LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women

Bone

Volumn 40, Issue 5, 2007, Pages 1299-1307

  Giroux, Sylvie ^a   Elfassihi, Latifa ^a,b   Cardinal, Guy ^a   Laflamme, Nathalie ^a,b,c   Rousseau, François ^a,b,d  

^a Centre de Recherche du CHUQ HSFA   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c INSTITUT NATIONAL DE SANTÉ PUBLIQUE DU QUÉBEC   (Canada)

^d Centre for the Development   (Canada)

Author keywords

Bone density; Causative variant; LRP5; Peak bone mass; Polymorphisms

Indexed keywords

ALANINE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; METHIONINE; VALINE;

ADULT; AGED; ARTICLE; BONE DENSITY; BONE MASS; CONTROLLED STUDY; ETHNICITY; FEMALE; FEMUR NECK; GENE LINKAGE DISEQUILIBRIUM; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HAPLOTYPE; HUMAN; LUMBAR SPINE; POSTMENOPAUSE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; BONE DENSITY; CANADA; FEMALE; FRANCE; HAPLOTYPES; HORMONES; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MENOPAUSE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 34047262543     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2007.01.004     Document Type: Article

References (30)

1. Newton-John H.F., and Morgan D.B. The loss of bone with age, osteoporosis, and fractures. Clin. Orthop. Relat. Res. 71 (1970) 229-252
2. Pocock N.A., Eisman J.A., Hopper J.L., Yeates M.G., Sambrook P.N., and Eberl S. Genetic determinants of bone mass in adults. A twin study. J. Clin. Invest. 80 3 (1987) 706-710
3. Smith D.M., Nance W.E., Kang K.W., Christian J.C., and Johnston Jr. C.C. Genetic factors in determining bone mass. J. Clin. Invest. 52 11 (1973) 2800-2808
4. Brown L.B., Streeten E.A., Shapiro J.R., McBride D., Shuldiner A.R., Peyser P.A., et al. Genetic and environmental influences on bone mineral density in pre- and post-menopausal women. Osteoporos. Int. 16 12 (2005) 1849-1856
5. Hunter D.J., de Lange M., Andrew T., Snieder H., MacGregor A.J., and Spector T.D. Genetic variation in bone mineral density and calcaneal ultrasound: a study of the influence of menopause using female twins. Osteoporos. Int. 12 5 (2001) 406-411
6. Ralston S.H. Genetic control of susceptibility to osteoporosis. J. Clin. Endocrinol. Metab. 87 6 (2002) 2460-2466
7. Ralston S.H., Uitterlinden A.G., Brandi M.L., Balcells S., Langdahl B.L., Lips P., et al. Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS Study. PLoS Med. 3 4 (2006) e90
8. Cardon L., and Bell J. Association studies designs for complex diseases. Nat. Rev., Genet. 2 (2001) 91-99
9. Newton-Cheh C., and Hirschhorn J.N. Genetic association studies of complex traits: design and analysis issues. Mutat. Res. 573 1-2 (2005) 54-69
10. Tabor H.K., Risch N.J., and Myers R.M. Opinion: candidate-gene approaches for studying complex genetic traits: practical considerations. Nat. Rev., Genet. 3 5 (2002) 391-397
11. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 4 (2001) 513-523
12. Ferrari S.L., Deutsch S., and Antonarakis S.E. Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass. Curr. Opin. Lipidol. 16 2 (2005) 207-214
13. Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N. Engl. J. Med. 346 20 (2002) 1513-1521
14. Little R.D., Carulli J.P., Del Mastro R.G., Dupuis J., Osborne M., Folz C., et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am. J. Hum. Genet. 70 1 (2002) 11-19
15. Van Wesenbeeck L., Cleiren E., Gram J., Beals R.K., Benichou O., Scopelliti D., et al. Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am. J. Hum. Genet. 72 3 (2003) 763-771
16. Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass II D.A., et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J. Cell Biol. 157 2 (2002) 303-314
17. Ferrari S.L., Deutsch S., Choudhury U., Chevalley T., Bonjour J.P., Dermitzakis E.T., et al. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. Am. J. Hum. Genet. 74 5 (2004) 866-875
18. Koay M.A., Woon P.Y., Zhang Y., Miles L.J., Duncan E.L., Ralston S.H., et al. Influence of LRP5 polymorphisms on normal variation in BMD. J. Bone Miner. Res. 19 10 (2004) 1619-1627
19. Koller D.L., Ichikawa S., Johnson M.L., Lai D., Xuei X., Edenberg H.J., et al. Contribution of the LRP5 gene to normal variation in peak BMD in women. J. Bone Miner. Res. 20 1 (2005) 75-80
20. van Meurs J.B., Rivadeneira F., Jhamai M., Hugens W., Hofman A., van Leeuwen J.P., et al. Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men. J. Bone Miner. Res. 21 1 (2006) 141-150
21. Dequeker J., Tobing L., Rutten V., and Geusens P. Relative risk factors for osteoporotic fracture: a pilot study of the MEDOS questionnaire. Clin. Rheumatol. 10 1 (1991) 49-53
22. London S.J., Colditz G.A., Stampfer M.J., Willett W.C., Rosner B., and Speizer F.E. Prospective study of relative weight, height, and risk of breast cancer. JAMA 262 20 (1989) 2853-2858
23. Burkett K.M., Graham J., and McNeney B. hapassoc: software for likelihood inference of trait associations with SNP haplotypes and other attributes. J. Stat. Softw. 16 2 (2006)
24. Jamal S.A., Ridout R., Chase C., Fielding L., Rubin L.A., and Hawker G.A. Bone mineral density testing and osteoporosis education improve lifestyle behaviors in premenopausal women: a prospective study. J. Bone Miner. Res. 14 12 (1999) 2143-2149
25. Rubin L.A., Hawker G.A., Peltekova V.D., Fielding L.J., Ridout R., and Cole D.E. Determinants of peak bone mass: clinical and genetic analyses in a young female Canadian cohort. J. Bone Miner. Res. 14 4 (1999) 633-643
26. Gluer C.C. Quantitative ultrasound techniques for the assessment of osteoporosis: expert agreement on current status. The International Quantitative Ultrasound Consensus Group. J. Bone Miner. Res. 12 8 (1997) 1280-1288
27. Ramensky V., Bork P., and Sunyaev S. Human non-synonymous SNPs: server and survey. Nucleic Acids Res. 30 17 (2002) 3894-3900
28. Gueguen R., Jouanny P., Guillemin F., Kuntz C., Pourel J., and Siest G. Segregation analysis and variance components analysis of bone mineral density in healthy families. J. Bone Miner. Res. 10 12 (1995) 2017-2022
29. Ferrari S., Rizzoli R., Slosman D., and Bonjour J.P. Familial resemblance for bone mineral mass is expressed before puberty. J. Clin. Endocrinol. Metab. 83 2 (1998) 358-361
30. Danielson M.E., Cauley J.A., Baker C.E., Newman A.B., Dorman J.S., Towers J.D., et al. Familial resemblance of bone mineral density (BMD) and calcaneal ultrasound attenuation: the BMD in mothers and daughters study. J. Bone Miner. Res. 14 1 (1999) 102-110