Association between LRP5 polymorphism and bone mineral density: A Bayesian meta-analysis

BMC Medical Genetics

Volumn 9, Issue , 2008, Pages

  Tran, Bich N H ^a   Nguyen, Nguyen D ^a   Eisman, John A ^a,b   Nguyen, Tuan V ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; VALINE; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

AGE; AMINO ACID SUBSTITUTION; ARTICLE; ASIAN; BAYES THEOREM; BONE DENSITY; BONE MASS; CAUCASIAN; ETHNICITY; FEMUR NECK; FRACTURE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INFORMATION PROCESSING; LUMBAR SPINE; MEDICAL LITERATURE; OSTEOPOROSIS; PHENOTYPE; PROBABILITY; SEX DIFFERENCE; ADOLESCENT; ADULT; AGED; BIOLOGICAL MODEL; CONFIDENCE INTERVAL; FEMALE; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; MALE; META ANALYSIS; MIDDLE AGED;

ANIMALIA;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BAYES THEOREM; BONE DENSITY; CONFIDENCE INTERVALS; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MALE; MIDDLE AGED; MODELS, GENETIC; OSTEOPOROSIS; POLYMORPHISM, GENETIC;

EID: 47249133333     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-9-55     Document Type: Article

References (53)

1. Nguyen T Sambrook P Kelly P Jones G Lord S Freund J Eisman J Prediction of osteoporotic fractures by postural instability and bone density BMJ 1993, 307(6912):1111-1115 1679116 8251809
2. Kanis JA Gluer CC An update on the diagnosis and assessment of osteoporosis with densitometry. Committee of Scientific Advisors, International Osteoporosis Foundation Osteoporos Int 2000, 11(3):192-202 10.1007/s001980050281 10824234
3. Marshall D Johnell O Wedel H Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures BMJ 1996, 312(7041):1254-1259 2351094 8634613
4. Eddy DM Johnston CC Cummings SR Dawson-Hughes B Lindsay R Melton LJI Slemenda CW Osteoporosis: Review of the evidence for prevention, diagnosis and treatment and cost-effectiveness analysis Osteoporosis Int 1998, 8:S1-S88 10.1007/s001980050040
5. Browner WS Seeley DG Vogt TM Cummings SR Non-trauma mortality in elderly women with low bone mineral density. Study of Osteoporotic Fractures Research Group Lancet 1991, 338(8763):355-358 10.1016/ 0140-6736(91)90489-C 1677708
6. Kanis JA Melton LJ 3rd Christiansen C Johnston CC Khaltaev N The diagnosis of osteoporosis J Bone Miner Res 1994, 9(8):1137-1141 7976495
7. Nguyen TV Livshits G Center JR Yakovenko K Eisman JA Genetic determination of bone mineral density: Evidence for a major gene J Clin Endocrinol Metab 2003, 88(8):3614-3620 10.1210/jc.2002-030026 12915644
8. Nguyen TV Howard GM Kelly PJ Eisman JA Bone mass, lean mass, and fat mass: Same genes or same environments? Am J Epidemiol 1998, 147(1):3-16 9440393
9. Nguyen TV Eisman JA Pharmacogenomics of osteoporosis: Opportunities and challenges J Musculoskelet Neuronal Interact 2006, 6(1):62-72 16675890
10. Gong Y Vikkula M Boon L Liu J Beighton P Ramesar R Peltonen L Somer H Hirose T Dallapiccola B De Paepe A Swoboda W Zabel B Superti-Furga A Steinmann B Brunner HG Jans A Boles RG Adkins W Boogaard van den MJ Olsen BR Warman ML Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13 Am J Hum Genet 1996, 59(1):146-151 1915094 8659519
11. Johnson ML Gong G Kimberling W Recker SM Kimmel DB Recker RB Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13) Am J Hum Genet 1997, 60(6):1326-1332 1716125 9199553 10.1086/515470
