-4139
9. Becker L.B., van den Hoek T.L., Shao Z.H., Li C.Q., and Schumacker P.T. Generation of superoxide in cardiomyocytes during ischemia before reperfusion. Am. J. Physiol 277 (1999) H2240-H2246
10. Ben Khalifa R., Stankiewicz M., Lapied B., Turkov M., Zilberberg N., Gurevitz M., and Pelhate M. Refined electrophysiological analysis suggests that a depressant toxin is a sodium channel opener rather than a blocker. Life Sci. 61 (1997) 819-830
11. Beutler E., Doron O., and Kelly B. Improved method for the determination of blood glutathione. J. Lab. Clin. Med. 61 5 (1963) 882-888
12. Boisseau S., Mabrouk K., Ram N., Garmy N., Collin V., Tadmouri A., Mikati M., Sabatier J., Ronjat M., Fantini J., and De Waard M. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim. Biophys. Acta 1758 (2006) 308-319
13. Borges A., Garci{dotless}a C., Lugo E., Alfonso M., Jowers M., and Op den Camp H. Diversity of long-chain in Tityus zulianus and Tityus discrepans (Scorpiones, Buthidae): molecular, immunological, and mass spectral analyses. Comp. Biochem. Physiol 142C (2006) 240-252
14. Butterfield D.A., and Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech. Ageing Dev. 122 (2001) 945-962
15. + channels. J. Pept. Res. 55 (2000) 419-427
16. 2+-activated potassium channels. Mol. Pharmacol 63 (2003) 409-418
17. Cohen L., Gilles N., Karbat I., Ilan N., Gordon D., and Gurevitz M. Direct evidence that receptor site-4 of sodium channel gating modifiers is not dipped in the phospholipid bilayer of neuronal membranes. J. Biol. Chem. 281 (2006) 20673-20679
18. Darbon H., Zlotkin E., Kopeyan C., Van Rietschoten J., and Rochat H. Covalent structure of the insect toxin of the North African scorpion Androctonus australis Hector. Int. J. Pept. Prot. Res. 20 (1982) 320-330
19. Dyason K., Brandt W., Prendini L., Verdonck F., Tytgat J., du Plessis J., Muller G., and van der Walt J. Determination of species-specific components in the venom of Parabuthus scorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 16 8 (2002) 768-773
20. El Ayeb M., and Rochat H. Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis hector. Toxicon 23 (1985) 755
21. El-Hafny B., Chgoury F., Adil N., Chen N., and Nassar M. Intraspecific variability and pharmacokinetics, characteristics of Androctonus mauretanicus scorpion venom. Toxicon 40 11 (2002) 1609-1616
22. Ellman C.L., Courtney D., Andres V., and Featherstone R. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7 (1961) 8895
23. 2+ release efficacy of maurocalcine in skeletal muscle cell. J. Biol. Chem. 278 (2003) 37822-37831
24. Feng L., Gao R., and Gopalakrishnakone P. Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2008) 250-257
25. Finney D.J. Probit Analysis. third ed. (1971), Cambridge University Press, Cambridge, UK
26. Fishman L., Herrmann R., Gordon D., and Zlotkin E. Insect tolerance to a neurotoxic polypeptide: pharmacokinetic and pharmacodynamic aspects. J. Exp. Biol. 200 (1997) 1115-1123
27. Froy O., Zilberberg N., Gordon D., Turkov M., Gilles N., Stankiewicz M., Pelhate M., Loret E., Oren D.A., Shaanan B., and Gurevitz M. The putative bioactive surface of insect-selective scorpion excitatory neurotoxins. J. Biol. Chem. 274 (1999) 5769-5776
28. Gordon D. A new approach to insect-pest control - combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity. Invert. Neurosci 3 (1997) 103-116
29. Gordon D., Ilan N., Zilberberg N., Gilles N., Urbach1 D., Cohen L., Karbat I., Froy O., Gaathon A., Kallen R., Benveniste M., and Gurevitz M. An 'Old World' scorpion β-toxin that recognizes both insect and mammalian sodium channels. Eur. J. Biochem 270 (2003) 2663-2670
30. Goudet C., Chi C., and Tytgat J. An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon 40 (2002) 1239-1258
31. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal. Biochem 126 (1982) 131-138
32. Gurevitz M., Karbat I., Cohen L., Ilan N., Kahn R., Turkov M., Stankiewicz M., Stühmer W., Dong K., and Gordon D. The insecticidal potential of scorpion β-toxins. Toxicon 49 (2007) 473-489
