Synthesis and biological evaluation of the metabolites of 2-(1-{3-[(6-chloronaphthalen-2-yl)sulfonyl]propanoyl}piperidin-4-yl)-5-methyl-1,2-dihydro-3H-imidazo[1,5-c]imidazol-3-one

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 7993-8002

  Fujimoto, Takuya ^a   Tobisu, Mamoru ^a   Konishi, Noriko ^a   Kawamura, Masaki ^a   Tada, Norio ^a   Takagi, Terufumi ^a   Kubo, Keiji ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Active metabolite; Antithrombotic agent; Factor Xa inhibitor

Indexed keywords

2 [1 [3 [(6 CHLORONAPHTHALEN 2 YL)SULFONYL] 2 HYDROXYPROPANOYL]PIPERIDIN 4 YL] 5 METHYL 1,2 DIHYDRO 3H IMIDAZO[1,5 C]IMIDAZOL 3 ONE; 2 [1 [3 [(6 CHLORONAPHTHALEN 2 YL)SULFONYL]PROPANOYL]PIPERIDIN 4 YL] 5 (HYDROXYMETHYL) 1,2 DIHYDRO 3H IMIDAZO[1,5 C]IMIDAZOL 3 ONE; 2 [1 [3 [(6 CHLORONAPHTHALEN 2 YL)SULFONYL]PROPANOYL]PIPERIDIN 4 YL] 5 METHYL 1,2 DIHYDRO 3H IMIDAZO[1,5 C]IMIDAZOL 3 ONE; BLOOD CLOTTING FACTOR 10A INHIBITOR; IMIDAZOLE DERIVATIVE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; MALE; MONKEY; NONHUMAN;

ANIMALS; ANTICOAGULANTS; AREA UNDER CURVE; FACTOR XA; HUMANS; IMIDAZOLES; MACACA FASCICULARIS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PIPERIDINES; SPECTROPHOTOMETRY, INFRARED;

EID: 71849090412     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.009     Document Type: Article

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