Determination of metformin in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3695-3700

  Liu, Ang ^a   Coleman, Stuart P ^a  

^a BIOS Laboratories   (United States)

Author keywords

GLP; HILIC; LC MS MS; Metformin; Method validation

Indexed keywords

ACCURACY OF ANALYSIS; ANALYTES; CORRELATION COEFFICIENT; EXTRACTION RECOVERY; FREEZE-THAW CYCLES; HUMAN PLASMAS; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHIES; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LC-MS/MS; LINEAR LEAST SQUARES; LINEAR RANGE; LOWER LIMIT OF QUANTIFICATIONS; METFORMINS; METHOD VALIDATIONS; MULTIPLE REACTION MONITORING; PLASMA SAMPLES; PROTEIN PRECIPITATION; QUANTITATIVE ANALYSIS; RAPID ASSAY; ROOM TEMPERATURE; TANDEM MASS SPECTROMETRY;

ACETONITRILE; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; FORMIC ACID; HYDROPHILICITY; INDUSTRIAL LABORATORIES; IONIC LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; ORGANIC ACIDS; PLASMA (HUMAN); PLASMAS; PROTEINS;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

METFORMIN;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; HYDROPHILICITY; LIQUID CHROMATOGRAPHY; METHODOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, LIQUID; HUMANS; METFORMIN; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 72049113621     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.09.020     Document Type: Article

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