33. Gurevitz M., Froy O., Zilberberg N., et al. Sodium channel modifiers from scorpion venom. Structure-activity relationship, mode of action and application. Toxicon 36 (1998) 1671-1682
34. Hog N., and Kalyanaraman B. Nitric oxide and low-density lipoproteinoxidation. Free Radic. Res. 28 (1998) 593-600
35. Kalapothakis E., and Chavez-Olortegui C. Venom variability among several Tityus serrulatus specimens. Toxicon 35 10 (1997) 1523-1529
36. Kanoo S., and Deshpande S.B. Involvement of phospholipase A2 pathway for the Indian red scorpion venom-induced augmentation of cardiopulmonary reflexes elicited by phenyldiguanide. Neurosci. Lett. 440 (2008) 242-245
37. Karbat I., Turkov M., Cohen L., Kahn R., Gordon D., Gurevitz M., and Frolow F. X-ray structure and mutagenesis of the scorpion depressant toxin LqhIT2 reveals key determinants crucial for activity and anti-insect selectivity. J. Mol. Biol. 366 2 (2007) 586-601
38. Klaassen C.D., and Watkins J.B. Toxic responses of the heart and vascular systems. Casarett and Doull's Toxicology. The Basic Science of Poisons. fifth ed. (1999), McGraw-Hill Companies, USA 398-440
39. Kopeyan C., Mansuelle P., Sampieri F., Brando T., Bahraoui E.M., Rochat H., and Granier C. Primary structure of anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus. FEBS Lett. 26 (1990) 423-426
40. Lazarovici P., Yanai P., Pelhate M., and Zlotkin E. Insect toxic components from the venom of a chactoid scorpion, Scorpio maurus palmatus (Scorpionidae). J. Biol. Chem- 257 (1982) 8397-8404
41. Levy G., and Amitai P. Scorpiones. Fauna Palaestina. Arachnida vol. I (1980), Israel Academy of Science and Humanities, Jerusalem 130 pp.
42. Loret E., and Hammock B. Structure and neurotoxicity of venoms. In: Brownell P., and Polis G. (Eds). Scorpion Biology and Research (2001), Oxford University Press, Inc., New York 204-233
43. Martin Eauclaire M., and Couraud F. Scorpion neurotoxins: effects and mechanisms. In: Chang L.W., and Dyer R.S. (Eds). Handbook of Neurotoxicology (1995), Marcell and Dekker, New York 683-716
44. Martin M.F., Rochat H., Marchot P., and Bougis P.E. Use of high performance liquid chromatography to demonstrate quantitative variation in components of venom from the scorpion Androctonus australis hector. Toxicon 25 5 (1987) 569-573
45. McCord J.M. The evolution of free radicals and oxidative stress. Am. J. Med 108 (2000) 652-659
46. Misra H.P., and Firdovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247 (1972) 3170-3175
47. Misra H., and Gorsky L. Paraquat and NADPH-dependent lipid peroxidation in lung microsomes. J. Bio. Chem. 256 (1981) 9994-9998
48. Newton K.A., Clench M.R., Deshmukh R., Jeyaseelan K., and Strong P.N. Mass fingerprinting of toxic fractions from the venom of the Indian red scorpion, Mesobuthus tamulus: biotope-specific variation in the expression of venom peptides. Rapid. Commun. Mass. Spectrom 21 (2007) 3467-3476
49. Nordberg J., and Arner J. Reactive oxygen species antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med 31 11 (2001) 1287-1312
50. Omran M., and McVean A. Intraspecific variation in scorpion Leiurus quinquestriatus venom collected from Egypt (Sinai and Aswan deserts). Toxicol. - Toxin Reviews 19 3 & 4 (2000) 247-264
51. Pappano A. Cholinoceptor-activating and cholinesterase-inhibiting drugs. In: Katzung B. (Ed). Basic and Clinical Pharmacology (2001), The McGraw-Hill Companies, Inc. 93-94
52. Pelhate M., and Zlotkin E. Actions of insect toxin and other toxins derived from the venom of the scorpion Androctonus australis on the isolated giant axons of the cockroach (Periplaneta americana). J. Exp. Biol. 97 (1982) 67-71
53. Pimenta A.M., De Marco Almeida F., Delima M.E., Martin Eauclaire M.E., and Bougis P.E. Individual variability in Tityus serrulatus (Scorpiones, Buthidae) venom elicited by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 17 5 (2003) 413-418
54. 2+ release in the presence of maurocalcine in skeletal muscle. Biophys. J. 91 (2006) 2206-2215