12. Gong Y Slee RB Fukai N Rawadi G Roman-Roman S Reginato AM Wang H Cundy T Glorieux FH Lev D Zacharin M Oexle K Marcelino J Suwairi W Heeger S Sabatakos G Apte S Adkins WN Allgrove J Arslan-Kirchner M Batch JA Beighton P Black GC Boles RG Boon LM Borrone C Brunner HG Carle GF Dallapiccola B De Paepe A Floege B Halfhide ML Hall B Hennekam RC Hirose T Jans A Juppner H Kim CA Keppler-Noreuil K Kohlschuetter A LaCombe D Lambert M Lemyre E Letteboer T Peltonen L Ramesar RS Romanengo M Somer H Steichen-Gersdorf E Steinmann B Sullivan B Superti-Furga A Swoboda W Boogaard van den MJ Van Hul W Vikkula M Votruba M Zabel B Garcia T Baron R Olsen BR Warman ML LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell 2001, 107(4):513-523 10.1016/ S0092-8674(01)00571-2 11719191
13. Little RD Carulli JP Del Mastro RG Dupuis J Osborne M Folz C Manning SP Swain PM Zhao SC Eustace B Lappe MM Spitzer L Zweier S Braunschweiger K Benchekroun Y Hu X Adair R Chee L FitzGerald MG Tulig C Caruso A Tzellas N Bawa A Franklin B McGuire S Nogues X Gong G Allen KM Anisowicz A Morales AJ Lomedico PT Recker SM Van Eerdewegh P Recker RR Johnson ML A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait Am J Hum Genet 2002, 70(1):11-19 419982 11741193 10.1086/338450
14. Boyden LM Mao J Belsky J Mitzner L Farhi A Mitnick MA Wu D Insogna K Lifton RP High bone density due to a mutation in LDL-receptor-related protein 5 N Engl J Med 2002, 346(20):1513-1521 10.1056/NEJMoa013444 12015390
15. Van Wesenbeeck L Cleiren E Gram J Beals RK Benichou O Scopelliti D Key L Renton T Bartels C Gong Y Warman ML De Vernejoul MC Bollerslev J Van Hul W Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density Am J Hum Genet 2003, 72(3):763-771 1180253 12579474 10.1086/368277
16. Bollerslev J Wilson SG Dick IM Islam FM Ueland T Palmer L Devine A Prince RL LRP5 gene polymorphisms predict bone mass and incident fractures in elderly Australian women Bone 2005, 36(4):599-606 10.1016/ j.bone.2005.01.006 15777745
17. Ferrari SL Deutsch S Choudhury U Chevalley T Bonjour JP Dermitzakis ET Rizzoli R Antonarakis SE Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites Am J Hum Genet 2004, 74(5):866-875 1181981 15077203 10.1086/420771
18. Ezura Y Nakajima T Urano T Sudo Y Kajita M Yoshida H Suzuki T Hosoi T Inoue S Shiraki M Emi M Association of a single-nucleotide variation (A1330V) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) with bone mineral density in adult Japanese women Bone 2007, 40(4):997-1005 10.1016/j.bone.2005.06.025 17306638
19. Ferrari SL Deutsch S Baudoin C Cohen-Solal M Ostertag A Antonarakis SE Rizzoli R de Vernejoul MC LRP5 gene polymorphisms and idiopathic osteoporosis in men Bone 2005, 37(6):770-775 10.1016/j.bone.2005.06.017 16168727
20. Giroux S Elfassihi L Cardinal G Laflamme N Rousseau F LRP5 coding polymorphisms influence the variation of peak bone mass in a normal population of French-Canadian women Bone 2007, 40(5):1299-1307 10.1016/ j.bone.2007.01.004 17307038
21. Grundberg E Lau EM Lorentzson M Karlsson M Holmberg A Groop L Mellstrom D Orwoll E Mallmin H Ohlsson C Ljunggren O Akesson K Large-scale association study between two coding LRP5 gene polymorphisms and bone phenotypes and fractures in men Osteoporos Int 2007. 18026682
22. Koay MA Woon PY Zhang Y Miles LJ Duncan EL Ralston SH Compston JE Cooper C Keen R Langdahl BL MacLelland A O'Riordan J Pols HA Reid DM Uitterlinden AG Wass JA Brown MA Influence of LRP5 polymorphisms on normal variation in BMD J Bone Miner Res 2004, 19(10):1619-1627 10.1359/ JBMR.040704 15355556
