A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 95, Issue 6, 2001, Pages 637-650

  Stepniewska, Kasia ^a   Day, Nicholas ^a   Babiker, Abdel ^a   Laloo, David ^a   Warrell, David ^a   Olliaro, Piero ^a   White, Nicholas ^a   Garner, Paul ^a   Peto, Tim ^a   Winstanley, Peter ^a   van Hensbroek, Michael Boele ^a   Danis, Martin ^a   Davies, Cathy ^a   Hien, Tran Tinh ^a   Karbwang, Juntra ^a   Kwiatkowski, Dominic ^a   Marsh, Kevin ^a   McIntosh, Heather ^a   Molyneux, Malcolm ^a   Murphy, Steven ^a   Seaton, Andrew ^a   Taylor, Terrie ^a   Watkins, Bill ^a   more..

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Artemether; Chemotherapy; Individual patient data; Malaria; Meta analysis; Neurotoxicity; Plasmodium falciparum; Quinine; Sequelae; Severe disease

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; ARTESUNATE; CINCHONA ALKALOID; QUININE;

ADULT; ARTICLE; CHILD; CLINICAL TRIAL; COMA; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; FEMALE; FEVER; HUMAN; MALARIA FALCIPARUM; MALE; META ANALYSIS; MORTALITY; NEUROLOGICAL COMPLICATION; NEUROTOXICITY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS;

CINCHONA; CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 18244386513     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(01)90104-X     Document Type: Article

References (29)

1. Neurotoxicity in animals due to arteether and artemether
2. Seasonal variation of paediatric diseases in The Gambia, west Africa
3. Results obtained with i.m. artemether versus i.v. quinine in the treatment of severe malaria in a multi-centre study in Africa
4. Cerebral malaria. Factors affecting outcome of treatment in a suboptimal clinical setting
5. Dose-dependent brainstem neuropathology following repeated arteether administration in rats
6. Behavioral and neural toxicity of arteether in rats
7. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria
8. The Statistical Analysis of Failure Time Data
9. Comparison of artemether and quinine in the treatment of severe falciparum malaria in south-east Thailand
10. Artemisinin derivatives in the treatment of severe malaria
11. An open randomized trial of artemether versus quinine in the treatment of cerebral malaria in African children
12. The disposition of intramuscular artemether in children with cerebral malaria: A preliminary study
13. A controlled trial of artemether (qinghaosu derivative) versus quinine in complicated and severe falciparum malaria
14. Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice
15. Arteether: Risks of two-week administration in Macaca mulatta
16. Artemether for severe malaria: A meta-analysis of randomized clinical trials
17. Antimalarial studies on qinghaosu
18. African children with malaria in an area of intense Plasmodium falciparum transmission: Features on admission to the hospital and risk factors for death
19. Randomized comparison of intramuscular artemether and intravenous quinine in adult, Melanesian patients with severe or complicated Plasmodium falciparum malaria in Papua New Guinea
20. The effect of mefloquine-artemether compared with quinine on patients with complicated falciparum malaria
21. Severe childhood malaria in two areas of markedly different falciparum transmission in east Africa
22. Meta-analysis of the literature or of individual patient data: Is there a difference?
23. Intramuscular artemether vs intravenous quinine: An open, randomized trial in Malawian children with cerebral malaria
24. A trial of artemether or quinine in children with cerebral malaria
25. An open randomized comparative study of intramuscular artemether and intravenous quinine in cerebral malaria in children
26. Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus oral tetracycline for treating cerebral malaria