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Volumn 4, Issue 3, 2003, Pages 272-281

Factor Xa inhibitors: Today and beyond

Author keywords

Anticoagulants; Antithrombotics; Factor Xa inhibitors

Indexed keywords

1 [3 (AMINOMETHYL)PHENYL] N [3 FLUORO 2' (METHYLSULFONYL)[1,1' BIPHENYL] 4 YL] 3 (TRIFLUOROMETHYL) 1H PYRAZOLE 5 CARBOXAMIDE; 2 [4 [(1 ACETIMIDOYL 3 PYRROLIDINYL)OXY]PHENYL] 3 (7 AMIDINO 2 NAPHTHYL)PROPIONIC ACID; [N [4 [(1 ACETIMIDOYL 4 PIPERIDYL)OXY]PHENYL] N [(7 AMIDINO 2 NAPHTHYL)METHYL]SULFAMOYL]ACETIC ACID; ANTICOAGULANT AGENT; ANTISTASIN; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; DPC 602; FIBRIN; FONDAPARINUX; HIRUDIN; IDRAPARINUX; KFA 1829; KFA 1982; N [1 (2 AMINOIMINOMETHYL 4 THIENYLMETHYL) 2 OXO 3 PYRROLIDINYL] 7 METHOXY N METHYL 2 NAPHTHALENESULFONAMIDE; N [2 (5 AMIDINO 2 HYDROXYPHENOXY) 3,5 DIFLUORO 6 [3 (1 METHYL 1H 2 IMIDAZOLIN 2 YL)PHENOXY] 4 PYRIDINYL] N METHYLGLYCINE; RECOMBINANT NEMATODE ANTICOAGULANT PROTEIN C2; RECOMBINANT TICK ANTICOAGULANT PEPTIDE; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; RIVAROXABAN; RPR 128515; RPR 130737; SERINE PROTEINASE; SR 123781; SR 907107A; THROMBIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; YAGIN;

EID: 0037962878     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (70)

References (120)
  • 2
    • 0031729333 scopus 로고    scopus 로고
    • New antithrombotic agents
    • Weitz JI, Hirsh J: New antithrombotic agents. Chest (1998) 114(5 Suppl):715S-727S.
    • (1998) Chest , vol.114 , Issue.5 SUPPL.
    • Weitz, J.I.1    Hirsh, J.2
  • 3
    • 0024328497 scopus 로고
    • Synthetic inhibitors of bovine Factor Xa and thrombin comparison of their anticoagulant efficiency
    • Stürzebecher J, Stürzebecher U, Vieweg H, Wagner G, Hauptmann J, Markwardt F: Synthetic inhibitors of bovine Factor Xa and thrombin comparison of their anticoagulant efficiency. Thromb Res (1989) 54(3):245-252.
    • (1989) Thromb Res , vol.54 , Issue.3 , pp. 245-252
    • Stürzebecher, J.1    Stürzebecher, U.2    Vieweg, H.3    Wagner, G.4    Hauptmann, J.5    Markwardt, F.6
  • 4
    • 0025214647 scopus 로고
    • Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and Factor Xa inhibitors
    • Hauptmann J, Kaiser B, Nowak G, Stürzebecher J, Markwardt F: Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and Factor Xa inhibitors. Thromb Haemost (1990) 63(2):220-223.
    • (1990) Thromb Haemost , vol.63 , Issue.2 , pp. 220-223
    • Hauptmann, J.1    Kaiser, B.2    Nowak, G.3    Stürzebecher, J.4    Markwardt, F.5
  • 5
    • 0029835392 scopus 로고    scopus 로고
    • A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators
    • A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators. N Engl J Med (1996) 335(11):775-782.
    • (1996) N Engl J Med , vol.335 , Issue.11 , pp. 775-782
  • 6
    • 0029788104 scopus 로고    scopus 로고
    • Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial
    • Antman EM: Hirudin in acute myocardial infarction. Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9B trial. Circulation (1996) 94(5):911-921.
    • (1996) Circulation , vol.94 , Issue.5 , pp. 911-921
    • Antman, E.M.1
  • 7
    • 0028946949 scopus 로고
    • Factor Xa inhibitors as novel antithrombotic agents: Facts and perspectives
    • Kaiser B, Hauptman J: Factor Xa inhibitors as novel antithrombotic agents: Facts and perspectives. Cardiovasc Drug Rev (1994) 12(3):225-236.
    • (1994) Cardiovasc Drug Rev , vol.12 , Issue.3 , pp. 225-236
    • Kaiser, B.1    Hauptman, J.2
  • 8
    • 0031412416 scopus 로고    scopus 로고
    • Factor Xa versus Factor IIa inhibitors
    • Kaiser B: Factor Xa versus Factor IIa inhibitors. Clin Appl Thrombosis/Hemostasis (1997) 3(1):16-24.
    • (1997) Clin Appl Thrombosis/Hemostasis , vol.3 , Issue.1 , pp. 16-24
    • Kaiser, B.1
  • 9
    • 0038823177 scopus 로고    scopus 로고
    • Pharmacologic modulation of human clots associated thrombin and prothrombinase activities by a direct anti Xa drug, r-hirudin and low molecular weight heparin
    • Meddahi S, Bara L, Uzan A, Samama MM: Pharmacologic modulation of human clots associated thrombin and prothrombinase activities by a direct anti Xa drug, r-hirudin and low molecular weight heparin. Haemostasis (1996) 26(Suppl):578.
    • (1996) Haemostasis , vol.26 , Issue.SUPPL. , pp. 578
    • Meddahi, S.1    Bara, L.2    Uzan, A.3    Samama, M.M.4
  • 10
    • 0037808810 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor as a modulator of post-surgical thrombogenesis. Experimental and clinical studies
    • Doctoral Thesis, University of London, London, UK, October
    • Hoppensteadt D: Tissue factor pathway inhibitor as a modulator of post-surgical thrombogenesis. Experimental and clinical studies. Doctoral Thesis, University of London, London, UK, October (1996).
    • (1996)
    • Hoppensteadt, D.1
  • 11
    • 0025146426 scopus 로고
    • Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors
    • Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J: Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors. J Clin Invest (1990) 86(2):385-391.
    • (1990) J Clin Invest , vol.86 , Issue.2 , pp. 385-391
    • Weitz, J.I.1    Hudoba, M.2    Massel, D.3    Maraganore, J.4    Hirsh, J.5
  • 12
    • 0027199974 scopus 로고
    • Importance of Factor Xa in determining the procoagulant activity of whole-blood clots
    • Eisenberg PR, Siegel JE, Abendschein DR, Miletich JP: Importance of Factor Xa in determining the procoagulant activity of whole-blood clots. J Clin Invest (1993) 91(5):1877-1883.
    • (1993) J Clin Invest , vol.91 , Issue.5 , pp. 1877-1883
    • Eisenberg, P.R.1    Siegel, J.E.2    Abendschein, D.R.3    Miletich, J.P.4
  • 13
    • 0029087535 scopus 로고
    • Role of thrombin compared with Factor Xa in the procoagulant activity of whole blood clots
    • Prager NA, Abendschein DR, McKenzie CR, Eisenberg PR: Role of thrombin compared with Factor Xa in the procoagulant activity of whole blood clots. Circulation (1995) 92(4):962-967.