23. Koh JM Jung MH Hong JS Park HJ Chang JS Shin HD Kim SY Kim GS Association between bone mineral density and LDL receptor-related protein 5 gene polymorphisms in young Korean men J Korean Med Sci 2004, 19(3):407-412 15201508
24. Koller DL Ichikawa S Johnson ML Lai D Xuei X Edenberg HJ Conneally PM Hui SL Johnston CC Peacock M Foroud T Econs MJ Contribution of the LRP5 gene to normal variation in peak BMD in women J Bone Miner Res 2005, 20(1):75-80 15619672
25. DerSimonian R Laird N Meta-analysis in clinical trials Control Clin Trials 1986, 7(3):177-188 10.1016/0197-2456(86)90046-2 3802833
26. Normal ST Meta-analysis: Formulating, evaluating, combining, and reporting Stat Med 1999, 18:321-359 10.1002/ (SICI)1097-0258(19990215)18:3<321::AID-SIM28>3.0.CO;2-P 10070677
27. Spiegelhalter DJ Abrams KR Myles JP Bayesian Approaches to Clinical Trials and Health-Care Evaluation West Sussex, England: John Wiley & Sons Ltd 2004.
28. Sutton AJ Abrams KR Jones DR Sheldon TA Song F Methods for Meta-Analysis in Medical Research West Sussex, England: John Wiley & Sons Ltd 2000.
29. R Development Core Team R: A Language and Environment for Statistical Computing 2.7.0 edn Vienna, Austria: R Foundation for Statistical Computing 2008 http://www.R-project.org
30. van Meurs JB Trikalinos TA Ralston SH Balcells S Brandi ML Brixen K Kiel DP Langdahl BL Lips P Ljunggren O Lorenc R Obermayer-Pietsch B Ohlsson C Pettersson U Reid DM Rousseau F Scollen S Van Hul W Agueda L Akesson K Benevolenskaya LI Ferrari SL Hallmans G Hofman A Husted LB Kruk M Kaptoge S Karasik D Karlsson MK Lorentzon M Masi L McGuigan FE Mellstrom D Mosekilde L Nogues X Pols HA Reeve J Renner W Rivadeneira F van Schoor NM Weber K Ioannidis JP Uitterlinden AG Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 2008, 299(11):1277-1290 10.1001/jama.299.11.1277 18349089
31. Spiegelhalter DJ Thomas A Best NJ Lunn D WinBUGS User Manual Version 1.4 MRC Biostatistics Unit 2003. http://www.mrc-bsu.cam.ac.uk/bugs/winbugs/ manual14.pdf
32. Cochran WG The combination of estimates from different experiments Biometrics 1954, 10:101-129 10.2307/3001666
33. Higgins JP Thompson SG Quantifying heterogeneity in a meta-analysis Stat Med 2002, 21(11):1539-1558 10.1002/sim.1186 12111919
34. Macaskill P Walter SD Irwig L A comparison of methods to detect publication bias in meta-analysis Stat Med 2001, 20(4):641-654 10.1002/ sim.698 11223905
35. Sterne JA Gavaghan D Egger M Publication and related bias in meta-analysis: Power of statistical tests and prevalence in the literature J Clin Epidemiol 2000, 53(11):1119-1129 10.1016/ S0895-4356(00)00242-0 11106885
36. Brixen K Beckers S Peeters A Piters E Balemans W Nielsen TL Wraae K Bathum L Brasen C Hagen C Andersen M Van Hul W Abrahamsen B Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study Calcif Tissue Int 2007, 81(6):421-429 2151961 18058054 10.1007/s00223-007-9088-z
37. Mizuguchi T Furuta I Watanabe Y Tsukamoto K Tomita H Tsujihata M Ohta T Kishino T Matsumoto N Minakami H Niikawa N Yoshiura K LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density J Hum Genet 2004, 49(2):80-86 10.1007/ s10038-003-0111-6 14727154
38. Zhang ZL Qin YJ He JW Huang QR Li M Hu YQ Liu YJ Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women Acta Pharmacol Sin 2005, 26(9):1111-1116 10.1111/j.1745-7254.2005.00173.x 16115379
