Pharmacokinetics of intramuscular artemether in patients with severe falciparum malaria with or without acute renal failure

British Journal of Clinical Pharmacology

Volumn 45, Issue 6, 1998, Pages 597-600

  Karbwang, J ^a,c   Na Bangchang, K ^a   Tin, T ^a   Sukontason, K ^a   Rimchala, W ^b   Harinasuta, T ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b Prapok klao Hospital   (Thailand)

^c Clinical Pharmacology Unit   (Thailand)

Author keywords

Acute renal failure; Artemether; Dihydroartemisinin; Pharmacokinetics; Severe malaria

Indexed keywords

ARTEMETHER; DIHYDROARTEMISININ;

ACUTE KIDNEY FAILURE; ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; DRUG ABSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MALARIA FALCIPARUM; MALE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; HUMANS; KIDNEY; KIDNEY FAILURE, ACUTE; MALARIA, FALCIPARUM; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; SESQUITERPENES; TREATMENT OUTCOME;

EID: 0031812372     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1998.00723.x     Document Type: Article

References (16)

1. Wernsdorfer WH. Epidemiology of drug resistance in malaria. Acta Tropica 1994; 56: 143-156.
2. Bunnag D, Karbwang J, Harinasuta T. Artemether in the treatment of multiple drug resistant falciparum malaria. Southeast Asian J Trop Med Public Health 1992; 23: 762-767.
3. Karbwang J, Na-Bangchang K, Thanavibul A, Bunnag D, Chongsupphajaisiddhi T, Harinasuta T. Comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria. Lancet 1992; 340; 1245-1248.
4. Karbwang J, Sukontason K, Rimchala W, et al. Preliminary report: a comparative clinical trial of artemether and quinine in severe falciparum malaria. Southeast Asian J Trop Med Public Health 1992; 23: 768-772.
5. Karbwang J, Na-Bangchang K, Wattanakoon Y, Thanavibul A, Harinasuta T. Artemether 5 versus 7 day regimen for severe falciparum malaria. Southeast Asian J Trop Med Public Health 1994; 25: 702-706.
6. Karbwang J, Tin T, Rimchala W, et al. Comparison of artemether and quinine in the treatment of severe falciparum malaria in south-east Thailand. Trans R Soc Trop Med Hyg 1995; 89: 668-671.
7. Taylor TE, Wills BA, Kazembe P, et al. Rapid comma resolution with artemether in Malawian children with cerebral malaria. Lancet 1992; 93: 661-662.
8. Hensbroek MBV, Onyiorah E, Jaffar S, et al. A trial of artemether or quinine in children with cerebral malaria. New Engl J Med 1996; 335: 69-75.
9. Myint PT, Shwe T. A controlled clinical trial of artemether (qinghaosu derivative) versus quinine in complicated and severe falciparum malaria. Trans R Soc Trop Med Hyg 1987; 81: 559-561.
10. Myint PT, Shwe T, Lin S. Clinical study of the treatment of cerebral malaria with artemether (qinghaosu derivative). Trans R Soc Trop Med Hyg 1989; 83: 72.
11. Hein TT, Day NPJ, Phu NN, et al. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. New Engl J Med 1996; 335: 76-83.
12. China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials. Clinical studies on the treatment of malaria with qinghaosu and its derivatives. J Trad Chin Med 1982; 2: 17-24.
13. World Health Organization. Severe and complicated malaria, 2nd edn. Trans R Soc Trop Med Hyg 1990; 84(suppl 2).
14. Karbwang J, Na-Bangchang K, Molunto P, Banmairuroi V, Congpuoug K. Determination of artemether and its major metabolite, dihydroartemisinin in plasma using high performance liquid chromatography with electrochemical detection. J Chromatogr 1997; 690: 259-265.
15. Gibaldi M. Biopharmaceutics and clinical pharmacokinetics, 4th edn. Lea and Febiger, U.K., 1991, pp 14-23.
16. Karbwang J, Na-Bangchang K, Congpuong K, Molunto P, Thanavibul A. Pharmacokinetics and bioavailability of oral and intramuscular artemether. Eur J Clin Pharmacol 1997; 52: 307-310.