Testis cancer cells have a genetic determination for a high sensitivity to apoptosis inducing stimuli

Urologic Oncology: Seminars and Original Investigations

Volumn 28, Issue 1, 2010, Pages 49-58

  Schmelz, Hans U ^a   Port, Matthias ^b   Stockinger, Markus ^c   Ruf, Christian ^c   Martinscheck, Andreas ^d   Sparwasser, Christoph ^d   Weidner, Wolfgang ^e   Abend, Michael ^c  

^a BUNDESWEHRZENTRALKRANKENHAUS KOBLENZ   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c Institute of Radiobiology   (Germany)

^d BUNDESWEHRKRANKENHAUS ULM   (Germany)

^e JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Apoptosis; Gene expression; Testis cancer

Indexed keywords

CASPASE 3; CASPASE 4; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN E; CYCLIN E1; FAS LIGAND; P21 ACTIVATED KINASE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; PHARMACOGENETICS; PRIORITY JOURNAL; TESTIS CANCER;

ADULT; APOPTOSIS; BIOPSY; GENE EXPRESSION REGULATION; HUMANS; MALE; TESTICULAR NEOPLASMS; YOUNG ADULT;

EID: 72749086843     PISSN: 10781439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.urolonc.2008.11.003     Document Type: Article

References (32)

1. Boyle P. Testicular cancer: The challenge for cancer control. Lancet Oncol 5 (2004) 5661
2. Huyghe E., Matsuda T., and Thonneau P. Increasing incidence of testicular cancer worldwide: A review. J Urol 170 (2003) 5-11
3. Einhorn L.H. Curing metastatic testicular cancer. Proc Natl Acad Sci USA 99 (2002) 4592-4595
4. Mayer F., Stoop H., Scheffer G.L., et al. Molecular determinants of treatment response in human germ cell tumors. Clin Cancer Res 9 (2003) 767-773
5. Spierings D.C., deVries E.G.E., Vellenga E., et al. The attractive Achilles heel of germ cell tumors: An inherent sensitivity to apoptosis inducing stimuli. J Pathol 200 (2003) 137-148
6. Timmer-Bosscha H., de Vries E.G., Meijer C., et al. Differential effects of all-trans-retinoic acid, docosahexaenoic acid, and hexadecylphosphocholine on cisplatin-induced cytotoxicity and apoptosis in a cisplatin-sensitive and resistant human embryonal carcinoma cell line. Cancer Chemother Pharmacol 41 (1998) 469-476
7. Burger H., Nooter K., Boersma A.W., et al. Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bcl-2 family proteins in testicular germ cell tumor cell lines. Int J Cancer 73 (1997) 592-599
8. Burger H., Nooter K., Boersma A.W., et al. Expression of p53, Bcl-2, and Bax in cisplatin-induced apoptosis in testicular germ cell tumour cell lines. Br J Cancer 77 (1998) 1562-1567
9. Debatin K.M. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immuother 53 (2004) 153-159
10. Shan B., and Lee W.H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol 14 (1994) 8166-8173
11. Port M., Schmelz H.U., Stockinger M., et al. Gene expression profiling in seminoma and nonseminoma. J Clin Oncol 23 (2005) 58-69
12. Hofmann K., Tomiuk S., Wolff G., et al. Cloning and characterization of the mammalian brain-specific, Mg2+ dependent neutral sphingomyelinase. Proc Natl Acad Sci USA 97 (2000) 5895-5900
13. Yagita H., Takeda K., Hayakawa Y., et al. TRAIL and its receptors as target for cancer therapy. Cancer Sci 95 (2004) 777-783
14. Schmelz H.U., Abend M., Kraft K., et al. Fas/Fas ligand system and apoptosis induction in testicular carcinoma. Cancer 95 (2002) 73-81
15. Sugihara A., Saiki S., Tsuji M., et al. Expression of Fas and Fas ligand in the testes and testicular germ cell tumors: An immunohistochemical study. Anticancer Res 17 (1997) 3861-3865
16. Shao R.G., Gao C.X., Nieves-Neira W., et al. Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. Oncogene 20 (2001) 1852-1859
17. Spierings D.C., de Vries E.G., Vellenga E., et al. Loss of drug-induced activation of the CD95 apoptotic pathway in a cisplatin-resistant testicular germ cell tumor cell line. Cell Death Differ 10 (2003) 808-822
18. Bennett M., MacDonnald K., Chan S.W., et al. Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis. Science 282 (1998) 290-293
19. Kirkin V., Joos S., and Zörnig M. The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644 (2004) 229-249
20. Oltvai Z.N., Milliman C.L., and Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 (1993) 609-619
21. Chresta C.M., Masters J.R., and Hickman J.A. Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Cancer Res 56 (1996) 1834-1841
22. Heidenreich A., Schenkman N.S., Sesterhenn I.A., et al. Immunohistochemical and mutational analysis of the p53 tumor suppressor gene and the bcl-2 oncogene in primary testicular germ cell tumors. APMIS 106 (1998) 90-99
23. Cory S., and Adams J.M. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2 (2002) 647-656
24. Aggarwal B.B. Nuclear factor-κB: The enemy within. Cancer Cell 6 (2004) 203-208
25. Degen W.G.J., Prujin G.J.M., Raats J.M.H., et al. Caspase-dependent cleavage of nucleic acids. Cell Death Differ 7 (2000) 616-627
26. Thornberry N.A., and Lazebnik Y. Caspases: Enemies within. Science 281 (1998) 1312-1316
27. Hitomi J., Katayama T., Eguchi Y., et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death. Cell 165 (2004) 347-356
28. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
29. Leng X., Connell-Crowley L., Goodrich D., et al. S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr Biol 7 (1997) 709-712
30. Datta M.W., Macri E., Signoretti S., et al. Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of mdm-2 expression. Mod Pathol 14 (2001) 437-442
31. Schmidt B.A., Rose A., Steinhoff C., et al. Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors. Cancer Res 61 (2001) 4214-4221
32. Chaganti R.S., and Houldswoth J. Genetics and biology of adult male germ cell tumors. Cancer Res 60 (2000) 1475-1482