39. van Meurs JB Rivadeneira F Jhamai M Hugens W Hofman A van Leeuwen JP Pols HA Uitterlinden AG Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men J Bone Miner Res 2006, 21(1):141-150 10.1359/ JBMR.050904 16355283
40. Saarinen A Valimaki VV Valimaki MJ Loyttyniemi E Auro K Uusen P Kuris M Lehesjoki AE Makitie O The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men Bone 2007, 40(4):1006-1012 10.1016/ j.bone.2006.11.010 17223614
41. Xiong DH Lei SF Yang F Wang L Peng YM Wang W Recker RR Deng HW Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites J Bone Miner Res 2007, 22(3):385-393 10.1359/jbmr.061116 17241106
42. Mann V Ralston SH Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture Bone 2003, 32(6):711-717 10.1016/S8756-3282(03)00087-5 12810179
43. Uitterlinden AG Ralston SH Brandi ML Carey AH Grinberg D Langdahl BL Lips P Lorenc R Obermayer-Pietsch B Reeve J Reid DM Amedei A Bassiti A Bustamante M Husted LB Diez-Perez A Dobnig H Dunning AM Enjuanes A Fahrleitner-Pammer A Fang Y Karczmarewicz E Kruk M van Leeuwen JP Mavilia C van Meurs JB Mangion J McGuigan FE Pols HA Renner W Rivadeneira F van Schoor NM Scollen S Sherlock RE Ioannidis JP The association between common vitamin D receptor gene variations and osteoporosis: A participant-level meta-analysis Ann Intern Med 2006, 145(4):255-264 16908916
44. Fang Y Rivadeneira F van Meurs JB Pols HA Ioannidis JP Uitterlinden AG Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: A meta-analysis Bone 2006, 39(4):938-945 10.1016/j.bone.2006.04.016 16769262
45. Richards JB Rivadeneira F Inouye M Pastinen TM Soranzo N Wilson SG Andrew T Falchi M Gwilliam R Ahmadi KR Valdes AM Arp P Whittaker P Verlaan DJ Jhamai M Kumanduri V Moorhouse M van Meurs JB Hofman A Pols HAP Hart D Zhai G Kato BS Mullin BH Zhang F Deloukas P Uitterlinden AG D ST Bone mineral density, osteoporosis, and osteoporotic fractures: A genome-wide association study The Lancet 2008.
46. Nguyen TV Blangero J Eisman JA Genetic epidemiological approaches to the search for osteoporosis genes J Bone Miner Res 2000, 15(3):392-401 10.1359/jbmr.2000.15.3.392 10750553
47. Xiong DH Shen H Zhao LJ Xiao P Yang TL Guo Y Wang W Guo YF Liu YJ Recker RR Deng HW Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction J Bone Miner Res 2006, 21(11):1678-1695 1829486 17002564 10.1359/jbmr.060808
48. Huang QY Recker RR Deng HW Searching for osteoporosis genes in the post-genome era: Progress and challenges Osteoporos Int 2003, 14(9):701-715 10.1007/s00198-003-1445-9 12904838
49. Spiegelhalter DJ Freedman LS Parmar MKB Bayesian approaches to randomized trials J R Stat Soc 1994, 157(3):357-416 10.2307/2983527
50. Diamond GA Kaul S Prior convictions: Bayesian approaches to the analysis and interpretation of clinical megatrials J Am Coll Cardiol 2004, 43(11):1929-1939 10.1016/j.jacc.2004.01.035 15172393
51. Kiel DP Ferrari SL Cupples LA Karasik D Manen D Imamovic A Herbert AG Dupuis J Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men Bone 2007, 40(3):587-596 1845172 17137849 10.1016/j.bone.2006.09.029
52. Albagha OM Tasker PN McGuigan FE Reid DM Ralston SH Linkage disequilibrium between polymorphisms in the human TNFRSF1B gene and their association with bone mass in perimenopausal women Hum Mol Genet 2002, 11(19):2289-2295 10.1093/hmg/11.19.2289 12217957
53. Rubin LA Hawker GA Peltekova VD Fielding LJ Ridout R Cole DE Determinants of peak bone mass: Clinical and genetic analyses in a young female Canadian cohort J Bone Miner Res 1999, 14(4):633-643 10.1359/ jbmr.1999.14.4.633 10234586