HPLC-UV determination of metformin in human plasma for application in pharmacokinetics and bioequivalence studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 46, Issue 1, 2008, Pages 143-147

  Porta, Valentina ^a   Schramm, Simone Grigoleto ^a   Kano, Eunice Kazue ^a   Koono, Eunice Emiko ^a   Armando, Yara Popst ^a   Fukuda, Kazuo ^a   Serra, Cristina Helena dos Reis ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bioequivalence; Human plasma; Metformin; Pharmacokinetics; Quantification; Reversed phase chromatography

Indexed keywords

ACETONITRILE; METFORMIN; PHENYL GROUP; PHOSPHATE BUFFERED SALINE; PROTEIN;

ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; DRUG MANUFACTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PLASMA; PRECIPITATION; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SPECTRAL SENSITIVITY; ULTRAVIOLET RADIATION;

ACETONITRILES; ADMINISTRATION, ORAL; AREA UNDER CURVE; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; HALF-LIFE; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; PRECIPITATION; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; THERAPEUTIC EQUIVALENCY; TIME FACTORS;

EID: 36749091680     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.10.007     Document Type: Article

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