    • (1995) Circulation , vol.92 , Issue.4 , pp. 962-967
    • Prager, N.A.1    Abendschein, D.R.2    McKenzie, C.R.3    Eisenberg, P.R.4
  • 14
    • 0029816710 scopus 로고    scopus 로고
    • Sustained inhibition of whole-blood clot procoagulant activity by inhibition of thrombus-associated Factor Xa
    • McKenzie CR, Abendschein DR, Eisenberg PR: Sustained inhibition of whole-blood clot procoagulant activity by inhibition of thrombus-associated Factor Xa. Arterioscler Thromb Vasc Biol (1996) 16(10):1285-1291.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , Issue.10 , pp. 1285-1291
    • McKenzie, C.R.1    Abendschein, D.R.2    Eisenberg, P.R.3
  • 15
    • 0026612517 scopus 로고
    • The restenosis paradigm revisited: An alternative proposal for cellular mechanisms
    • Schwartz RS, Holmes DR Jr, Topol EJ: The restenosis paradigm revisited: An alternative proposal for cellular mechanisms. J Am Coll Cardiol (1992) 20(5):1284-1293.
    • (1992) J Am Coll Cardiol , vol.20 , Issue.5 , pp. 1284-1293
    • Schwartz, R.S.1    Holmes D.R., Jr.2    Topol, E.J.3
  • 16
    • 0001484969 scopus 로고
    • Cellular effects of thrombin and their signaling pathways
    • Kanthou C, Benzakour O: Cellular effects of thrombin and their signaling pathways. Cell Pharmacol (1995) 2:293-302.
    • (1995) Cell Pharmacol , vol.2 , pp. 293-302
    • Kanthou, C.1    Benzakour, O.2
  • 17
    • 0003071101 scopus 로고    scopus 로고
    • Cellular and molecular events in atherogenesis: Basis for pharmacological and gene therapy approaches to restenosis
    • Benzakour O, Kanthou C: Cellular and molecular events in atherogenesis: Basis for pharmacological and gene therapy approaches to restenosis. Cell Pharmacol (1996) 3:7-22.
    • (1996) Cell Pharmacol , vol.3 , pp. 7-22
    • Benzakour, O.1    Kanthou, C.2
  • 19
    • 0029780287 scopus 로고    scopus 로고
    • Coagulation Factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat
    • Ko FN, Yang YC, Huang SC, Ou JT: Coagulation Factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat. J Clin Invest (1996) 98(6):1493-1501.
    • (1996) J Clin Invest , vol.98 , Issue.6 , pp. 1493-1501
    • Ko, F.N.1    Yang, Y.C.2    Huang, S.C.3    Ou, J.T.4
  • 20
    • 0026535444 scopus 로고
    • Coagulation Factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells
    • Gasic GP, Arenas CP, Gasic TB, Gasic GJ: Coagulation Factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells. Proc Natl Acad Sci USA (1992) 89(6):2317-2320.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.6 , pp. 2317-2320
    • Gasic, G.P.1    Arenas, C.P.2    Gasic, T.B.3    Gasic, G.J.4
  • 22
    • 0029871211 scopus 로고    scopus 로고
    • Neointimal thickening after severe coronary artery injury is limited by short-term administration of a Factor Xa inhibitor. Results in a porcine model
    • Schwartz RS, Holder DJ, Holmes DR, Veinot JP, Camrud AR, Jorgenson MA, Johnson RG: Neointimal thickening after severe coronary artery injury is limited by short-term administration of a Factor Xa inhibitor. Results in a porcine model. Circulation (1996) 93(8):1542-1548.
    • (1996) Circulation , vol.93 , Issue.8 , pp. 1542-1548
    • Schwartz, R.S.1    Holder, D.J.2    Holmes, D.R.3    Veinot, J.P.4    Camrud, A.R.5    Jorgenson, M.A.6    Johnson, R.G.7
  • 23
    • 0034922431 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor activity in severe sepsis
    • Creasey AA, Reinhart K: Tissue factor pathway inhibitor activity in severe sepsis. Crit Care Med (2001) 29(7 Suppl):S126-129.
    • (2001) Crit Care Med , vol.29 , Issue.7 SUPPL.
    • Creasey, A.A.1    Reinhart, K.2
  • 24
    • 0033816376 scopus 로고    scopus 로고
    • Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis
    • Abraham E: Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis. Crit Care Med (2000) 28(9 Suppl):S31-33.
    • (2000) Crit Care Med , vol.28 , Issue.9 SUPPL.
    • Abraham, E.1
  • 25
    • 0038146467 scopus 로고    scopus 로고
    • Chiron announces results of phase III study of tifacogin in severe sepsis
    • 21 November
    • Chiron Corp: Chiron announces results of phase III study of tifacogin in severe sepsis.Press Release 21 November (2001).
    • (2001) Press Release
  • 26
    • 0038146466 scopus 로고    scopus 로고
    • Corvas International presents results of phase IIa clinical trial of rNAPc2 anticoagulant in elective angioplasty
    • 05 December
    • Corvas International Inc: Corvas International presents results of phase IIa clinical trial of rNAPc2 anticoagulant in elective angioplasty. Press Release 05 December (2001).
    • (2001) Press Release
  • 27
    • 0037808809 scopus 로고    scopus 로고
    • Programs & markets: Cardiovascular
    • 01 March
    • Corvas International Inc: Programs & markets: Cardiovascular. Company World Wide Web Site 01 March (2003). http://www.corvas.com/programs-markets.html
    • (2003)
  • 28
    • 0028269097 scopus 로고
    • DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for Factor Xa
    • Hara T, Yokoyama A, Ishihara H, Yokoyama Y, Nagahara T, Iwamoto M: DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for Factor Xa. Thromb Haemost (1994) 71 (3):314-319.
    • (1994) Thromb Haemost , vol.71 , Issue.3 , pp. 314-319
    • Hara, T.1    Yokoyama, A.2    Ishihara, H.3    Yokoyama, Y.4    Nagahara, T.5    Iwamoto, M.6
  • 29
    • 0029112614 scopus 로고
    • Antithrombotic effects of orally active synthetic antagonist of activated Factor X in nonhuman primates
    • Yokoyama T, Kelly AB, Marzec UM, Hanson SR, Kunitada S, Harker LA: Antithrombotic effects of orally active synthetic antagonist of activated Factor X in nonhuman primates. Circulation (1995) 92(3):485-491.
    • (1995) Circulation , vol.92 , Issue.3 , pp. 485-491
    • Yokoyama, T.1    Kelly, A.B.2    Marzec, U.M.3    Hanson, S.R.4    Kunitada, S.5    Harker, L.A.6
  • 30
    • 0029111442 scopus 로고
    • DX-9065a, an orally active, specific inhibitor of Factor Xa, inhibits thrombosis without affecting bleeding time in rats
    • Hara T, Yokoyama A, Tanabe K, Ishihara H, Iwamoto M: DX-9065a, an orally active, specific inhibitor of Factor Xa, inhibits thrombosis without affecting bleeding time in rats. Thromb Haemost (1995) 74(2):635-639.
    • (1995) Thromb Haemost , vol.74 , Issue.2 , pp. 635-639
    • Hara, T.1    Yokoyama, A.2    Tanabe, K.3    Ishihara, H.4    Iwamoto, M.5
  • 31
    • 0037808807 scopus 로고
    • Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of Factor Xa against experimental disseminated intravascular coagulation in rats
    • Yamazaki M, Asakura H, Saito M, Aoshima K, Morishita E, Matsuda T: Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of Factor Xa against experimental disseminated intravascular coagulation in rats. Thromb Haemost (1995) 73(Suppl):1312.
    • (1995) Thromb Haemost , vol.73 , Issue.SUPPL. , pp. 1312
    • Yamazaki, M.1    Asakura, H.2    Saito, M.3    Aoshima, K.4    Morishita, E.5    Matsuda, T.6
  • 32
    • 0029080418 scopus 로고
    • Species differences in anticoagulant and anti-Xa activity of DX-9065a, a highly selective Factor Xa inhibitor
    • Hara T, Yokoyama A, Morishima Y, Kunitada S: Species differences in anticoagulant and anti-Xa activity of DX-9065a, a highly selective Factor Xa inhibitor. Thromb Res (1995) 80(1):99-104.
