Dividing roles of prion protein in staurosporine-mediated apoptosis

Biochemical and Biophysical Research Communications

Volumn 349, Issue 2, 2006, Pages 759-768

  Zhang, Ying ^a,b   Qin, Kefeng ^c   Wang, Jianwei ^b   Hung, Tao ^a,b   Zhao, Richard Y ^c  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bax; Caspase 3; Cell cycle; DNA fragmentation; Prion protein; Staurosporine

Indexed keywords

CASPASE 3; DNA FRAGMENT; GLYCOPROTEIN; PRION PROTEIN; PROTEIN BAX; STAUROSPORINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; CELL CYCLE; CELL CYCLE G2 PHASE; CELL STRAIN HEK293; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; CYTOTOXICITY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA FRAGMENTATION; DOWN-REGULATION; ENZYME INHIBITORS; GLYCOPROTEINS; HUMANS; PRIONS; RNA, SMALL INTERFERING; STAUROSPORINE;

EID: 33748417398     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.116     Document Type: Article

References (27)

1. Westaway D., and Carlson G.A. Mammalian prion proteins: enigma, variation and vaccination. Trends Biochem. Sci. 27 (2002) 301-307
2. Bueler H., Fischer M., Lang Y., Bluethmann H., Lipp H.P., DeArmond S.J., Prusiner S.B., Aguet M., and Weissmann C. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356 (1992) 577-582
3. Qin K., O'Donnell M., and Zhao R.Y. Doppel: more rival than double to prion. Neuroscience 141 (2006) 1-8
4. Roucou X., and LeBlanc A.C. Cellular prion protein neuroprotective function: implications in prion diseases. J. Mol. Med. 83 (2005) 3-11
5. Kuwahara C., Takeuchi A.M., Nishimura T., Haraguchi K., Kubosaki A., Matsumoto Y., Saeki K., Matsumoto Y., Yokoyama T., Itohara S., and Onodera T. Prions prevent neuronal cell-line death. Nature 400 (1999) 225-226
6. Kim B.H., Lee H.G., Choi J.K., Kim J.I., Choi E.K., Carp R.I., and Kim Y.S. The cellular prion protein (PrPC) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation. Brain Res. Mol. Brain Res. 124 (2004) 40-50
7. Roucou X., Giannopoulos P.N., Zhang Y., Jodoin J., Goodyer C.G., and LeBlanc A. Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells. Cell Death Differ. 12 (2005) 783-795
8. Bounhar Y., Zhang Y., Goodyer C.G., and LeBlanc A. Prion protein protects human neurons against Bax-mediated apoptosis. J. Biol. Chem. 276 (2001) 39145-39149
9. Paitel E., Fahraeus R., and Checler F. Cellular prion protein sensitizes neurons to apoptotic stimuli through Mdm2-regulated and p53-dependent caspase 3-like activation. J. Biol. Chem. 278 (2003) 10061-10066
10. Paitel E., Sunyach C., Alves da Costa C., Bourdon J.C., Vincent B., and Checler F. Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels. J. Biol. Chem. 279 (2004) 612-618
11. Rossi D., Cozzio A., Flechsig E., Klein M.A., Rulicke T., Aguzzi A., and Weissmann C. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J. 20 (2001) 694-702
12. Sakaguchi S., Katamine S., Nishida N., Moriuchi R., Shigematsu K., Sugimoto T., Nakatani A., Kataoka Y., Houtani T., Shirabe S., Okada H., Hasegawa S., Miyamoto T., and Noda T. Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene. Nature 380 (1996) 528-531
13. Moore R.C., Lee I.Y., Silverman G.L., Harrison P.M., Strome R., Heinrich C., Karunaratne A., Pasternak S.H., Chishti M.A., Liang Y., Mastrangelo P., Wang K., Smit A.F., Katamine S., Carlson G.A., Cohen F.E., Prusiner S.B., Melton D.W., Tremblay P., Hood L.E., and Westaway D. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel. J. Mol. Biol. 292 (1999) 797-817
14. Castilla J., Hetz C., and Soto C. Molecular mechanisms of neurotoxicity of pathological prion protein. Curr. Mol. Med. 4 (2004) 397-403
15. Tilly G., Chapuis J., Vilette D., Laude H., and Vilotte J.L. Efficient and specific down-regulation of prion protein expression by RNAi. Biochem. Biophys. Res. Commun. 305 (2003) 548-551
16. Qin K., Zhao L., Tang Y., Bhatta S., Simard J.M., and Zhao R.Y. Doppel-induced apoptosis and counteraction by cellular prion protein in neuroblastoma and astrocytes. Neuroscience 141 (2006) 1375-1388
17. Zelivianski S., Liang D., Chen M., Mirkin B.L., and Zhao R.Y. Suppressive effect of elongation factor 2 on apoptosis induced by HIV-1 viral protein R. Apoptosis 11 (2006) 377-388
18. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
19. Koc M., Nad'ova Z., Truksa J., Ehrlichova M., and Kovar J. Iron deprivation induces apoptosis via mitochondrial changes related to Bax translocation. Apoptosis 10 (2005) 381-393
20. Chen M., Elder R.T., Yu M., O'Gorman M.G., Selig L., Benarous R., Yamamoto A., and Zhao Y. Mutational analysis of Vpr-induced G2 arrest, nuclear localization, and cell death in fission yeast. J. Virol. 73 (1999) 3236-3245
21. Zhang X.D., Gillespie S.K., and Hersey P. Staurosporine induces apoptosis of melanoma by both caspase-dependent and -independent apoptotic pathways. Mol. Cancer Ther. 3 (2004) 187-197
22. Giuliano M., Bellavia G., Lauricella M., D'Anneo A., Vassallo B., Vento R., and Tesoriere G. Staurosporine-induced apoptosis in Chang liver cells is associated with down-regulation of Bcl-2 and Bcl-XL. Int J. Mol. Med. 13 (2004) 565-571
23. Chen M., and Wang J. Initiator caspases in apoptosis signaling pathways. Apoptosis 7 (2002) 313-319
24. Borchelt D.R., Scott M., Taraboulos A., Stahl N., and Prusiner S.B. Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J. Cell Biol. 110 (1990) 743-752
25. Paitel E., Alves da Costa C., Vilette D., Grassi J., and Checler F. Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies. J. Neurochem. 83 (2002) 1208-1214
26. Diarra-Mehrpour M., Arrabal S., Jalil A., Pinson X., Gaudin C., Pietu G., Pitaval A., Ripoche H., Eloit M., Dormont D., and Chouaib S. Prion protein prevents human breast carcinoma cell line from tumor necrosis factor alpha-induced cell death. Cancer Res. 64 (2004) 719-727
27. Roucou X., Gains M., and LeBlanc A.C. Neuroprotective functions of prion protein. J. Neurosci. Res. 75 (2004) 153-161