N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 24, 2009, Pages 6952-6956

  Bowers, Simeon ^a   Probst, Gary D ^a   Truong, Anh P ^a   Hom, Roy K ^a   Konradi, Andrei W ^a   Sham, Hing L ^a   Garofalo, Albert W ^a   Wong, Karina ^a   Goldbach, Erich ^a   Quinn, Kevin P ^a   Sauer, John Michael ^a   Wallace, William ^a   Nguyen, Lan ^a   Hemphill, Susanna S ^a   Bova, Michael P ^a   Basi, Guriqbal S ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

Secretase inhibitor; Alzheimer's disease; Bicyclic sulfonamides

Indexed keywords

GAMMA SECRETASE INHIBITOR; SULFONAMIDE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG STABILITY; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; BICYCLO COMPOUNDS; HUMANS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 71849104271     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.060     Document Type: Article

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