Comparative pharmacokinetics of intramuscular artesunate and artemether in patients with severe falciparum malaria

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 11, 2004, Pages 4234-4239

  Hien, T T ^a   Davis, T M E ^b   Chuong, L V ^a   Ilett, K F ^b   Sinh, D X T ^a   Phu, N H ^a   Agus, C ^b   Chiswell, G M ^c   White, N J ^a,d   Farrar, J ^a,d,e  

^a Centre for Tropical Diseases Vietnam   (Viet Nam)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c Western Australian Centre for Pathology and Medical Research   (Australia)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e The Hospital for Tropical Diseases   (Viet Nam)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; ARTESUNATE; DIHYDROARTEMISININ; DRUG METABOLITE;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG SOLUBILITY; FEMALE; HUMAN; INJECTION; MALARIA FALCIPARUM; MALE; MINIMUM INHIBITORY CONCENTRATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SIDE EFFECT;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HALF-LIFE; HUMANS; INJECTIONS, INTRAMUSCULAR; MALARIA, FALCIPARUM; MIDDLE AGED; SESQUITERPENES; VIETNAM;

EID: 7244232725     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.11.4234-4239.2004     Document Type: Article

References (25)

1. Artemether-Quinine Meta-Analysis Study Group. 2001. A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 95:637-650.
2. Batty, K. T., T. M. E. Davis, L. T. Thu, T. Q. Binh, T. K. Anh, and K. F. Ilett. 1996. Selective high-performance liquid Chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria. J. Chromatogr. B 677:345-350.
3. Brockman, A., R. N. Price, M. van Vugt, D. G. Heppner, D. Walsh, P. Sookto, T. Wimonwattrawatee, S. Looareesuwan, N. J. White, and F. Nosten. 2000. Plasmodium falciparum antimalarial drug susceptibility on the northwestern border of Thailand during five years of extensive ARTS-mefloquine use. Trans. R. Soc. Trop. Med. Hyg. 94:537-544.
4. Davis, T. M., H. L. Phuong, K. F. Ilett, N. C. Hung, K. T. Batty V. D. Phuong, S. M. Powell, H. V. Thien, and T. Q. Binh. 2001. Pharmacokinetics and pharmacodynamics of intravenous artesunate in severe falciparum malaria. Antimicrob. Agents Chemother. 45:181-186.
5. Grace, J. M., A. J. Aguilar, K. M. Trotman, J. O. Peggins, and T. G. Brewer. 1998. Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450. Drug Metab. Disp. 26:313-317.
6. Hien, T. T., N. P. J. Day, N. H. Phu, N. T. H. Mai, T. T. H. Chau, P. P. Loc, D. X. Sinn, L. V. Chuong, H. Vinh, D. Waller, T. E. A. Peto, and N. J. White. 1996. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. N. Engl. J. Med. 335:76-83.
7. Hien, T. T., N. H. Phu, N. T. H. Mai, T. T. H. Chau, T. T. M. Trang, P. P. Loc, B. M. Cuong, N. T. Dung, H. Vinh, D. J. Waller, and N. J. White. 1992. An open randomized comparison of intravenous and intramuscular artesunate in severe falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 86:584-585.
8. Ilett, K. F., K. T. Batty, S. M. Powell, T. Q. Binh, L. Thi, A. Thu, H. L. Phuong, N. C. Hung, and T. M. E. Davis. 2002. The pharmacokinetic properties of intramuscular artesunate and rectal dihydroartemisinin in uncomplicated falciparum malaria. Br. J. Clin. Pharmacol. 53:23-30.
9. Karbwang, J., K. Na-Bangchang, K. Congpuong, P. Molunto, and A. Thanavibul. 1997. Pharmacokinetics and bioavailability of oral and intramuscular artemether. Eur. J. Clin. Pharmacol. 52:307-310.
