Comparative bioavailability of oral, rectal, and intramuscular artemether in healthy subjects: Use of simultaneous measurement by high performance liquid chromatography and bioassay

British Journal of Clinical Pharmacology

Volumn 42, Issue 5, 1996, Pages 599-604

  Teja Isavadharm, P ^a,c   Nosten, F ^a   Kyle, D E ^b   Luxemburger, C ^c   Ter Kuile, F ^a   Peggins, J O ^e   Brewer, T G ^d   White, N J ^c  

^a ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^b SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

artemether dihydroartemisinin; bioavailability; m alaria; pharmacodynamics; pharmacokinetics

Indexed keywords

ARTEMETHER; DRUG METABOLITE;

ADULT; ANTIMALARIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION;

EID: 0029852334     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1996.tb00115.x     Document Type: Article

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