Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 3, 2009, Pages 469-474

  Huttunen, Kristiina M ^a   Rautio, Jarkko ^a   Leppänen, Jukka ^a   Vepsäläinen, Jouko ^a   Keski Rahkonen, Pekka ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Hydrophilic interaction liquid chromatography (HILIC); Metformin; Prodrug

Indexed keywords

ACETONITRILE; AMMONIUM ACETATE; METFORMIN; PRODRUG; WATER;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SOLUBILITY; DRUG SPECIFICITY; DRUG STRUCTURE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LIPOPHILICITY; MALE; NONHUMAN; NORMAL HUMAN; PH; PRECIPITATION; PRIORITY JOURNAL; RAT; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS; SUPERNATANT; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; PRODRUGS; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS;

EID: 67650253859     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.04.033     Document Type: Article

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