    • (1995) Thromb Res , vol.80 , Issue.1 , pp. 99-104
    • Hara, T.1    Yokoyama, A.2    Morishima, Y.3    Kunitada, S.4
  • 33
    • 0033373234 scopus 로고    scopus 로고
    • Inactivation of Factor Xa by the synthetic inhibitor DX-9065a causes strong anticoagulant and antiplatelet actions in human blood
    • Kaiser B, Jeske W, Walenga JM, Fareed J: Inactivation of Factor Xa by the synthetic inhibitor DX-9065a causes strong anticoagulant and antiplatelet actions in human blood. Blood Coagul Fibrinolysis (1999) 10(8):495-501.
    • (1999) Blood Coagul Fibrinolysis , vol.10 , Issue.8 , pp. 495-501
    • Kaiser, B.1    Jeske, W.2    Walenga, J.M.3    Fareed, J.4
  • 34
    • 0030097984 scopus 로고    scopus 로고
    • DX 9065A a novel, synthetic, selective and orally active inhibitor of Factor Xa: In vitro and in vivo studies
    • note
    • Herbert JM, Bernat A, Dol F, Hérault JP, Crepon B, Lormeau JC: DX 9065A a novel, synthetic, selective and orally active inhibitor of Factor Xa: In vitro and in vivo studies. J Pharmacol Exp Ther (1996) 276(3):1030-1038. This paper describes many of the basic characteristics of DX-9065a, a Factor Xa inhibitor that is at a relatively more advanced stage in clinical development.
    • (1996) J Pharmacol Exp Ther , vol.276 , Issue.3 , pp. 1030-1038
    • Herbert, J.M.1    Bernat, A.2    Dol, F.3    Hérault, J.P.4    Crepon, B.5    Lormeau, J.C.6
  • 35
    • 0032960904 scopus 로고    scopus 로고
    • DX-9065a, an orally active Factor Xa inhibitor, does not facilitate haemorrhage induced by tail transection or gastric ulcer at the effective doses in rat thrombosis model
    • Tanabe K, Morishima Y, Shibutani T, Terada Y, Hara T, Shiohara Y, Aoyagi K, Kunitada S, Kondo T: DX-9065a, an orally active Factor Xa inhibitor, does not facilitate haemorrhage induced by tail transection or gastric ulcer at the effective doses in rat thrombosis model. Thromb Haemost (1999) 81(5):828-834.
    • (1999) Thromb Haemost , vol.81 , Issue.5 , pp. 828-834
    • Tanabe, K.1    Morishima, Y.2    Shibutani, T.3    Terada, Y.4    Hara, T.5    Shiohara, Y.6    Aoyagi, K.7    Kunitada, S.8    Kondo, T.9
  • 36
    • 0034655172 scopus 로고    scopus 로고
    • A synthetic inhibitor of Factor Xa, DX-9065a, reduces proliferation of vascular smooth muscle cells in vivo in rats
    • Kaiser B, Paintz M, Scholz O, Kunitada S, Fareed J: A synthetic inhibitor of Factor Xa, DX-9065a, reduces proliferation of vascular smooth muscle cells in vivo in rats. Thromb Res (2000) 98(2):175-185.
    • (2000) Thromb Res , vol.98 , Issue.2 , pp. 175-185
    • Kaiser, B.1    Paintz, M.2    Scholz, O.3    Kunitada, S.4    Fareed, J.5
  • 38
    • 0032864368 scopus 로고    scopus 로고
    • Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific Factor Xa inhibitor, in healthy male volunteers
    • note
    • Murayama N, Tanaka M, Kunitada S, Yamada H, Inoue T, Terada Y, Fujita M, Ikeda Y: Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific Factor Xa inhibitor, in healthy male volunteers. Clin Pharmacol Ther (1999) 66(3):258-264. This paper describes many of the human pharmacological characteristics of DX-9065a, a Factor Xa inhibitor that is at a relatively more advanced stage in clinical development.
    • (1999) Clin Pharmacol Ther , vol.66 , Issue.3 , pp. 258-264
    • Murayama, N.1    Tanaka, M.2    Kunitada, S.3    Yamada, H.4    Inoue, T.5    Terada, Y.6    Fujita, M.7    Ikeda, Y.8
  • 41
    • 0038146465 scopus 로고    scopus 로고
    • Joint Projects by Schering
    • 22 March
    • Schering AG: Joint Projects by Schering. Company World Wide Web Site 22 March (2001). http://www.schering.de
    • (2001)
    • Schering, A.G.1
  • 44
    • 25044470994 scopus 로고    scopus 로고
    • Antithrombotic effects of a selective Factor Xa (FXa) inhibitor KFA-1411, on the venous thrombosis model and less bleeding effects in rats
    • Hara K, Honma T, Nagano R, Matuzawa A, Akahane S, Kitazawa M: Antithrombotic effects of a selective Factor Xa (FXa) inhibitor KFA-1411, on the venous thrombosis model and less bleeding effects in rats. Jpn J Pharmacol (1999) 79(Suppl 1):P279.
    • (1999) Jpn J Pharmacol , vol.79 , Issue.SUPPL. 1
    • Hara, K.1    Honma, T.2    Nagano, R.3    Matuzawa, A.4    Akahane, S.5    Kitazawa, M.6
  • 47
    • 0031957619 scopus 로고    scopus 로고
    • Comparative studies of an orally-active Factor Xa inhibitor, YM-60828, with various antithrombotic agents in a rat model of arterial thrombosis
    • Kawasaki T, Sato K, Hirayama F, Koshoi H, Taniuchi Y, Matsumoto Y: Comparative studies of an orally-active Factor Xa inhibitor, YM-60828, with various antithrombotic agents in a rat model of arterial thrombosis. Thromb Haemost (1998) 79(4):859-864.
    • (1998) Thromb Haemost , vol.79 , Issue.4 , pp. 859-864
    • Kawasaki, T.1    Sato, K.2    Hirayama, F.3    Koshoi, H.4    Taniuchi, Y.5    Matsumoto, Y.6
  • 48
    • 0030952743 scopus 로고    scopus 로고
    • Biochemical and pharmacologic rationale for the development of a synthetic heparin pentasaccharide
    • note
    • Walenga JM, Jeske WP, Bara L, Samama MM, Fareed J: Biochemical and pharmacologic rationale for the development of a synthetic heparin pentasaccharide. Thromb Res (1997) 86(1):1-36. This paper describes many of the basic characteristics of fondaparinux sodium.
    • (1997) Thromb Res , vol.86 , Issue.1 , pp. 1-36
    • Walenga, J.M.1    Jeske, W.P.2    Bara, L.3    Samama, M.M.4    Fareed, J.5
  • 49
    • 0021061174 scopus 로고
    • Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-Factor Xa activity
    • Choay J, Petitou M, Lormeau JC, Sinay P, Casu B, Gatti G: Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-Factor Xa activity. Biochem Biophys Res Commun (1983) 116(2):492-499.
    • (1983) Biochem Biophys Res Commun , vol.116 , Issue.2 , pp. 492-499
    • Choay, J.1    Petitou, M.2    Lormeau, J.C.3    Sinay, P.4    Casu, B.5    Gatti, G.6
  • 50
    • 0002707929 scopus 로고
    • Total synthesis of a heparin pentasaccharide fragment having high affinity for antithrombin III
    • Sinay P, Jaquinet JE, Petitou M et al: Total synthesis of a heparin pentasaccharide fragment having high affinity for antithrombin III. Carbohydr Res (1984) 132(Suppl):C5-C9.
