An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2-/- γc-/- mouse

Clinical and Experimental Metastasis

Volumn 26, Issue 7, 2009, Pages 673-684

  Le Dévédec, Sylvia E ^a   Van Roosmalen, Wies ^a   Maria, Naomi ^a   Grimbergen, Max ^a   Pont, Chantal ^a   Lalai, Reshma ^a   Van De Water, Bob ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

4T1 cells; Breast cancer; EGF receptor; ErbB1; Immune deficient mice; Metastasis; MTLn3 cells

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; RAG2 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; FEMALE; FISCHER 344 RAT; LUNG METASTASIS; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUDE MOUSE; RAT; SCID MOUSE;

ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; KILLER CELLS, NATURAL; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, SCID; NEOPLASM METASTASIS; RATS;

EID: 71849107124     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-009-9267-6     Document Type: Article

References (58)

1. J Ferlay P Autier M Boniol, et al. 2007 Estimates of the cancer incidence and mortality in Europe in 2006 Ann Oncol 18 581 592 10.1093/annonc/mdl498 10.1093/annonc/mdl498 17287242 (Pubitemid 46359643)
2. K Pantel RH Brakenhoff 2004 Dissecting the metastatic cascade Nat Rev Cancer 4 448 456 10.1038/nrc1370 10.1038/nrc1370 15170447
3. GP Gupta J Massague 2006 Cancer metastasis: building a framework Cell 127 679 695 10.1016/j.cell.2006.11.001 10.1016/j.cell.2006.11.001 17110329 (Pubitemid 44781029)
4. MJ van Nimwegen B van de Water 2007 Focal adhesion kinase: a potential target in cancer therapy Biochem Pharmacol 73 597 609 10.1016/j.bcp.2006.08.011 10.1016/j.bcp.2006.08.011 16997283 (Pubitemid 46161372)
5. T Vargo-Gogola JM Rosen 2007 Modelling breast cancer: one size does not fit all Nat Rev Cancer 7 659 672 10.1038/nrc2193 10.1038/nrc2193 17721431 (Pubitemid 47327411)
6. X Cao EW Shores J Hu-Li, et al. 1995 Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain Immunity 2 223 238 10.1016/1074-7613(95)90047-0 10.1016/1074-7613(95)90047-0 7697543
7. C Khanna K Hunter 2005 Modeling metastasis in vivo Carcinogenesis 26 513 523 10.1093/carcin/bgh261 10.1093/carcin/bgh261 15358632 (Pubitemid 41214139)
8. NE Sharpless RA Depinho 2006 The mighty mouse: genetically engineered mouse models in cancer drug development Nat Rev Drug Discov 5 741 754 10.1038/nrd2110 10.1038/nrd2110 16915232 (Pubitemid 44323701)
9. PD Ottewell RE Coleman I Holen 2006 From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies Breast Cancer Res Treat 96 101 113 10.1007/s10549-005-9067- x 10.1007/s10549-005-9067-x 16319986
10. A Neri D Welch T Kawaguchi, et al. 1982 Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma J Natl Cancer Inst 68 507 517 6950180
11. H Marxfeld F Staedtler JH Harleman 2006 Characterisation of two rat mammary tumour models for breast cancer research by gene expression profiling Exp Toxicol Pathol 58 133 143 10.1016/j.etp.2006.05.003 10.1016/j.etp.2006.05. 003 16857353 (Pubitemid 44635150)
12. NE Hynes HA Lane 2005 ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 5 341 354 10.1038/nrc1609 10.1038/nrc1609 15864276 (Pubitemid 40637826)
13. V Giancotti 2006 Breast cancer markers Cancer Lett 243 145 159 10.1016/j.canlet.2006.01.035 10.1016/j.canlet.2006.01.035 16530325 (Pubitemid 44485857)
14. J Condeelis JE Segall 2003 Intravital imaging of cell movement in tumours Nat Rev Cancer 3 921 930 10.1038/nrc1231 10.1038/nrc1231 14737122
15. J Condeelis RH Singer JE Segall 2005 The great escape: when cancer cells hijack the genes for chemotaxis and motility Annu Rev Cell Dev Biol 21 695 718 10.1146/annurev.cellbio.21.122303.120306 10.1146/annurev.cellbio.21.122303. 120306 16212512 (Pubitemid 41740651)
16. C Xue J Wyckoff F Liang, et al. 2006 Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis Cancer Res 66 192 197 10.1158/0008-5472.CAN-05-1242 10.1158/0008-5472.CAN-05-1242 16397232 (Pubitemid 43166025)
17. A Cerwenka LL Lanier 2001 Natural killer cells, viruses and cancer Nat Rev Immunol 1 41 49 10.1038/35095564 10.1038/35095564 11905813
