Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2

Biochemistry

Volumn 48, Issue 50, 2009, Pages 11902-11911

  Wu, Gang ^a   Tsai, Ah Lim ^a   Kulmacz, Richard J ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE INHIBITORS; CYCLOOXYGENASES; DICLOFENAC; EPR SPECTROSCOPY; FLURBIPROFEN; INITIAL HYPOTHESIS; ISOFORMS; NIMESULIDE; REDUCTANTS; SYNTHASES; TYROSYL RADICALS;

CATALYSIS; ELECTRON RESONANCE; ENZYMES; FATTY ACIDS; OXIDATION; PARAMAGNETIC RESONANCE; QUANTUM THEORY; STABILITY;

ELECTRON SPIN RESONANCE SPECTROSCOPY;

DICLOFENAC; FLURBIPROFEN; INDOMETACIN; MECLOFENAMIC ACID; NIFLUMIC ACID; NIMESULIDE; PROSTAGLANDIN H; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG EFFECT; DRUG HALF LIFE; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DICLOFENAC; ENZYME ACTIVATION; ENZYME STABILITY; FLURBIPROFEN; FREE RADICALS; HUMANS; OXIDATION-REDUCTION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SULFONAMIDES; THERMODYNAMICS; TYROSINE;

EID: 72449190042     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901600f     Document Type: Article

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