Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population

Calcified Tissue International

Volumn 85, Issue 6, 2009, Pages 501-506

  Mencej Bedrač, Simona ^a   Preželj, Janez ^b   Kocjan, Tomaž ^b   Komadina, Radko ^c   Marc, Janja ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^c General Hospital Celje   (Slovenia)

Author keywords

Catenin; Dickkopf1; Sclerostin; Single nucleotide polymorphism; Wnt signaling pathway

Indexed keywords

BETA CATENIN; DICKKOPF 1 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; SCLEROSTIN; WNT PROTEIN;

ADULT; ARTICLE; BONE DENSITY; BONE MASS; BONE METABOLISM; CONTROLLED STUDY; FEMALE; FEMUR NECK; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCLAST; OSTEOPOROSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SLOVENIA;

AGED; BETA CATENIN; BONE DENSITY; BONE MORPHOGENETIC PROTEINS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LDL-RECEPTOR RELATED PROTEINS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SPINAL FRACTURES;

EID: 72449190049     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-009-9306-y     Document Type: Article

References (34)

1. SH Ralston 2002 Genetic control of susceptibility to osteoporosis J Clin Endocrinol Metab 87 2460 2466 10.1210/jc.87.6.2460 12050200 (Pubitemid 34655301)
2. TP Hill D Später MM Taketo W Birchmeier C Hartmann 2005 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes Dev Cell 8 727 738 10.1016/j.devcel.2005.02.013 15866163 (Pubitemid 40585295)
3. R Baron G Rawadi 2007 Targeting the Wnt/β-catenin pathway to regulate bone formation in the adult skeleton Endocrinology 148 2635 2643 10.1210/en.2007-0270 17395698 (Pubitemid 46984775)
4. DA Glass II P Bialek JD Ahn M Starbuck MS Patel H Clevers MM Taketo F Long AP McMahon RA Lang G Karsenty 2005 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation Dev Cell 8 751 764 10.1016/j.devcel.2005.02.017 15866165 (Pubitemid 40585297)
5. WS Simonet DL Lacey CR Dunstan M Kelley MS Chang R Luthy HQ Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero HL Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg TM Hughes D Hill W Pattison P Campbell S Sander G Van J Tarpley P Derby R Lee WJ Boyle 1997 Osteoprotegrin: a novel secreted protein involved in the regulation of bone density Cell 89 309 319 10.1016/S0092-8674(00)80209-3 9108485
6. SL Holmen CR Zylstra A Mukherjee RE Sigler MC Faugere ML Bouxsein L Deng TL Clemens BO Williams 2005 Essential role of beta-catenin in postnatal bone acquisition J Biol Chem 280 21162 21168 10.1074/jbc.M501900200 15802266 (Pubitemid 40805677)
7. SH Ralston B Crombrugghe 2006 Genetic regulation of bone mass and susceptibility to osteoporosis Genes Dev 20 2492 2506 10.1101/gad.1449506 16980579 (Pubitemid 44396835)
8. RD Little JP Carulli RG Del Mastro J Dupuis M Osborne C Folz SP Manning PM Swain SC Zhao B Eustace MM Lappe L Spitzer S Zweier K Braunschweiger Y Benchekroun X Hu R Adair L Chee MG FitzGerald C Tulig A Caruso N Tzellas A Bawa B Franklin S McGuire X Nogues G Gong KM Allen A Anisowicz AJ Morales PT Lomedico SM Recker P Van Eerdewegh RR Recker ML Johnson 2002 A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait Am J Hum Genet 70 11 19 10.1086/338450 11741193 (Pubitemid 34031693)
9. MA Koay PY Woon Y Zhang LJ Miles EL Duncan SH Ralston JE Compston C Cooper R Keen BL Langdahl A MacLelland J O'Riordan HA Pols DM Reid AG Uitterlinden JA Wass MA Brown 2004 Influence of LRP5 polymorphisms on normal variation in BMD J Bone Miner Res 19 1619 1627 10.1359/JBMR.040704 15355556 (Pubitemid 41094324)
10. SL Ferrari S Deutsch U Choudhury T Chevalley JP Bonjour ET Dermitzakis R Rizzoli SE Antonarakis 2004 Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites Am J Hum Genet 74 866 875 10.1086/420771 15077203 (Pubitemid 38568961)
11. J Bollerslev SG Wilson IM Dick FM Islam T Ueland L Palmer A Devine RL Prince 2005 LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women Bone 36 599 606 10.1016/j.bone.2005.01.006 15777745 (Pubitemid 40602253)
12. JB van Meurs F Rivadeneira M Jhamai W Hugens A Hofman JP van Leeuwen HA Pols AG Uitterlinden 2006 Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men J Bone Miner Res 21 141 150 10.1359/JBMR.050904 16355283 (Pubitemid 43023236)
13. DH Xiong SF Lei F Yang L Wang YM Peng W Wang RR Recker HW Deng 2007 Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites J Bone Miner Res 22 385 393 10.1359/jbmr.061116 17241106 (Pubitemid 46797121)
14. JB van Meurs TA Trikalinos SH Ralston S Balcells ML Brandi K Brixen DP Kiel BL Langdahl P Lips O Ljunggren R Lorenc B Obermayer-Pietsch C Ohlsson U Pettersson DM Reid F Rousseau S Scollen W Van Hul L Agueda K Akesson LI Benevolenskaya SL Ferrari G Hallmans A Hofman LB Husted M Kruk S Kaptoge D Karasik MK Karlsson M Lorentzon L Masi FE McGuigan D Mellström L Mosekilde X Nogues HA Pols J Reeve W Renner F Rivadeneira NM van Schoor K Weber JP Ioannidis AG Uitterlinden GENOMOS Study 2008 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 299 1277 1290 10.1001/jama.299.11.1277 18349089
