Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 3010-3013

  Guo, Tao ^a   Gu, Huizhong ^a   Hobbs, Doug W ^a   Rokosz, Laura L ^a   Stauffer, Tara M ^a   Jacob, Biji ^a   Clader, John W ^b  

^a PHARMACOPEIA INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Secretase inhibitors; Alzheimer's disease

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; CARBAMIC ACID DERIVATIVE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; PYRROLIDINE SULFONAMIDE CARBAMATE DERIVATIVE; TETRAHYDROQUINOLINE SULFONAMIDE CARBAMATE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DISEASE COURSE; DRUG DESIGN; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; CARBAMATES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; PYRROLIDINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 34247893953     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.055     Document Type: Article

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