10. Karbwang, J., K. Na-Bangchang, T. Tin, K. Sukonstason, W. Rimchala, and T. Harinasuta. 1998. Pharmacokinetics of intramuscular ARM in patients with severe falciparum malaria with or without acute renal failure. Br. J. Clin. Pharmacol. 45:597-600.
11. Looareesuwan, S., P. Wilairatana, P. de Boer, A. Pouwels, S. Krudsood, J. J. van Lier, W. Chokejundachai, F. W. M. Smeets, K. Chalermrut, S. Vannaphan, B. Oosterhuis, and C. B. Lugt. 1999. A comparative study of intramuscular artemitol and artemether in the treatment of severe malaria in children, p. 56. Proceedings of the Joint International Tropical Medicine Meeting, Bangkok, Thailand.
12. Mohamed, S. S., S. A. Khalid, S. A. Ward, T. S. Wan, H. P. Tang, M. Zheng, R. K. Haynes, and G. Edwards. 1999. Simultaneous determination of artemether and its major metabolite dihydroartemisinin in plasma by gas chromatography-mass spectrometry-selected ion monitoring. J. Chromatogr. B Biomed. Appl. 731:251-260.
13. Mordi, M. N., S. M. Mansor, V. Navaratnam, and W. H. Wernsdorfer. 1997. Single dose pharmacokinetics of oral artemether in healthy Malaysian volunteers. Br. J. Clin. Pharmacol. 43:363-365.
14. Murphy, S., E. Mberu, D. Muhia, M. English, J. Crawley, C. Waruiru, B. Lowe, C. Newton, P. Winstanley, K. Marsh, and W. Watkins. 1997. The disposition of intramuscular artemether in children with cerebral malaria: a preliminary study. Trans. R. Soc. Trop. Med. Hyg. 91:331-334.
15. Navaratnam, V., S. M. Mansor, N. W. Sit, J. Grace, Q. Li, and P. Olliaro. 2000. Pharmacokinetics of artemisinin-type compounds. Clin. Pharmacokinet. 39:255-270.
16. Newton, P., Y. Suputtamongkol., P. Teja-Isavadharm, S. Pukrittayakamee. V. Navaratnam, I. Bates, and N. J. White. 2000. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria. Antimicrob. Agents Chemother. 44:972-977.
17. Pukrittayakamee, S., S. Looareesuwan, K. Keeratithakul, T. M. E. Davis, P. Teja-Isavadharm, B. Nagachinta, A. Weber, A. L. Smith, D. Kyle, and N. J. White. 1997. A study of the factors affecting the metabolic clearance of quinine in malaria. Eur. J. Clin. Pharmacol. 52:487-493.
18. Suputtamongkol, Y., P. Newton, B. Angus, P. Teja-Isavadharm, D. Keeratithakul, M. Rasameesoraj, S. Pukrittayakamee, and N. J. White. 2001. A comparison of oral artesunate and artemether antimalarial bioactivities in acute falciparum malaria. Br. J. Clin. Pharmacol. 52:655-661.
19. Teja-Isavadharm, P., F. Nosten, D. E. Kyle, C. Luxemburger, F. ter Kuile, J. O. Peggins, T. G. Brewer, and N. J. White. 1996. Comparative bioavailability of oral, rectal and intramuscular artemether in healthy subjects-use of simultaneous measurement by high performance liquid chromatography with electro-chemical detection and bioassay. Br. J. Clin. Pharmacol. 42:599-604.
20. ter Kuile, F., N. J. White, P. Holloway, G. Pasvol, and S. Krishna. 1993. Plasmodium falciparum: in-vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria. Exp. Parasitol. 76:86-95.
21. van Hensbroek, M. B., E. Omyiorah, and S. Jaffar et al. 1996. A trial of artemether or quinine in children with cerebral malaria. N. Engl. J. Med. 335:69-75.
22. Warrell, D. A., M. Molyneux, and P. Beales. 1990. Severe and complicated malaria. Trans. R. Soc. Trop. Med. Hyg. 84(Suppl. 2):1-69.
23. White, N. J. 1996. The treatment of malaria. N. Engl. J. Med. 335:800-806.
24. White, N. J. 1998. Not much progress in treatment of cerebral malaria. Lancet 352:594-595.
25. White, N. J., S. Looareesuwan, D. A. Warrell, M. J. Warrell, D. Bunnag, and T. Harinasuta. 1982. Quinine pharmacokinetics and toxicity in cerebral and uncomplicated falciparum malaria. Am. J. Med. 73:564-572.