    • (1984) Carbohydr Res , vol.132 , Issue.SUPPL.
    • Sinay, P.1    Jaquinet, J.E.2    Petitou, M.3
  • 51
    • 0023049220 scopus 로고
    • Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide
    • Petitou M, Duchaussoy P, Lederman I, Choay J, Sinay P, Jacquinet JC, Torri G: Synthesis of heparin fragments. A chemical synthesis of the pentasaccharide O-(2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranosyl)-(1-4)-O-(β-D-glu copyranosyluronic acid)-(1-4)-O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-D-glucopyranosyl)-(1-4 )-O-(2-O-sulfo-α-L-idopyranosyluronic acid)-(1-4)-2-deoxy-2-sulfamido-6-O-sulfo-D-glucopyranose decasodium salt, a heparin fragment having high affinity for antithrombin III. Carbohydr Res (1986) 147(2):221-236.
    • (1986) Carbohydr Res , vol.147 , Issue.2 , pp. 221-236
    • Petitou, M.1    Duchaussoy, P.2    Lederman, I.3    Choay, J.4    Sinay, P.5    Jacquinet, J.C.6    Torri, G.7
  • 52
    • 0023214250 scopus 로고
    • Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges
    • Walenga JM, Petitou M, Lormeau JC, Samama M, Fareed J, Choay J: Antithrombotic activity of a synthetic heparin pentasaccharide in a rabbit stasis thrombosis model using different thrombogenic challenges. Thromb Res (1987) 46(2):187-198.
    • (1987) Thromb Res , vol.46 , Issue.2 , pp. 187-198
    • Walenga, J.M.1    Petitou, M.2    Lormeau, J.C.3    Samama, M.4    Fareed, J.5    Choay, J.6
  • 53
    • 0023923422 scopus 로고
    • The inhibition of the generation of thrombin and the antithrombotic effect of a pentasaccharide with sole anti-Factor Xa activity
    • Walenga JM, Bara L, Petitou M, Samama M, Fareed J, Choay J: The inhibition of the generation of thrombin and the antithrombotic effect of a pentasaccharide with sole anti-Factor Xa activity. Thromb Res (1988) 51(1):23-33.
    • (1988) Thromb Res , vol.51 , Issue.1 , pp. 23-33
    • Walenga, J.M.1    Bara, L.2    Petitou, M.3    Samama, M.4    Fareed, J.5    Choay6
  • 54
    • 0025262410 scopus 로고
    • Pharmacological profile of the chemically synthesized antithrombin III binding fragment of heparin (pentasaccharide) in rats
    • Hobbelen PM, Van Dinther TG, Vogel GM, Van Boeckel CA, Moelker HC, Meuleman DG: Pharmacological profile of the chemically synthesized antithrombin III binding fragment of heparin (pentasaccharide) in rats. Thromb Haemost (1990) 63(2):265-270.
    • (1990) Thromb Haemost , vol.63 , Issue.2 , pp. 265-270
    • Hobbelen, P.M.1    Van Dinther, T.G.2    Vogel, G.M.3    Van Boeckel, C.A.4    Moelker, H.C.5    Meuleman, D.G.6
  • 55
    • 0036195867 scopus 로고    scopus 로고
    • Fondaparinux: A synthetic heparin pentasaccharide as a new antithrombotic agent
    • note
    • Walenga JM, Jeske WP, Samama MM, Frapaise FX, Bick RL, Fareed J: Fondaparinux: A synthetic heparin pentasaccharide as a new antithrombotic agent. Expert Opin Investig Drugs (2002) 11(3):397-407. This paper describes many of the basic characteristics as well as the first clinical experiences of fondaparinux sodium including its solely anti-Factor Xa activity.
    • (2002) Expert Opin Investig Drugs , vol.11 , Issue.3 , pp. 397-407
    • Walenga, J.M.1    Jeske, W.P.2    Samama, M.M.3    Frapaise, F.X.4    Bick, R.L.5    Fareed, J.6
  • 56
    • 0027028822 scopus 로고
    • Chemical synthesis of heparin fragments and analogues
    • Petitou M, Van Boeckel CA: Chemical synthesis of heparin fragments and analogues. Fortschr Chem Org Naturst (1992) 60:143-210.
    • (1992) Fortschr Chem Org Naturst , vol.60 , pp. 143-210
    • Petitou, M.1    Van Boeckel, C.A.2
  • 58
    • 0038823170 scopus 로고
    • A new synthetic pentasaccharide with increased anti-Factor Xa activity: Possible role for anionic clusters in the interaction of heparin and antithrombin III
    • Petitou M, Lormeau JC, Choay J: A new synthetic pentasaccharide with increased anti-Factor Xa activity: Possible role for anionic clusters in the interaction of heparin and antithrombin III. Semin Thromb Res (1993) 19(Suppl 2):143-146.
    • (1993) Semin Thromb Res , vol.19 , Issue.SUPPL. 2 , pp. 143-146
    • Petitou, M.1    Lormeau, J.C.2    Choay, J.3
  • 60
    • 0025770037 scopus 로고
    • Antifactor Xa activity and antithrombotic activity in rats of structural analogues of the minimum antithrombin III binding sequence: Discovery of compounds with a longer duration of action than of the natural pentasaccharide
    • Meuleman DG, Hobbelen PM, Van Dinther TG, Vogel GM, Van Boeckel CA, Moelker HC: Antifactor Xa activity and antithrombotic activity in rats of structural analogues of the minimum antithrombin III binding sequence: Discovery of compounds with a longer duration of action than of the natural pentasaccharide. Semin Thromb Hemost (1991) 17(Suppl 1):112-117.
    • (1991) Semin Thromb Hemost , vol.17 , Issue.SUPPL. 1 , pp. 112-117
    • Meuleman, D.G.1    Hobbelen, P.M.2    Van Dinther, T.G.3    Vogel, G.M.4    Van Boeckel, C.A.5    Moelker, H.C.6
  • 61
    • 0028913873 scopus 로고
    • Synthetic analogues of the antithrombin III-binding pentasaccharide sequence of heparin. Prediction of in vivo residence times
    • Van Amsterdam RG, Vogel GM, Visser A, Kop WJ, Buiting MT, Meuleman DG: Synthetic analogues of the antithrombin III-binding pentasaccharide sequence of heparin. Prediction of in vivo residence times. Arterioscler Thromb Vasc Biol (1995) 15(4):495-503.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , Issue.4 , pp. 495-503
    • Van Amsterdam, R.G.1    Vogel, G.M.2    Visser, A.3    Kop, W.J.4    Buiting, M.T.5    Meuleman, D.G.6
  • 62
    • 0037808805 scopus 로고
    • AT III as a rate limiting factor for the measurement of pentasaccharide in laboratory assays
    • Walenga JM, Bara L, Hoppensteadt D, Choay J, Fareed J, Samama M: AT III as a rate limiting factor for the measurement of pentasaccharide in laboratory assays. Thromb Haemost (1991) 65(Suppl):1314.
    • (1991) Thromb Haemost , vol.65 , Issue.SUPPL. , pp. 1314
    • Walenga, J.M.1    Bara, L.2    Hoppensteadt, D.3    Choay, J.4    Fareed, J.5    Samama, M.6
  • 63
    • 0030035480 scopus 로고    scopus 로고
    • Antithrombin-mediated inhibition of Factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin
    • Lormeau JC, Hérault JP, Herbert JM: Antithrombin-mediated inhibition of Factor VIIa-tissue factor complex by the synthetic pentasaccharide representing the heparin binding site to antithrombin. Thromb Haemost (1996) 76(1):5-8.
