Intraspecific variability and pharmacokinetic characteristics of Androctonus mauretanicus mauretanicus scorpion venom

Toxicon

Volumn 40, Issue 11, 2002, Pages 1609-1616

  El Hafny, B ^a   Chgoury, F ^a   Adil, N ^b   Cohen, N ^a   Hassar, M ^a  

^a Institut Pasteur du Maroc   (Morocco)

^b Faculté de Médecine et de Pharmacie   (Morocco)

Author keywords

Androctonus mauretanicus mauretanicus; Pharmacokinetic; Scorpion venom; Venom variability

Indexed keywords

SCORPION VENOM; VENOM ANTISERUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; ENVENOMATION; ENZYME LINKED IMMUNOSORBENT ASSAY; LD 50; LETHALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT;

ANIMALS; ANTIVENINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HORSES; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LETHAL DOSE 50; MICE; MICE, INBRED STRAINS; RABBITS; RECEPTORS, IMMUNOLOGIC; SCORPION VENOMS; SCORPIONS;

ANDROCTONUS; ANDROCTONUS MAURETANICUS MAURETANICUS; ORYCTOLAGUS CUNICULUS; SCORPIONES;

EID: 0036844444     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00178-2     Document Type: Article

References (27)

1. Behrens B., Karber C. Wie sind Rechenversuche fur biologische Auswertungen am Zweexmässigsten Anzuordnen. Arch. Exp. Path. Pharmak. 177:1935;379-388.
2. Bücherl W. Classification, biology, and venom extraction of scorpions. Bücherl W., Buckley E.E., Venomous Animals and their Venoms. 1971;317-347 Academic Press, New York.
3. Calderon-aranda E.S., Rivière G., Choumet V., Possani L.D., Bon C. Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab′)2. Toxicon. 37:1999;771-782.
4. Chavez-Olortegui C., Fonseca S.C.G., Campolina D., Amaral C.F.S., Diniz C.R. ELISA for the detection of toxic antigens in experimental and clinical envenoming by Tityus serrulatus scorpion venom. Toxicon. 32:1994;1649-1656.
5. El Ayeb M., Rochat H. Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis hector. Toxicon. 23:1985;755.
6. Ghalim N., El hafny B., Sebti F., Heikel J., Lazar N., Moustanir R., Benslimane A. Scorpion envenomation and serotherapy in Morocco. Am. J. Med. Hyg. 62:(2):2000;277-283.
7. Gibaldi M., Perrier D. Gibaldi M., Perrier D., Pharmacokinetics. 1982;199-219 Marcel Dekker, New York.
8. Ismail M. The treatment of scorpion envenoming syndrome: the Saudi experience with serotherapy. Toxicon. 32:1994;1019-1026.
9. Ismail M., Abd-Elsalam M.A. Serotherapy of scorpion envenoming: pharamacokinetics of antivenom and a critical assessment of their usefulness. Bon C., Goyffon M., Envonoming and their Treatments. 1996;135-153 Fondation Marcel Mérieux, Paris, France.
10. Ismail M., Abdullah M.E., Morad A., Ageet A.M. Pharmacokinetics of I-125-labelled venom from the scorpion Amdroctonus amoreuxi, AUD and SAV. Toxicon. 18:1980;301-308.
11. Ismail M., Fatani A.J.Y., Dabees T.T. Experimental protocols for scorpion envenomation: a review of common therapeutics and effect of kallikrein-kinin inhibitors. Toxicon. 30:1992;1257-1279.
12. Ismail M.A., Abd-Elsalam M.A., Al-Ahaidib M.S. Androctonus crassicauda (Olivier), a dangerous and unduly neglected scorpion. I. Pharmacological and clinical studies. Toxicon. 32:(12):1994;1599-1618.
13. Kalapothakis E., Chavez-Olortegui C. Venom variability among several Tityus serrulatus specimens. Toxicon. 35:(10):1997;1523-1529.
14. Krifi M.N., Kharrat H., Zghal K., Abouli M., Abroug F., Bouchoucha S., Dellagi K. Development of an ELISA for the detection of scorpion venom in sera of humans envenomed by Androctonus australis garzonii (AAG) and Buthus occitanus tunetanus (BOT): correlation with clinical severity of envenoming in Tunisia. Toxicon. 36:1998;887-900.
15. Laraba-Djebari F., Hammoudi D. Use of toxic fraction isolated from Algerian Androctonus australis hector scorpion venom for the assessment of anti-venom serum. Arch. Inst. Pasteur Alger. 62:1998;254-266.
16. Martin M.F., Rochat H., Marchot P., Bougis P.E. Use of high performance liquid chromatography to demonstrate quantitative variation in components of venom from the scorpion Androctonus australis hector. Toxicon. 25:(5):1987;569-573.
17. Pépin-Covatta S., Lutsch C., Grandgeorge M., Lang J., Scherrmann J.M. Immunoreactivity and pharmacokinetics of horse anti-scorpion venom F(ab′)2-scorpion venom interactions. Toxicol. Appl. Pharmacol. 141:1996;272-277.
18. Revelo M.P., Bambirra E.A., Ferreira A.P., Diniz C.R.O., Chavez-Olortegui C. Body distribution of Tityus serrulatus scorpion venom in mice and effects of scorpion antivenom. Toxicon. 4:1996;1119-1125.
19. de Rezende N.A., Dias M.B., Campolina D., Chavez-Olortegui C., Diniz C.R., Amaral C.F.S. Efficacy of antivenom therapy for neutralizing circulating venom antigens in patients stung by Tityus serrulatus scorpions. Am. J. Trop. Med. Hyg. 52:(3):1995;277-280.
20. de Rezende N.A., Chavez-Olortegui C., Amaral C.F.S. Is the severity of Tityus serrulatus scorpion envenoming related to plasma venom concentrations? Toxicon. 34:(7):1996;820-823.
21. de Rezende N.A., Amaral C.F.S., Fereire-Maia L. Immunotherapy for scorpion envenoming in Brazil. Toxicon. 36:(11):1998;1507-1513.
22. Santana G.C., Freire A.C.T., Ferreira A.P.L., Chaves-Olortegui C., Diniz C.R., Freire-Maia L. Pharmacokinetics of Tityus serrulatus scorpion venom determined by enzyme-linked immunosorbent assay in the rat. Toxicon. 14:(9):1996;1063-1066.
23. Scherrman J.M., Pépin S. Biodynamics of the in vivo antigen-antibody neutralization. Bon C., Goyffon M., Envenoming and their Treatments. 1996;Fondation Marcel Mérieux, Paris, France.
24. Watt D.D., Simard J.M. Neurotoxic proteins in scorpion venom. J. Toxicol. Toxin Rev. 3:1984;181-221.
25. Zerrouk H., Bougis P.E., Céard B., Benslimane A., Martin-Eauclaire M.F. Analysis by high-performance liquid chromatography of Androctonus mauretanicus mauretanicus (Black scorpion) venom. Toxicon. 29:1991;951-960.
26. Zerrouk H., Mansuelle P., Benslimane A., Rochat H., Martin-Eauclaire M.F. Characterization of new leiurotoxin I-like scorpion PO5 from Androctonus mauretanicus mauretanicus. FEBS. 320:1993;189-192.
27. + channel. Int. J. Peptide Protein Res. 48:1996;514-521.