55. Rakhit R.D., Mojet M.H., Marber M.S., and Duchen M.R. Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes. Circulation 103 (2001) 2617-2623
56. Regev A., Rivkin H., Inceoglu B., Gershburg E., Hammock B.D., Gurevitz M., and Chejanovsky N. Further enhancement of baculovirus insecticidal efficacy with scorpion toxins that interact cooperatively. FEBS lett 537 1-3 (2003) 106-110
57. Reznick A.Z., and Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Meth. Enzymol 233 (1994) 357-363
58. Rodriguez-de-la-Vega R., and Possani L.D. Current views on scorpion toxins specific for K(+)-channels. Toxicon 43 (2004) 865-875
59. Rubbo H., Radi R., Anselmi D., Kirk M., Barnes S., Butler J., Eiserich J.P., and Freeman B.A. Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alphatocopherol than alpha-tocopherol/ascorbate. J. Biol. Chem. 275 (2000) 10812-10818
60. Ryan M., and Byrne O. Plant-insect coevolution and inhibition of acetylcholinesterase. J. Chem. Ecol 14 10 (1988) 1965-1975
61. Schild L., Reinheckel T., Reiser M., Horn T.F., Wolf G., and Augustin W. Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. FASEB J. 17 (2003) 2194-2201
62. Snedecor G.W. Statistical Methods. fourth ed. (1956), The Iowa Collage Press, Iowa State, USA
63. Sohal R., Donato H., and Behl E. Effect of age and metabolic rate on lipid peroxidation in the housefly Musca domestica. Mech. Ageing Dev. 16 (1981) 159-167
64. Stewart L., Hirst M., Ferber M., Merryweather A., Cayley P., and Possee R.D. Construction of an improved baculovirus insecticide containing an insect-specific toxin gene. Nature 352 (1991) 85-88
65. Strugatsky D., Zilberberg N., Stankiewicz M., Ilan N., Turkov M., Cohen L., Pelhate N., Gilles M., Gordon D., and Gurevitz M. Genetic polymorphism and expression of a highly potent scorpion depressant toxin enables refinement of the effects on insect Na-channels and illuminates the key role of Asn-58. Biochemistry 44 (2005) 9179-9187
66. Tambourgi D., Petricevich V., Magnoli F., Assaf S., Jancar S., and Dias Da Silva W. Endotoxemic-like shock induced by Loxosceles spider venoms: pathological changes and putative cytokine mediators. Toxicon 36 (1998) 391-403
67. Touyz R.M. Reactive oxygen species and angiotensin II signaling in vascular cells-implications in cardiovascular disease. Braz. J. Med. Biol. Res. 37 (2004) 1263-1273
68. Uchiyama M., and Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem 86 (1978) 271-278
69. Valdez-Cruz N.A., Segovia L., Corona M., and Possani L.D. Sequence analysis and phylogenetic relationship of genes encoding heterodimeric phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus. Gene 396 (2007) 149-158
70. Vera L.P., Teixeira C.F., Tambourgi D.V., and Gutierrez J.M. Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms. Toxicon 38 (2000) 1253-1266
71. Vera L.P., and Carlos F.P. The dynamics of cytokine and d nitric oxide secretion in mice injected with Tityus serrulatus scorpion venom. Mediators Inflamm 11 3 (2002) 173-180
72. Watt D.D., and Simard J.M. Neurotoxic proteins in scorpion venom. J. Toxicol. Toxin Rev. 3 (1984) 181-221
73. Whetstone P.A., and Hammock B.D. Delivery methods for peptide and protein toxins in insect control. Toxicon 49 (2007) 576-596
74. Zeng X., Gerardo Corzo G., and Hahin R. Scorpion venom peptides without disulfide bridges. IUBMB Life 57 1 (2005) 13-21
75. Zlotkin E., Miranda F., Kopeyan C., and Lissitzky S. A new toxic protein in the venom of the scorpion Androctonus australis Hector. Toxicon 9 (1971) 9-13
76. Zlotkin E., Kadour D., Pelhate M., Martin Eauclaire M., and Rochat H. An excitatory and a depressant insect toxin from scorpion venom both affect sodium conductance and possess a common binding site. Arch. Biochem. Biophys 240 (1985) 877-887
77. Zlotkin E., Eitan M., Bindokas V.P., Adams M.E., Moyer M., Burkhart W., and Fowler E. Functional duality and structural uniqueness of depressant insect-selective neurotoxins. Biochemistry 30 (1991) 4814-4821