    • (1996) Thromb Haemost , vol.76 , Issue.1 , pp. 5-8
    • Lormeau, J.C.1    Hérault, J.P.2    Herbert, J.M.3
  • 64
    • 0038485155 scopus 로고
    • The antithrombotic activity of synthetic pentasaccharides and fraxiparine is closely correlated with their respective ability to alter thromboplastin-triggered thrombin generation ex vivo
    • Dol F, Gaich C, Petitou M et al: The antithrombotic activity of synthetic pentasaccharides and fraxiparine is closely correlated with their respective ability to alter thromboplastin-triggered thrombin generation ex vivo. Thromb Haemost (1993) 69(Suppl):655.
    • (1993) Thromb Haemost , vol.69 , Issue.SUPPL. , pp. 655
    • Dol, F.1    Gaich, C.2    Petitou, M.3
  • 65
    • 0024339952 scopus 로고
    • The action of a synthetic pentasaccharide on thrombin generation in whole plasma
    • Béguin S, Choay J, Hemker HC: The action of a synthetic pentasaccharide on thrombin generation in whole plasma. Thromb Haemost (1989) 61(3):397-401.
    • (1989) Thromb Haemost , vol.61 , Issue.3 , pp. 397-401
    • Béguin, S.1    Choay, J.2    Hemker, H.C.3
  • 66
    • 0027476096 scopus 로고
    • Comparative inhibition of extrinsic and intrinsic thrombin generation by standard heparin, a low molecular weight heparin, and a synthetic ATIII-binding pentasaccharide
    • Lormeau JC, Hérault JP: Comparative inhibition of extrinsic and intrinsic thrombin generation by standard heparin, a low molecular weight heparin, and a synthetic ATIII-binding pentasaccharide. Thromb Haemost (1993) 69(2):152-156.
    • (1993) Thromb Haemost , vol.69 , Issue.2 , pp. 152-156
    • Lormeau, J.C.1    Hérault, J.P.2
  • 67
    • 0029563321 scopus 로고
    • The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of Factor Xa
    • Lormeau JC, Hérault JP: The effect of the synthetic pentasaccharide SR 90107/ORG 31540 on thrombin generation ex vivo is uniquely due to ATIII-mediated neutralization of Factor Xa. Thromb Haemost (1995) 74(6):1474-1477.
    • (1995) Thromb Haemost , vol.74 , Issue.6 , pp. 1474-1477
    • Lormeau, J.C.1    Hérault, J.P.2
  • 68
    • 0002787983 scopus 로고    scopus 로고
    • Relative heparin-induced thrombocytopenic potential of low molecular weight heparins and new antithrombotic agents
    • Walenga JM, Koza MJ, Lewis BE, Pifarré R: Relative heparin-induced thrombocytopenic potential of low molecular weight heparins and new antithrombotic agents. Clin Appl Thrombosis/Hemostasis (1996) 2(Suppl 1):S21-S27.
    • (1996) Clin Appl Thrombosis/Hemostasis , vol.2 , Issue.SUPPL. 1
    • Walenga, J.M.1    Koza, M.J.2    Lewis, B.E.3    Pifarré, R.4
  • 69
    • 0000417730 scopus 로고
    • Pharmacokinetic (PK) parameters of AT binding pentasaccharides in three animal species: Predictive value for humans
    • Crépon B, Donat F, Bârzu T, Hérault JP: Pharmacokinetic (PK) parameters of AT binding pentasaccharides in three animal species: Predictive value for humans. Thromb Haemost (1993) 69(Suppl):654.
    • (1993) Thromb Haemost , vol.69 , Issue.SUPPL. , pp. 654
    • Crépon, B.1    Donat, F.2    Bârzu, T.3    Hérault, J.P.4
  • 70
    • 0021864389 scopus 로고
    • Preliminary biochemical and pharmacologic studies on a chemically synthesized pentasaccharide
    • Walenga JM, Fareed J: Preliminary biochemical and pharmacologic studies on a chemically synthesized pentasaccharide. Semin Thromb Hemost (1985) 11(2):89-99.
    • (1985) Semin Thromb Hemost , vol.11 , Issue.2 , pp. 89-99
    • Walenga, J.M.1    Fareed, J.2
  • 71
    • 0029588344 scopus 로고
    • Pharmacokinetics and tolerance of the natural pentasaccharide (SR90107/Org31540) with high affinity to antithrombin III in man
    • Boneu B, Necciari J, Cariou R, Gabaig AM, Kieffer G, Dickinson J, Lamond G, Moelker H, Mant T et al: Pharmacokinetics and tolerance of the natural pentasaccharide (SR90107/Org31540) with high affinity to antithrombin III in man. Thromb Haemost (1995) 74(6):1468-1473.
    • (1995) Thromb Haemost , vol.74 , Issue.6 , pp. 1468-1473
    • Boneu, B.1    Necciari, J.2    Cariou, R.3    Gabaig, A.M.4    Kieffer, G.5    Dickinson, J.6    Lamond, G.7    Moelker, H.8    Mant, T.9
  • 72
    • 0035283092 scopus 로고    scopus 로고
    • A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement
    • note
    • Turpie AG, Gallus AS, Hoek JA, for the Pentasaccharide Investigators: A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. N Engl J Med (2001) 344(9):619-625. This paper describes an early clinical trial of fondaparinux sodium.
    • (2001) N Engl J Med , vol.344 , Issue.9 , pp. 619-625
    • Turpie, A.G.1    Gallus, A.S.2    Hoek, J.A.3
  • 73
    • 0003316277 scopus 로고    scopus 로고
    • Efficacy of the first synthetic Factor Xa inhibitor, pentasaccharide ORG31540/SR90107a, versus low molecular weight heparin (LMWH) in the prevention of venous thromboembolism (VTE) following elective hip replacement surgery: The PENTATHLON 2000 study
    • Abs OC48; note
    • Turpie AG: Efficacy of the first synthetic Factor Xa inhibitor, pentasaccharide ORG31540/SR90107a, versus low molecular weight heparin (LMWH) in the prevention of venous thromboembolism (VTE) following elective hip replacement surgery: The PENTATHLON 2000 study. Thromb Haemost (2001) (Suppl):Abs OC48 This paper describes an early clinical trial of fondaparinux sodium.
    • (2001) Thromb Haemost , Issue.SUPPL.
    • Turpie, A.G.1
  • 74
    • 0003316279 scopus 로고    scopus 로고
    • Efficacy of the first synthetic Factor Xa inhibitor, pentasaccharide ORG31540/SR90107a, versus low molecular weight heparin (LMWH) in the prevention of venous thromboembolism (VTE) following elective hip replacement surgery: The EPHESUS study
    • Abs OC45; note
    • Lassen MR: Efficacy of the first synthetic Factor Xa inhibitor, pentasaccharide ORG31540/SR90107a, versus low molecular weight heparin (LMWH) in the prevention of venous thromboembolism (VTE) following elective hip replacement surgery: The EPHESUS study. Thromb Haemost (2001) (Suppl):Abs OC45 This paper describes an early clinical trial of fondaparinux sodium.
    • (2001) Thromb Haemost , Issue.SUPPL.
    • Lassen, M.R.1
  • 75
    • 0035522302 scopus 로고    scopus 로고
    • Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery
    • note
    • Eriksson BI, Bauer KA, Lassen MR, Turpie AGG, for the Steering Committee of the Pentasaccharide in Hip-Fracture Surgery Study: Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip-fracture surgery. N Engl J Med (2001) 345(18):1298-1304. This paper describes an early
    • (2001) N Engl J Med , vol.345 , Issue.18 , pp. 1298-1304
    • Eriksson, B.I.1    Bauer, K.A.2    Lassen, M.R.3    Turpie, A.G.G.4
  • 76
    • 0035522304 scopus 로고    scopus 로고
    • Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery
    • note
    • Bauer KA, Eriksson BI, Lassen MR, Turpie AG, for the Steering Committee of the Pentasaccharide in Major Knee Surgery Study: Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery. N Engl J Med (2001) 345(18):1305-1310. This paper describes an early clinical trial of fondaparinux sodium.