18. A Garofalo RG Chirivi E Scanziani, et al. 1993 Comparative study on the metastatic behavior of human tumors in nude, beige/nude/xid and severe combined immunodeficient mice Invasion Metastasis 13 82 91 8225855
19. FE Sharkey J Fogh 1979 Incidence and pathological features of spontaneous tumors in athymic nude mice Cancer Res 39 833 839 427772
20. A Sebesteny J Taylor-Papadimitriou R Ceriani, et al. 1979 Primary human breast carcinomas transplantable in the nude mouse J Natl Cancer Inst 63 1331 1337 92586
21. B Rae-Venter LM Reid 1980 Growth of human breast carcinomas in nude mice and subsequent establishment in tissue culture Cancer Res 40 95 100 6243091
22. RA Phillips MA Jewett BL Gallie 1989 Growth of human tumors in immune-deficient scid mice and nude mice Curr Top Microbiol Immunol 152 259 263 2805794
23. AL Zietman E Sugiyama JR Ramsay, et al. 1991 A comparative study on the xenotransplantability of human solid tumors into mice with different genetic immune deficiencies Int J Cancer 47 755 759 10.1002/ijc.2910470522 10.1002/ijc.2910470522 2004856
24. T Kubota H Yamaguchi M Watanabe, et al. 1993 Growth of human tumor xenografts in nude mice and mice with severe combined immunodeficiency (SCID) Surg Today 23 375 377 10.1007/BF00309059 10.1007/BF00309059 8391349
25. R Clarke 1996 Human breast cancer cell line xenografts as models of breast cancer. The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines Breast Cancer Res Treat 39 69 86 10.1007/BF01806079 10.1007/BF01806079 8738607 (Pubitemid 26136505)
26. MJ van Nimwegen S Verkoeijen L van Buren, et al. 2005 Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation Cancer Res 65 4698 4706 10.1158/0008-5472.CAN-04-4126 10.1158/0008-5472.CAN-04-4126 15930288 (Pubitemid 40740806)
27. MJ van Nimwegen S Verkoeijen PJ Kuppen, et al. 1981 An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis Clin Exp Metastasis 24 5 379 387 10.1007/s10585-007-9075-9
28. A Neri GL Nicolson 1981 Phenotypic drift of metastatic and cell-surface properties of mammary adenocarcinoma cell clones during growth in vitro Int J Cancer 28 731 738 10.1002/ijc.2910280612 10.1002/ijc.2910280612 7037655
29. M Huigsloot IB Tijdens GJ Mulder, et al. 2002 Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells J Biol Chem 277 35869 35879 10.1074/jbc.M200378200 10.1074/jbc.M200378200 12107157
30. JS Condeelis J Wyckoff JE Segall 2000 Imaging of cancer invasion and metastasis using green fluorescent protein Eur J Cancer 36 1671 1680 10.1016/S0959-8049(00)00155-6 10959053 (Pubitemid 30616371)
31. JB Wyckoff JG Jones JS Condeelis, et al. 2000 A critical step in metastasis: in vivo analysis of intravasation at the primary tumor Cancer Res 60 2504 2511 10811132
32. Y Shinkai G Rathbun KP Lam, et al. 1992 RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement Cell 68 855 867 10.1016/0092-8674(92)90029-C 10.1016/0092-8674(92)90029-C 1547487
33. J Wyckoff W Wang EY Lin, et al. 2004 A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors Cancer Res 64 7022 7029 10.1158/0008-5472.CAN-04-1449 10.1158/0008-5472.CAN-04-1449 15466195 (Pubitemid 39331012)
34. JB Wyckoff Y Wang EY Lin, et al. 2007 Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors Cancer Res 67 2649 2656 10.1158/0008-5472.CAN-06-1823 10.1158/0008-5472.CAN-06-1823 17363585 (Pubitemid 46548952)
35. J Roder A Duwe 1979 The beige mutation in the mouse selectively impairs natural killer cell function Nature 278 451 453 10.1038/278451a0 10.1038/278451a0 313007 (Pubitemid 9130703)
36. JC Roder 1979 The beige mutation in the mouse I A stem cell predetermined impairment in natural killer cell function J Immunol 123 2168 2173 489978
37. K Tao M Fang J Alroy, et al. 2008 Imagable 4T1 model for the study of late stage breast cancer BMC Cancer 8 228 10.1186/1471-2407-8-228 10.1186/1471-2407-8-228 18691423
38. J Wu LL Lanier 2003 Natural killer cells and cancer Adv Cancer Res 90 127 156 10.1016/S0065-230X(03)90004-2 10.1016/S0065-230X(03)90004-2 14710949 (Pubitemid 37549223)
