Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis

International Journal of Radiation Oncology Biology Physics

Volumn 49, Issue 2, 2001, Pages 415-419

  Ruiter, Gerald A ^a   Verheij, Marcel ^a,b   Zerp, Shuraila F ^a   Van Blitterswijk, Wim J ^a  

^a ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^b Department of Radiotherapy   (Netherlands)

Author keywords

Alkyl lysophospholipids; Lipid metabolism; Radiotherapy; Signal transduction

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; ANTINEOPLASTIC AGENT; EDELFOSINE; MILTEFOSINE; RADIOSENSITIZING AGENT;

APOPTOSIS; CANCER RADIOTHERAPY; CONFERENCE PAPER; DRUG POTENTIATION; IONIZING RADIATION; LIPID METABOLISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPID ETHERS; PHOSPHOLIPIDS; PHOSPHORYLCHOLINE; SIGNAL TRANSDUCTION;

EID: 0035254650     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01476-0     Document Type: Conference Paper

References (57)

1. 4 mouse fibrosarcoma cells in vitro
2. Effects of neoplastic phospholipids on parameters of cell differentiation in U937 cells
3. 3
4. L
5. The induction of apoptosis is a common feature of the cytotoxic action of ether-linked glycerophospholipids in human leukemic cells
6. Alkylphosphocholines induce apoptosis in HL-60 and U-937 leukemic cells
7. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis
8. Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids
9. Changes in cellular lipid synthesis of normal and neoplastic cells during cytolysis induced by alkyl lysophospholipid analogues
10. Removal of breast cancer cells from bone marrow by in vitro purging with ether lipids and cryopreservation
11. Bone marrow purging in acute leukemia with alkyl-lysophospholipids; A new family of anticancer drugs
12. Phase II trial of topically applied miltefosine solution in patients with metastasized breast cancer
13. Hexadecylphosphocholine in the topical treatment of skin metastases in breast cancer patients
14. Miltefosine as a topical treatment for cutaneous metastases in breast carcinoma
15. Topical application of hexadecylphosphocholine in patients with cutaneous lymphomas
16. Trial of oral miltefosine for visceral leishmaniasis
17. Interference of new alkylphospholipid analogues with mitogenic signal transduction
18. Phase I study of perifosine (D21266), a new alkylphosphocholine analogue (Abstr. 798)
19. Membrane damage in leukemic cells induced by ether and ester lipids; An electron microscopic study
20. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion
21. 2+ signaling by antitumor ether lipid analogues
22. Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues
23. Inhibition of phospholipase Cδ by hexadecylphosphorylcholine and lysophospholipids with antitumor activity
24. Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholine
25. Lysophosphatidylcholine attenuates the cytotoxic effects of the antineoplastic phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
26. Alkylphosphocholines inhibit choline uptake and phosphatidylcholine biosynthesis in rat sympathetic neurons and impair axonal extension
27. Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells
28. Apoptosis triggered by 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP:phosphocholine cytidylyltransferase
29. Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis
30. 3 does not correlate with the relative effects of the alkyl-lysophospholipid on the incorporation of fatty acids into cellular phospholipid
31. Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues
32. 1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells
33. Specificity of receptor tyrosine kinase signaling; Transient versus sustained extracellular signal-regulated kinase activation
34. Phosphatidylcholine breakdown and signal transduction
35. Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines
36. 3 and related analogs
37. Alkyl lysophospholipids inhibit phorbol ester-stimulated phospholipase D activity and DNA synthesis in fibroblasts
38. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
39. The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis
40. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
41. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
42. The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells
43. Involvement of c-Jun NH2-terminal kinase activation and c-Jun in the induction of apoptosis by the ether phospholipd 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
44. Mechanisms and consequences of activation of protein kinase B/Akt
45. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-Kinase, and Akt
46. Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation
47. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
48. Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer
49. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma
50. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer
51. Opposite effect of miltefosine on the antineoplastic activity and haematological toxicity of cyclophosphamide
52. Synergistic cytotoxic effects of ether phospholipid analogues and ionizing radiation in human carcinoma cells
53. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis
54. Membrane-derived second messenger regulates X-ray-mediated tumor necrosis factor alpha gene induction