    • (2001) N Engl J Med , vol.345 , Issue.18 , pp. 1305-1310
    • Bauer, K.A.1    Eriksson, B.I.2    Lassen, M.R.3    Turpie, A.G.4
  • 77
    • 0038146461 scopus 로고    scopus 로고
    • Fondaparinux (Arixtra) in comparison to (low molecular weight) heparin for the initial treatment of symptomatic deep venous thrombosis or pulmonary embolism - The Matisse Clinical Outcome studies
    • The Matisse Investigators: Fondaparinux (Arixtra) in comparison to (low molecular weight) heparin for the initial treatment of symptomatic deep venous thrombosis or pulmonary embolism - The Matisse Clinical Outcome studies. 44th Annual Meeting of the American Society of Hematology (2002):302.
    • (2002) 44th Annual Meeting of the American Society of Hematology , pp. 302
  • 78
    • 0038823169 scopus 로고    scopus 로고
    • Initial experience of a sulphated pentasaccharide, a pure Factor Xa inhibitor, in coronary angioplasty
    • Schiele FJ, Vuillemenot AR, Meneveau NF et al: Initial experience of a sulphated pentasaccharide, a pure Factor Xa inhibitor, in coronary angioplasty. Circulation (1996) 94(Suppl):I742.
    • (1996) Circulation , vol.94 , Issue.SUPPL.
    • Schiele, F.J.1    Vuillemenot, A.R.2    Meneveau, N.F.3
  • 79
    • 2642617786 scopus 로고    scopus 로고
    • Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide
    • note
    • Herbert JM, Herault JP, Bernat A, Van Amsterdam RG, Lormeau JC, Petitou M, Van Bouckel C, Hoffmann P, Meuleman DG: Biochemical and pharmacological properties of SANORG 34006, a potent and long-acting synthetic pentasaccharide. Blood (1998) 91(11):4197-4205. This paper describes many of the basic characteristics occurring as a result of a modification of fondaparinux sodium, and the different pharmacokinetic properties that make it more acceptable for medical purposes.
    • (1998) Blood , vol.91 , Issue.11 , pp. 4197-4205
    • Herbert, J.M.1    Herault, J.P.2    Bernat, A.3    Van Amsterdam, R.G.4    Lormeau, J.C.5    Petitou, M.6    Van Bouckel, C.7    Hoffmann, P.8    Meuleman, D.G.9
  • 80
    • 0012834737 scopus 로고    scopus 로고
    • A novel long-acting synthetic Factor Xa inhibitor (idraparinux sodium) to replace warfarin for secondary prevention in deep vein thrombosis. A phase II evaluation
    • Abs 301
    • Van Oers MHJ: A novel long-acting synthetic Factor Xa inhibitor (idraparinux sodium) to replace warfarin for secondary prevention in deep vein thrombosis. A phase II evaluation. Blood (2002) 100(11):Abs 301
    • (2002) Blood , vol.100 , Issue.11
    • Van Oers, M.H.J.1
  • 84
    • 25044464046 scopus 로고    scopus 로고
    • Failure of international normalized ratio in the monitoring of antithrombin and anti-Xa drugs
    • Tobu M, Hoppensteadt D, Jeske W, Walenga J, Fareed J: Failure of international normalized ratio in the monitoring of antithrombin and anti-Xa drugs. Ann Hematol (2003) 82(Suppl 1):S85.
    • (2003) Ann Hematol , vol.82 , Issue.SUPPL. 1
    • Tobu, M.1    Hoppensteadt, D.2    Jeske, W.3    Walenga, J.4    Fareed, J.5
  • 85
    • 0030586091 scopus 로고    scopus 로고
    • Antithrombotic actions of selective inhibitors of blood coagulation Factor Xa in rat models of thrombosis
    • Wong PC, Crain EJ Jr, Nguan O, Watson CA, Racanelli A: Antithrombotic actions of selective inhibitors of blood coagulation Factor Xa in rat models of thrombosis. Thromb Res (1996) 83(2):117-126.
    • (1996) Thromb Res , vol.83 , Issue.2 , pp. 117-126
    • Wong, P.C.1    Crain E.J. Jr2    Nguan, O.3    Watson, C.A.4    Racanelli, A.5
  • 86
    • 0029038740 scopus 로고
    • Design, synthesis and biological activities of orally active coagulation Factor Xa inhibitors
    • Nagahara T, Katakura S, Yokoyama Y et al: Design, synthesis and biological activities of orally active coagulation Factor Xa inhibitors. Eur J Med Chem (1995) 30(Suppl):140s-143s.
    • (1995) Eur J Med Chem , vol.30 , Issue.SUPPL.
    • Nagahara, T.1    Katakura, S.2    Yokoyama, Y.3
  • 87
    • 0030614665 scopus 로고    scopus 로고
    • The antithrombotic effect of synthetic low molecular weight human Factor Xa inhibitor, DX-9065a, on He-Ne laser-induced thrombosis in rat mesenteric microvessels
    • Yamashita T, Tsuji T, Matsuoka A, Giddings JC, Yamamoto J: The antithrombotic effect of synthetic low molecular weight human Factor Xa inhibitor, DX-9065a, on He-Ne laser-induced thrombosis in rat mesenteric microvessels. Thromb Res (1997) 85(1):45-51.
    • (1997) Thromb Res , vol.85 , Issue.1 , pp. 45-51
    • Yamashita, T.1    Tsuji, T.2    Matsuoka, A.3    Giddings, J.C.4    Yamamoto, J.5
  • 88
    • 0028114111 scopus 로고
    • Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of Factor Xa, against experimental disseminated intravascular coagulation in rats
    • Yamazaki M, Asakura H, Aoshima K, Saito M, Jokaji H, Uotani C, Kumabashiri I, Morishita E, Ikeda T, Matsuda T. Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of Factor Xa, against experimental disseminated intravascular coagulation in rats. Thromb Haemost (1994) 72(3):392-396.
    • (1994) Thromb Haemost , vol.72 , Issue.3 , pp. 392-396
    • Yamazaki, M.1    Asakura, H.2    Aoshima, K.3    Saito, M.4    Jokaji, H.5    Uotani, C.6    Kumabashiri, I.7    Morishita, E.8    Ikeda, T.9    Matsuda, T.10
  • 89
    • 0032729568 scopus 로고    scopus 로고
    • A specific inhibitor of Factor Xa, DX-9065a, exerts effective protection against experimental tumor induced disseminated intravascular coagulation in rats
    • Tanabe K, Terada Y, Shibutani T, Kunitada S, Kondo T: A specific inhibitor of Factor Xa, DX-9065a, exerts effective protection against experimental tumor induced disseminated intravascular coagulation in rats. Thromb Res (1999) 96(2):135-143.
    • (1999) Thromb Res , vol.96 , Issue.2 , pp. 135-143
    • Tanabe, K.1    Terada, Y.2    Shibutani, T.3    Kunitada, S.4    Kondo, T.5
  • 90
    • 0038823162 scopus 로고
    • Selective Factor Xa inhibitor, DX-9065a suppressed hypercoagulable state during haemodialysis in cynomologus monkeys
    • Hara T, Morishima Y, Kunitada S: Selective Factor Xa inhibitor, DX-9065a suppressed hypercoagulable state during haemodialysis in cynomologus monkeys. Thromb Haemost (1995) 73(Suppl);1311.