39. S Ben Eliyahu GG Page R Yirmiya, et al. 1996 Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis Nat Med 2 457 460 10.1038/nm0496-457 10.1038/nm0496-457 8597957 (Pubitemid 26191918)
40. S Ben Eliyahu GG Page R Yirmiya, et al. 1999 Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity Int J Cancer 80 880 888 10.1002/(SICI)1097-0215(19990315)80: 6<880::AID-IJC14>3.0.CO;2-Y 10.1002/(SICI)1097-0215(19990315)80:6<880:: AID-IJC14>3.0.CO;2-Y 10074922
41. B Bouzahzah C Albanese F Ahmed, et al. 2001 Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways Mol Med 7 816 830 11844870
42. R Melamed E Rosenne K Shakhar, et al. 2005 Marginating pulmonary-NK activity and resistance to experimental tumor metastasis: suppression by surgery and the prophylactic use of a beta-adrenergic antagonist and a prostaglandin synthesis inhibitor Brain Behav Immun 19 114 126 10.1016/j.bbi.2004.07.004 10.1016/j.bbi.2004.07.004 15664784 (Pubitemid 40138646)
43. MZ Dewan H Terunuma S Ahmed, et al. 2005 Natural killer cells in breast cancer cell growth and metastasis in SCID mice Biomed Pharmacother 59 Suppl 2 S375 S379 10.1016/S0753-3322(05)80082-4 10.1016/S0753-3322(05)80082-4 16507413 (Pubitemid 43303908)
44. P Beckhove F Schutz IJ Diel, et al. 2003 Efficient engraftment of human primary breast cancer transplants in nonconditioned NOD/Scid mice Int J Cancer 105 444 453 10.1002/ijc.11125 10.1002/ijc.11125 12712433 (Pubitemid 36578546)
45. Zhang B, Duan Z, Zhao Y (2008) Mouse models with human immunity and their application in biomedical research. J Cell Mol Med. doi: 10.1111/j.1582-4934. 2008.00347.x
46. J Condeelis JW Pollard 2006 Macrophages: obligate partners for tumor cell migration, invasion, and metastasis Cell 124 263 266 10.1016/j.cell.2006.01.007 10.1016/j.cell.2006.01.007 16439202 (Pubitemid 43121975)
47. TM Robinson-Smith I Isaacsohn CA Mercer, et al. 2007 Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice Cancer Res 67 5708 5716 10.1158/0008-5472.CAN-06-4375 10.1158/0008-5472.CAN-06-4375 17575137 (Pubitemid 46985003)
48. O Peyruchaud B Winding I Pecheur, et al. 2001 Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions J Bone Miner Res 16 2027 2034 10.1359/jbmr.2001.16.11.2027 10.1359/jbmr.2001.16.11.2027 11697798
49. A Wetterwald G van der Pluijm I Que, et al. 2002 Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease Am J Pathol 160 1143 1153 11891210
50. K Sossey-Alaoui A Safina X Li, et al. 2007 Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells Am J Pathol 170 2112 2121 10.2353/ajpath.2007.060975 10.2353/ajpath.2007. 060975 17525277 (Pubitemid 47339283)
51. M Lelekakis JM Moseley TJ Martin, et al. 1999 A novel orthotopic model of breast cancer metastasis to bone Clin Exp Metastasis 17 163 170 10.1023/A:1006689719505 10.1023/A:1006689719505 10411109 (Pubitemid 29335443)
52. ME Gershwin B Merchant MC Gelfand, et al. 1975 The natural history and immunopathology of outbred athymic (nude) mice Clin Immunol Immunopathol 4 324 340 10.1016/0090-1229(75)90002-1 10.1016/0090-1229(75)90002-1 1104226
53. JM McCune R Namikawa H Kaneshima, et al. 1988 The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function Science 241 1632 1639 10.1126/science.2971269 10.1126/science.2971269 2971269
54. K Dorshkind SB Pollack MJ Bosma, et al. 1985 Natural killer (NK) cells are present in mice with severe combined immunodeficiency (scid) J Immunol 134 3798 3801 3989296
55. W Schuler MJ Bosma 1989 Nature of the scid defect: a defective VDJ recombinase system Curr Top Microbiol Immunol 152 55 62 2805798
56. DE Mosier KL Stell RJ Gulizia, et al. 1993 Homozygous scid/scid; beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation J Exp Med 177 191 194 10.1084/jem.177.1.191 10.1084/jem.177.1. 191 8418200 (Pubitemid 23008099)
57. F Colucci C Soudais E Rosmaraki, et al. 1999 Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation J Immunol 162 2761 2765 10072522
58. PD Greenberg SR Riddell 1999 Deficient cellular immunity-finding and fixing the defects Science 285 546 551 10.1126/science.285.5427.546 10.1126/science.285.5427.546 10417377 (Pubitemid 29352918)