Biphasic Glucocorticoid-dependent regulation of Wnt expression and its inhibitors in mature osteoblastic cells

Calcified Tissue International

Volumn 85, Issue 6, 2009, Pages 538-545

  Mak, Wendy ^a   Shao, Xinyu ^a,b,c   Dunstan, Colin R ^a   Seibel, Markus J ^a   Zhou, Hong ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Col2.3 GFP mice; Glucocorticoid; Hydroxysteroid dehydrogenase; Osteoblast; Wnt; Wnt inhibitor

Indexed keywords

CORTICOSTERONE; DICKKOPF 1 PROTEIN; GLUCOCORTICOID; PROTEIN WNT2B; SECRETED FRIZZLED RELATED PROTEIN 1; UNCLASSIFIED DRUG; WNT PROTEIN; WNT10B PROTEIN; WNT11 PROTEIN; WNT2 PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN; WNT7B PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALVARIA; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; CELLS, CULTURED; GLUCOCORTICOIDS; MICE; MICE, TRANSGENIC; OSTEOBLASTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION; WNT PROTEINS;

EID: 72449131349     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-009-9303-1     Document Type: Article

References (32)

1. LM Boyden J Mao J Belsky L Mitzner A Farhi MA Mitnick D Wu K Insogna RP Lifton 2002 High bone density due to a mutation in LDL-receptor-related protein 5 N Engl J Med 346 1513 1521 10.1056/NEJMoa013444 12015390 (Pubitemid 34755690)
2. M Kato MS Patel R Levasseur I Lobov BH Chang DA Glass II C Hartmann L Li TH Hwang CF Brayton RA Lang G Karsenty L Chan 2002 Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor J Cell Biol 157 303 314 10.1083/jcb.200201089 11956231 (Pubitemid 34839826)
3. X Li P Liu W Liu P Maye J Zhang Y Zhang M Hurley C Guo A Boskey L Sun SE Harris DW Rowe HZ Ke D Wu 2005 Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation Nat Genet 37 945 952 10.1038/ng1614 16056226 (Pubitemid 43086150)
4. X Li Y Zhang H Kang W Liu P Liu J Zhang SE Harris D Wu 2005 Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling J Biol Chem 280 19883 19887 10.1074/jbc.M413274200 15778503 (Pubitemid 41379516)
5. CN Bennett SE Ross KA Longo L Bajnok N Hemati KW Johnson SD Harrison OA MacDougald 2002 Regulation of Wnt signaling during adipogenesis J Biol Chem 277 30998 31004 10.1074/jbc.M204527200 12055200 (Pubitemid 34970803)
6. W Si Q Kang HH Luu JK Park Q Luo WX Song W Jiang X Luo X Li H Yin AG Montag RC Haydon TC He 2006 CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells Mol Cell Biol 26 2955 2964 10.1128/MCB.26.8.2955-2964. 2006 16581771
7. TF Day X Guo L Garrett-Beal Y Yang 2005 Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis Dev Cell 8 739 750 10.1016/j.devcel.2005.03.016 15866164 (Pubitemid 40585296)
8. TP Hill D Spater MM Taketo W Birchmeier C Hartmann 2005 Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes Dev Cell 8 727 738 10.1016/j.devcel.2005.02.013 15866163 (Pubitemid 40585295)
9. H Zhou W Mak R Kalak J Street C Fong-Yee Y Zheng CR Dunstan MJ Seibel 2009 Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice Development 136 427 436 10.1242/dev.027706 19141672
10. CN Bennett KA Longo WS Wright LJ Suva TF Lane KD Hankenson OA Macdougald 2005 Regulation of osteoblastogenesis and bone mass by Wnt10b Proc Natl Acad Sci USA 102 3324 3329 10.1073/pnas.0408742102 15728361 (Pubitemid 40328044)
11. H Hu MJ Hilton X Tu K Yu DM Ornitz F Long 2005 Sequential roles of Hedgehog and Wnt signaling in osteoblast development Development 132 49 60 10.1242/dev.01564 15576404 (Pubitemid 40207966)
12. H Zhou W Mak Y Zheng CR Dunstan MJ Seibel 2008 Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling J Biol Chem 283 1936 1945 10.1074/jbc.M702687200 18045882
13. PM Stewart ZS Krozowski 1999 11β-Hydroxysteroid dehydrogenase Vitam Horm 57 249 324 10.1016/S0083-6729(08)60646-9 10232052
14. H Woitge J Harrison A Ivkosic Z Krozowski B Kream 2001 Cloning and in vitro characterization of alpha 1(I)-collagen 11beta-hydroxysteroid dehydrogenase type 2 transgenes as models for osteoblast-selective inactivation of natural glucocorticoids Endocrinology 142 1341 1348 10.1210/en.142.3.1341 11181553 (Pubitemid 32202847)