15. S Giroux L Elfassihi G Cardinal N Laflamme F Rousseau 2007 LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women Bone 40 1299 1307 10.1016/j.bone.2007.01.004 17307038 (Pubitemid 46550986)
16. ZL Zhang YJ Qin JW He QR Huang M Li YQ Hu YJ Liu 2005 Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal women Acta Pharmacol Sin 26 1111 1116 10.1111/j.1745-7254.2005.00173.x 16115379 (Pubitemid 41296951)
17. AG Uitterlinden PP Arp BW Paeper P Charmley S Proll F Rivadeneira Y Fang JB van Meurs TB Britschgi JA Latham RC Schatzman HA Pols ME Brunkow 2004 Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites Am J Hum Genet 75 1032 1045 10.1086/426458 15514891 (Pubitemid 39532072)
18. AM Sims N Shephard K Carter T Doan A Dowling EL Duncan J Eisman G Jones G Nicholson R Prince E Seeman G Thomas JA Wass MA Brown 2008 Genetic analysis in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes J Bone Miner Res 23 499 506 10.1359/jbmr.071113 18021006
19. World Health Organisation 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO Study Group World Health Organ Tech Rep Ser 843 1 129
20. TL Stewart H Jin FEA McGuigan OME Albagha N Garcia-Giralt A Bassiti D Grinberg S Balcells DM Reid SH Ralston 2006 Haplotypes defined by promoter and intron 1 polymorphisms of the COLIA1 gene regulate bone mineral density in women J Clin Endocrinol Metab 91 3575 3583 10.1210/jc.2005-2651 16804049 (Pubitemid 44402140)
21. A Koch D Denkhaus S Albrecht I Leuschner D von Schweinitz T Pietsch 1999 Childhood hepatoblastoma frequently carry a mutated degradation targeting box of the β-catenin gene Cancer Res 59 269 273 9927029
22. E Chan U Gat JM McNiff E Fuchs 1999 A common human skin tumour is caused by activating mutations in β-catenin Nat Genet 21 410 413 10.1038/7747 10192393 (Pubitemid 29159579)
23. G Moreno-Bueno C Gamallo L Perez-Gallego F Contreras J Palacios 2001 Beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles Br J Dermatol 145 576 581 10.1046/j.1365-2133.2001.04455.x 11703283 (Pubitemid 36138918)
24. HapMap Project (2009) http://www.hapmap.org/. Accessed July 2009
25. W Balemans D Foernzler C Parsons M Ebeling A Thompson DM Reid K Lindpaintner SH Ralston W Van Hul 2002 Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five women Bone 31 515 519 10.1016/S8756-3282(02)00844-X 12398949 (Pubitemid 35175456)
26. JB Richards F Rivadeneira M Inouye TM Pastinen N Soranzo SG Wilson T Andrew M Falchi R Gwilliam KR Ahmadi AM Valdes P Arp P Whittaker DJ Verlaan M Jhamai V Kumanduri M Moorhouse JB van Meurs A Hofman HA Pols D Hart G Zhai BS Kato BH Mullin F Zhang P Deloukas AG Uitterlinden TD Spector 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study Lancet 371 1505 1512 10.1016/S0140-6736(08)60599-1 18455228
27. BNH Tran ND Nguyen JA Eisman TV Nguyen 2008 Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis BMC Med Genet 9 55 10.1186/1471-2350-9-55 18588671 (Pubitemid 352025052)
28. Y Ezura T Nakajima T Urano Y Sudo M Kajita H Yoshida T Suzuki T Hosoi S Inoue M Shiraki M Emi 2007 Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 (LRP5) with bone mineral density in adult Japanese women Bone 40 997 1005 10.1016/j.bone.2005.06. 025 17306638 (Pubitemid 46386523)
29. A Saarinen VV Välimäki MJ Välimäki E Löyttyniemi K Auro P Uusen M Kuris AE Lehesjoki O Mäkitie 2007 The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 (LRP5) associates with low peak bone mass in young healthy men Bone 40 1006 1012 10.1016/j.bone.2006.11.010 17223614 (Pubitemid 46386544)
30. K Brixen S Beckers A Peeters E Piters W Balemans TL Nielsen K Wraae L Bathum C Brasen C Hagen M Andersen W Van Hul B Abrahamsen 2007 Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study Calcif Tissue Int 81 421 429 10.1007/s00223-007-9088-z 18058054
31. DP Kiel SL Ferrari LA Cupples D Karasik D Manen A Imamovic AG Herbert J Dupuis 2007 Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men Bone 40 587 596 10.1016/j.bone.2006. 09.029 17137849 (Pubitemid 46187219)
32. E Grundberg EM Lau M Lorentzson M Karlsson A Holmberg L Groop D Mellström E Orwoll H Mallminutes C Ohlsson O Ljunggren K Akesson 2008 Large-scale association studa between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men Osteoporos Int 19 829 837 10.1007/s00198-007-0512-z 18026682
33. JM Koh MH Jung JS Hong HJ Park JS Chang HD Shin SY Kim GS Kim 2004 Association between bone mineral density and LDL receptor-related protein 5 gene polymorphisms in young Korean men J Korean Med Sci 19 407 412 15201508
34. P Lips T Duong A Oleksik D Black S Cummings D Cox T Nickelsen 2001 A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from Multiple Outcomes of Raloxifene Evaluation clinical trial J Clin Endocrinol Metab 86 1212 1221 10.1210/jc.86.3.1212 11238511 (Pubitemid 32323007)