Killing tumour cells by alkylphosphocholines: Evidence for involvement of CD95

European Journal of Cell Biology

Volumn 80, Issue 1, 2001, Pages 1-10

  Matzke, Astrid ^a   Massing, Ulrich ^b   Krug, Harald F ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Alkylphosphocholines; Apoptosis; BCL 2; Caspases; CD95

Indexed keywords

1 O PHOSPHOCHOLINE 2 AMINOOCTADECANE; 1 O PHOSPHOCHOLINE 2 HYDROXYOCTADECANE; 1 O PHOSPHOCHOLINE 2 N ACETYLOCTADECANE; 1 O PHOSPHOCHOLINE 2 O ACETYLOCTADECANE; ACETAMIDE DERIVATIVE; AMIDE; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; CERAMIDE DERIVATIVE; DNA FRAGMENT; EDELFOSINE; ESTER DERIVATIVE; ETHIDIUM BROMIDE; FAS ANTIGEN; FAS LIGAND; FUNCTIONAL GROUP; GLYCEROL DERIVATIVE; HYDROXYL GROUP; LYSOPHOSPHATIDYLCHOLINE; MILTEFOSINE; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; PHOSPHOLIPID DERIVATIVE; PHOSPHORYLCHOLINE; PROTEIN BCL 2; SODIUM CHLORIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL ACTIVITY; CHEMOTHERAPY; CONTROLLED STUDY; DNA FLANKING REGION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKEMIA CELL LINE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; TUMOR CELL;

EID: 0035137620     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00130     Document Type: Article

References (51)

1. The Bcl-2 protein family: Arbiters of cell survival
2. Selective destruction of human leukemic cells by alkyl-lysophospholipids
3. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors
4. Membrane-interactive lipids as experimental anticancer drugs
5. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
6. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
7. Caspases: The executioners of apoptosis
8. Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols
9. Multiple pathways for apoptotic nuclear fragmentation
10. Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycerophosphocholine: A possible basis for its selective action
11. Signal transduction pathways that regulate cell survival and cell death
12. L
13. Inhibition of human caspases by peptide-based and macromolecular inhibitors
14. The phospholipid analogue, hexadecylphosphocholin, inhibits protein kinase C in vitro and antagonises phorbol esterstimulated cell proliferation
15. 3 acts as an activator of protein kinase C in HL-60 cells
16. 2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid
17. ICE family protease: Mediators of all cell death?
18. Cytotoxic ether phospholipids. Different affinities to lysophosphocholine acyltransferases in sensitive and resistant cells
19. A rapid and simple method for the isolation of apoptotic DNA fragments
20. 2-Hydroxy-and 2-O-acetyl-octadecylphosphocholines: Cytotoxic efficacy and influence of cellular phospholipid metabolism
21. Alkylphosphocholines: A new class of membrane-active anticancer agents
22. Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells
23. Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells
24. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note
25. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
26. Morphological changes of adherent and nonadherent cells by treatment with hexadecylphosphocholine and 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phospho choline observed by scanning electron microscopy
27. Chemopurging of peripheral blood-derived progenitor cells by alkyl-lysophospholipid and its effects on haematopoietic rescue after high-dose therapy
28. Purification and characterization of an interleukin-1β-converting enzyme family protease that activates cysteine protease P32 (CPP32)
29. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
30. Synthesis of enantiomerically pure 1-O-phosphocholine-2-O-acyl-octadecane and 1-O-phosphocholine-2-N-acyl-octadecane
31. Apoptosis in tumorigenesis and cancer therapy
32. Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids
33. L
34. Alkyl phosphocholines: Toxicity and anticancer properties
35. The Fas death factor
36. Effects of antineoplastic ether lipids on model and biological membranes
37. Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily
38. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
39. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
40. Two CD95 (APO-1/Fas) signaling pathways
41. Apoptosis induced by topoisomerase I and II inhibitors in human leukemic HL-60 cells
42. Modulation of cellular apoptotic potential: Contributions to oncogenesis
43. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
44. Caspases: Anemies within
45. Hexadecylphosphocholine, a new ether lipid analogue. Studies on the antineoplastic activity in vitro and in vivo
46. Hexadecylphosphocholine (D18506) in the topical treatment of skin metastases: A phase-I trial
47. Selective killing of malignant cells from leukemia patients by alkyl-lysophospholipid
48. Autologous bone marrow transplantation with alkyl-lysophospholipid-purged marrow
49. Experimental studies on the role of alkyl lysophospholipids in autologous bone-marrow transplantation
50. Glucocorticoid-induced thymocyte apoptosis is associated with endonuclease activation