Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)

Applied Radiation and Isotopes

Volumn 68, Issue 2, 2010, Pages 325-328

  Valdivia, Ana C ^a   Mason, Samantha ^a   Collins, Jeffrey ^a   Buckley, Kenneth R ^b   Coletta, Paul ^a   Beanlands, Rob S ^a,c   DaSilva, Jean N ^a,c  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b TRIUMF   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Carbon 11; Fasudil; Hydroxyfasudil; Intracellular labeling; Rho kinases

Indexed keywords

CARBON-11; CHEMICAL PURITY; DEPROTECTION; METHYL IODIDE; ONE POT; PROTECTING GROUP; RADIOSYNTHESIS; SPECIFIC RADIOACTIVITY;

CROWN ETHERS; FLUORINE CONTAINING POLYMERS; LABELING; SODIUM; SYNTHESIS (CHEMICAL);

RADIOACTIVE TRACERS;

BENZO 15 CROWN 5 DERIVATIVE; CARBON 11; FASUDIL; HYDROXYFASUDIL; METHYL IODIDE; RHO KINASE; TRACER;

ARTICLE; CONTROLLED STUDY; DRUG PURITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHEMISTRY;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; FEASIBILITY STUDIES; IMAGE ENHANCEMENT; ISOTOPE LABELING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RHO-ASSOCIATED KINASES;

EID: 71849107277     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2009.11.002     Document Type: Article

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