    • (1995) Thromb Haemost , vol.73 , Issue.SUPPL. , pp. 1311
    • Hara, T.1    Morishima, Y.2    Kunitada, S.3
  • 91
    • 4243923716 scopus 로고    scopus 로고
    • Anticoagulant and antithrombotic effects of the synthetic heparin pentasaccharide and the direct Factor Xa inhibitor DX-9065a after iv administration in rabbits
    • Kaiser B, Jeske W, Hoppensteadt D, Walenga JM, Fareed, J: Anticoagulant and antithrombotic effects of the synthetic heparin pentasaccharide and the direct Factor Xa inhibitor DX-9065a after iv administration in rabbits. Blood (1996) 88(Suppl 1):67b.
    • (1996) Blood , vol.88 , Issue.SUPPL. 1
    • Kaiser, B.1    Jeske, W.2    Hoppensteadt, D.3    Walenga, J.M.4    Fareed, J.5
  • 93
    • 0035146488 scopus 로고    scopus 로고
    • A novel synthetic inhibitor of Factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs
    • Abendschein DR, Baum PK, Verhallen P, Eisenberg PR, Sullivan ME, Light DR: A novel synthetic inhibitor of Factor Xa decreases early reocclusion and improves 24-h patency after coronary fibrinolysis in dogs. J Pharmacol Exp Ther (2001) 296(2):567-572.
    • (2001) J Pharmacol Exp Ther , vol.296 , Issue.2 , pp. 567-572
    • Abendschein, D.R.1    Baum, P.K.2    Verhallen, P.3    Eisenberg, P.R.4    Sullivan, M.E.5    Light, D.R.6
  • 94
    • 0038823163 scopus 로고    scopus 로고
    • Spring investor conference 2003
    • 13 March
    • Bayer AG: Spring investor conference 2003. Company Presentation 13 March (2003).
    • (2003) Company Presentation
    • Bayer, A.G.1
  • 96
    • 0038146457 scopus 로고    scopus 로고
    • Characterization of a novel Factor Xa inhibitor KFA-1829: Effects on coagulation systems, experimental thrombosis model and bleeding
    • Abs 21.2
    • Yuji H, Takashi K, Harunobu M, Keiko M, Naoyuki M, Satoshi A: Characterization of a novel Factor Xa inhibitor KFA-1829: Effects on coagulation systems, experimental thrombosis model and bleeding. World Congr Pharmacol (2002) 24: Abs 21.2
    • (2002) World Congr Pharmacol , vol.24
    • Yuji, H.1    Takashi, K.2    Harunobu, M.3    Keiko, M.4    Naoyuki, M.5    Satoshi, A.6
  • 98
    • 0038823160 scopus 로고    scopus 로고
    • Antithrombotic effects of DPC602, a potent and selective nonpeptide Factor Xa inhibitor, in rabbit models of thrombosis
    • Abs P1607
    • Wong PC, Crain EJ, Watson CA, Bai SA, Pruitt JR, Galemmo RA, Wexler RR, Knabb RM: Antithrombotic effects of DPC602, a potent and selective nonpeptide Factor Xa inhibitor, in rabbit models of thrombosis. Thromb Haemost (2001) (Suppl): Abs P1607
    • (2001) Thromb Haemost , Issue.SUPPL.
    • Wong, P.C.1    Crain, E.J.2    Watson, C.A.3    Bai, S.A.4    Pruitt, J.R.5    Galemmo, R.A.6    Wexler, R.R.7    Knabb, R.M.8
  • 101
    • 0024445042 scopus 로고
    • Antistasin, a leech-derived inhibitor of Factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site
    • Dunwiddie C, Thornberry NA, Bull HG, Sardana M, Friedman PA, Jacobs JW, Simpson E: Antistasin, a leech-derived inhibitor of Factor Xa. Kinetic analysis of enzyme inhibition and identification of the reactive site. J Biol Chem (1989) 264(28):16694-16699.
    • (1989) J Biol Chem , vol.264 , Issue.28 , pp. 16694-16699
    • Dunwiddie, C.1    Thornberry, N.A.2    Bull, H.G.3    Sardana, M.4    Friedman, P.A.5    Jacobs, J.W.6    Simpson, E.7
  • 102
    • 0001110594 scopus 로고
    • FXa inhibitor from the saliva of the leech Hirudo medicinalis
    • Rigbi M, Jackson CM, Atamna H et al: FXa inhibitor from the saliva of the leech Hirudo medicinalis. Thromb Haemost (1995) 73(Suppl):1306.
    • (1995) Thromb Haemost , vol.73 , Issue.SUPPL. , pp. 1306
    • Rigbi, M.1    Jackson, C.M.2    Atamna, H.3
  • 103
    • 0343996276 scopus 로고    scopus 로고
    • Persistent inhibition to 12 hours of mural platelet thrombosis after a single local infusion of tissue factor pathway inhibitor at the site of angioplasty
    • Wang Z, Hebert D, Kaplan AV, Creasy A, Galluppi GR: Persistent inhibition to 12 hours of mural platelet thrombosis after a single local infusion of tissue factor pathway inhibitor at the site of angioplasty. Circulation (1996) 94(8):1-268.
    • (1996) Circulation , vol.94 , Issue.8 , pp. 1-268
    • Wang, Z.1    Hebert, D.2    Kaplan, A.V.3    Creasy, A.4    Galluppi, G.R.5
  • 104
    • 0033995531 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor for cardiovascular disorders
    • Kaiser B, Hoppensteadt DA, Fareed J: Tissue factor pathway inhibitor for cardiovascular disorders. Exp Opin Emerging Drugs (2002) 5(1):73-88.
    • (2000) Exp Opin Emerging Drugs , vol.5 , Issue.1 , pp. 73-88
    • Kaiser, B.1    Hoppensteadt, D.A.2    Fareed, J.3
  • 105
    • 0029082791 scopus 로고
    • Tissue factor pathway inhibitor
    • Broze GJ Jr: Tissue factor pathway inhibitor. Thromb Haemost (1995) 74(1):90-93.
    • (1995) Thromb Haemost , vol.74 , Issue.1 , pp. 90-93
    • Broze G.J., Jr.1
  • 106
    • 0038823156 scopus 로고
    • Characterization of an orally available and highly specific synthetic Factor Xa inhibitor
    • Ostrem JA, Stringer S, Al-Obeidi F et al: Characterization of an orally available and highly specific synthetic Factor Xa inhibitor. Thromb Haemost (1995) 73(Suppl):1306.
    • (1995) Thromb Haemost , vol.73 , Issue.SUPPL. , pp. 1306
    • Ostrem, J.A.1    Stringer, S.2    Al-Obeidi, F.3
  • 108
    • 0026751368 scopus 로고
    • Reaction pathway for inhibition of blood coagulation Factor Xa by tick anticoagulant peptide
    • Jordan SP, Mao SS, Lewis SD, Shafer JA: Reaction pathway for inhibition of blood coagulation Factor Xa by tick anticoagulant peptide. Biochemistry (1992) 31(23):5374-5380.
    • (1992) Biochemistry , vol.31 , Issue.23 , pp. 5374-5380
    • Jordan, S.P.1    Mao, S.S.2    Lewis, S.D.3    Shafer, J.A.4
  • 109
    • 0025683260 scopus 로고
    • Tick anticoagulant peptide: Kinetic analysis of the recombinant inhibitor with blood coagulation Factor Xa
    • Jordan SP, Waxman L, Smith DE, Vlasuk GP: Tick anticoagulant peptide: Kinetic analysis of the recombinant inhibitor with blood coagulation Factor Xa. Biochemistry (1990) 29(50):11095-11100.
