Sulfonylureas uncouple glucose-dependence for GPR40-mediated enhancement of insulin secretion from INS-1E cells

Molecular and Cellular Endocrinology

Volumn 315, Issue 1-2, 2010, Pages 308-313

  Yang, Ming ^a   Chisholm, Jeffrey W ^a   Soelaiman, Sandriyana ^a   Shryock, John C ^a  

^a GILEAD SCIENCES   (United States)

Author keywords

GPR40; Insulin; L type calcium channel; S ( ) Bay K8644; Sulfonylurea

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL L TYPE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; NIFEDIPINE; SULFONYLUREA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; INSULIN RELEASE; MOLECULAR MECHANICS; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN FUNCTION;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL LINE; CYCLIC AMP; GLIPIZIDE; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; NIFEDIPINE; RATS; RECEPTORS, G-PROTEIN-COUPLED; SULFONYLUREA COMPOUNDS;

EID: 71849112933     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.09.033     Document Type: Article

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