A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 2, 2005, Pages 373-378

  Lewis, Stephen J ^a   Smith, Adrian L ^a   Neduvelil, Joseph G ^a   Stevenson, Graeme I ^a   Lindon, Matthew J ^a   Jones, A Brian ^a   Shearman, Mark S ^a   Beher, Dirk ^a   Clarke, Earl ^a   Best, Jonathan D ^a   Peachey, James E ^a   Harrison, Timothy ^a   Castro, J Luis ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Secretase inhibitors

Indexed keywords

5 CHLORO 2 THIENYLSULFONAMIDE; BENZENE DERIVATIVE; GAMMA SECRETASE INHIBITOR; SULFANILAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN;

ALKANES; ALZHEIMER DISEASE; AMIDES; AMINES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; ENDOPEPTIDASES; HETEROCYCLIC COMPOUNDS; MICE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10644297980     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.062     Document Type: Article

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