15. LB Sher HW Woitge DJ Adams GA Gronowicz Z Krozowski JR Harrison BE Kream 2004 Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone Endocrinology 145 922 929 10.1210/en.2003-0655 14617568 (Pubitemid 38183836)
16. I Kalajzic Z Kalajzic M Kaliterna G Gronowicz SH Clark AC Lichtler D Rowe 2002 Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage J Bone Miner Res 17 15 25 10.1359/jbmr.2002.17.1.15 11771662
17. Z Kalajzic P Liu I Kalajzic Z Du A Braut M Mina E Canalis DW Rowe 2002 Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters Bone 31 654 660 10.1016/S8756-3282(02)00912-2 12531558 (Pubitemid 36092087)
18. YC Shi L Worton L Esteban P Baldock C Fong JA Eisman EM Gardiner 2007 Effects of continuous activation of vitamin D and Wnt response pathways on osteoblastic proliferation and differentiation Bone 41 87 96 10.1016/j.bone.2007.04.174 17513186 (Pubitemid 46901055)
19. M Zhao M Qiao BO Oyajobi GR Mundy D Chen 2003 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation J Biol Chem 278 27939 27944 10.1074/jbc.M304132200 12738770 (Pubitemid 36899988)
20. CY Logan R Nusse 2004 The Wnt signaling pathway in development and disease Annu Rev Cell Dev Biol 20 781 810 10.1146/annurev.cellbio.20.010403. 113126 15473860 (Pubitemid 39488658)
21. M Almeida L Han T Bellido SC Manolagas S Kousteni 2005 Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT J Biol Chem 280 41342 41351 10.1074/jbc.M502168200 16251184 (Pubitemid 41832191)
22. M Lako S Lindsay J Lincoln PM Cairns L Armstrong N Hole 2001 Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing haematopoietic differentiation Mech Dev 103 49 59 10.1016/S0925-4773(01)00331-8 11335111 (Pubitemid 32457906)
23. H Wang JB Gilner VL Bautch DZ Wang BJ Wainwright SL Kirby C Patterson 2007 Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies J Biol Chem 282 782 791 10.1074/jbc.M606610200 17098737 (Pubitemid 47076672)
24. Y Engelbrecht H de Wet K Horsch CR Langeveldt FS Hough PA Hulley 2003 Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines Endocrinology 144 412 422 10.1210/en.2002-220769 12538600 (Pubitemid 36205211)
25. DJ Rickard TA Sullivan BJ Shenker PS Leboy I Kazhdan 1994 Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2 Dev Biol 161 218 228 10.1006/dbio.1994.1022 8293874 (Pubitemid 24049169)
26. A Scutt P Bertram 1999 Basic fibroblast growth factor in the presence of dexamethasone stimulates colony formation, expansion, and osteoblastic differentiation by rat bone marrow stromal cells Calcif Tissue Int 64 69 77 10.1007/s002239900581 9868287 (Pubitemid 29024632)
27. E Smith B Frenkel 2005 Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner J Biol Chem 280 2388 2394 10.1074/jbc.M406294200 15537647
28. S Walsh GR Jordan C Jefferiss K Stewart JN Beresford 2001 High concentrations of dexamethasone suppress the proliferation but not the differentiation or further maturation of human osteoblast precursors in vitro: relevance to glucocorticoid-induced osteoporosis Rheumatology (Oxford) 40 74 83 10.1093/rheumatology/40.1.74
29. R Kalak H Zhou J Street R Day J Modzelewski P Liu G Li C Dunstan MJ Seibel 2009 Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice Bone 45 61 67 10.1016/j.bone.2009.03.673 19358901
30. LB Sher JR Harrison DJ Adams BE Kream 2006 Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling Calcif Tissue Int 79 118 125 10.1007/s00223-005-0297-z 16927049 (Pubitemid 44306169)
31. Y Ishida JN Heersche 1998 Glucocorticoid-induced osteoporosis: both in vivo and in vitro concentrations of glucocorticoids higher than physiological levels attenuate osteoblast differentiation J Bone Miner Res 13 1822 1826 10.1359/jbmr.1998.13.12.1822 9844099
32. CA O'Brien D Jia LI Plotkin T Bellido CC Powers SA Stewart SC Manolagas RS Weinstein 2004 Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength Endocrinology 145 1835 1841 10.1210/en.2003-0990 14691012 (Pubitemid 38402392)