Design and synthesis of carborane-containing androgen receptor (AR) antagonist bearing a pyridine ring

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8022-8028

  Ohta, Kiminori ^a   Goto, Tokuhito ^a   Fijii, Shinya ^b   Suzuki, Tomoharu ^c   Ohta, Shigeru ^c   Endo, Yasuyuki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Androgen receptor ligand; Antagonist; Binding; Transcriptional activation

Indexed keywords

1 HYDROXYMETHYL 12 (2 PYRIDYL) 1,12 DICARBA CLOSO DODECABORANE; 1 HYDROXYMETHYL 12 (2 PYRIDYLMETHYL) 1,12 DICARBA CLOSO DODECABORANE; 1 HYDROXYMETHYL 12 (3 PYRIDYL) 1,12 DICARBA CLOSO DODECABORANE; 1 HYDROXYMETHYL 12 (3 PYRIDYLMETHYL) 1,12 DICARBA CLOSO DODECABORANE; 1 HYDROXYMETHYL 12 (4 PYRIDYL) 1,12 DICARBA CLOSO DODECABORANE; 1 HYDROXYMETHYL 12 (4 PYRIDYLMETHYL) 1,12 DICARBA CLOSO DODECABORANE; ANTIANDROGEN; BICALUTAMIDE; CARBORANE DERIVATIVE; FLUTAMIDE; PYRIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; PHARMACOPHORE; TRANSCRIPTION INITIATION;

ANDROGEN ANTAGONISTS; ANILIDES; ANIMALS; BINDING, COMPETITIVE; BORANES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FLUTAMIDE; HUMANS; HYDROPHOBICITY; MICE; MOLECULAR STRUCTURE; NIH 3T3 CELLS; NITRILES; PYRIDINES; RECEPTORS, ANDROGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOSYL COMPOUNDS; TRANSFECTION;

EID: 50349103360     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.055     Document Type: Article

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