    • (1990) Biochemistry , vol.29 , Issue.50 , pp. 11095-11100
    • Jordan, S.P.1    Waxman, L.2    Smith, D.E.3    Vlasuk, G.P.4
  • 110
    • 0028287885 scopus 로고
    • Assembly of the prothrombinase complex enhances the inhibition of bovine Factor Xa by tick anticoagulant peptide
    • Krishnaswamy S, Vlasuk GP, Bergum PW: Assembly of the prothrombinase complex enhances the inhibition of bovine Factor Xa by tick anticoagulant peptide. Biochemistry (1994) 33(25):7897-7907.
    • (1994) Biochemistry , vol.33 , Issue.25 , pp. 7897-7907
    • Krishnaswamy, S.1    Vlasuk, G.P.2    Bergum, P.W.3
  • 111
    • 0027216868 scopus 로고
    • Structural and functional characterization of tick anticoagulant peptide (TAP): A potent and selective inhibitor of blood coagulation Factor Xa
    • Vlasuk GP: Structural and functional characterization of tick anticoagulant peptide (TAP): A potent and selective inhibitor of blood coagulation Factor Xa. Thromb Haemost (1993) 70(1):212-216.
    • (1993) Thromb Haemost , vol.70 , Issue.1 , pp. 212-216
    • Vlasuk, G.P.1
  • 112
    • 0025891319 scopus 로고
    • Comparison of the in vivo anticoagulant properties of standard heparin and the highly selective Factor Xa inhibitors antistasin and tick anticoagulant peptide (TAP) in a rabbit model of venous thrombosis
    • Vlasuk GP, Ramjit D, Fujita T, Dunwiddie CT, Nutt EM, Smith DE, Shebuski RJ: Comparison of the in vivo anticoagulant properties of standard heparin and the highly selective Factor Xa inhibitors antistasin and tick anticoagulant peptide (TAP) in a rabbit model of venous thrombosis. Thromb Haemost (1991) 65(3):257-262.
    • (1991) Thromb Haemost , vol.65 , Issue.3 , pp. 257-262
    • Vlasuk, G.P.1    Ramjit, D.2    Fujita, T.3    Dunwiddie, C.T.4    Nutt, E.M.5    Smith, D.E.6    Shebuski, R.J.7
  • 113
    • 0027295989 scopus 로고
    • Antithrombotic activity of recombinant tick anticoagulant peptide and heparin in a rabbit model of venous thrombosis
    • Fioravanti C, Burkholder D, Francis B, Siegl PK, Gibson RE: Antithrombotic activity of recombinant tick anticoagulant peptide and heparin in a rabbit model of venous thrombosis. Thromb Res (1993) 71(4):317-324.
    • (1993) Thromb Res , vol.71 , Issue.4 , pp. 317-324
    • Fioravanti, C.1    Burkholder, D.2    Francis, B.3    Siegl, P.K.4    Gibson, R.E.5
  • 114
    • 0029153603 scopus 로고
    • Primary prevention of coronary arterial thrombosis with the Factor Xa inhibitor rTAP in a canine electrolytic injury model
    • Lynch JJ Jr, Sitko GR, Lehman ED, Vlasuk GP: Primary prevention of coronary arterial thrombosis with the Factor Xa inhibitor rTAP in a canine electrolytic injury model. Thromb Haemost (1995) 74(2):640-645.
    • (1995) Thromb Haemost , vol.74 , Issue.2 , pp. 640-645
    • Lynch J.J., Jr.1    Sitko, G.R.2    Lehman, E.D.3    Vlasuk, G.P.4
  • 115
    • 0026059199 scopus 로고
    • Antithrombotic efficacy of recombinant tick anticoagulant peptide. A potent inhibitor of coagulation Factor Xa in a primate model of arterial thrombosis
    • Schaffer LW, Davidson JT, Vlasuk GP, Siegl PK: Antithrombotic efficacy of recombinant tick anticoagulant peptide. A potent inhibitor of coagulation Factor Xa in a primate model of arterial thrombosis. Circulation (1991) 84(4):1741-1748.
    • (1991) Circulation , vol.84 , Issue.4 , pp. 1741-1748
    • Schaffer, L.W.1    Davidson, J.T.2    Vlasuk, G.P.3    Siegl, P.K.4
  • 116
    • 0029610423 scopus 로고
    • Effect of selective Factor Xa inhibition on arterial thrombus formation triggered by tissue factor/Factor VIIa or collagen in an ex vivo model of shear-dependent human thrombogenesis
    • Ørvim U, Barstad RM, Vlasuk GP, Sakariassen KS: Effect of selective Factor Xa inhibition on arterial thrombus formation triggered by tissue factor/Factor VIIa or collagen in an ex vivo model of shear-dependent human thrombogenesis. Arterioscler Thromb Vasc Biol (1995) 15(12):2188-2194.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , Issue.12 , pp. 2188-2194
    • Ørvim, U.1    Barstad, R.M.2    Vlasuk, G.P.3    Sakariassen, K.S.4
  • 117
    • 0027161780 scopus 로고
    • Enhancement of recombinant tissue plasminogen activator-induced reperfusion by recombinant tick anticoagulant peptide, a selective Factor Xa inhibitor, in a canine model of femoral arterial thrombolysis
    • Mellott MJ, Stranieri MT, Sitko GR, Stabilito II, Lynch J, Vlasuk GP: Enhancement of recombinant tissue plasminogen activator-induced reperfusion by recombinant tick anticoagulant peptide, a selective Factor Xa inhibitor, in a canine model of femoral arterial thrombolysis. Fibrinolysis (1993) 7:195-202.
    • (1993) Fibrinolysis , vol.7 , pp. 195-202
    • Mellott, M.J.1    Stranieri, M.T.2    Sitko, G.R.3    Stabilito, I.I.4    Lynch, J.5    Vlasuk, G.P.6
  • 118
    • 0026558347 scopus 로고
    • Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective Factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis
    • Sitko GR, Ramjit DR, Stabilito II, Lehman D, Lynch JJ, Vlasuk GP: Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with the selective Factor Xa inhibitor, tick anticoagulant peptide. Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis. Circulation (1992) 85(2):805-815.
    • (1992) Circulation , vol.85 , Issue.2 , pp. 805-815
    • Sitko, G.R.1    Ramjit, D.R.2    Stabilito, I.I.3    Lehman, D.4    Lynch, J.J.5    Vlasuk, G.P.6
  • 119
    • 0030466724 scopus 로고    scopus 로고
    • Selective inhibition of Factor Xa is more efficient than Factor VIIa-tissue factor complex blockade at facilitating coronary thrombolysis in the canine model
    • Lefkovitz J, Malycky JL, Rao JS, Hart CE, Plow EF, Topol EJ, Nicolini FA: Selective inhibition of Factor Xa is more efficient than Factor VIIa-tissue factor complex blockade at facilitating coronary thrombolysis in the canine model. J Am Coll Cardiol (1996) 28(7):1858-1865.
    • (1996) J Am Coll Cardiol , vol.28 , Issue.7 , pp. 1858-1865
    • Lefkovitz, J.1    Malycky, J.L.2    Rao, J.S.3    Hart, C.E.4    Plow, E.F.5    Topol, E.J.6    Nicolini, F.A.7
  • 120
    • 0000153530 scopus 로고
    • Anticoagulant repertoire of hematophagous nematodes
    • Vlasuk GP, Bergum PW, Brunck TK et al. Anticoagulant repertoire of hematophagous nematodes. Thromb Haemost (1995) 73(Suppl):1305.
    • (1995) Thromb Haemost , vol.73 , Issue.SUPPL. , pp. 1305
    • Vlasuk, G.P.1    Bergum, P.W.2    Brunck, T.K.3


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