Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 2127-2146

  Kochanny, Monica J ^a   Adler, Marc ^a   Ewing, Janice ^a   Griedel, Brian D ^a   Ho, Elena ^a   Karanjawala, Rushad ^a   Lee, Wheeseong ^a   Lentz, Dao ^a   Liang, Amy M ^a   Morrissey, Michael M ^a   Phillips, Gary B ^a   Post, Joseph ^a   Sacchi, Karna L ^a   Sakata, Steven T ^a   Subramanyam, Babu ^a   Vergona, Ron ^a   Walters, Janette ^a   White, Kathy A ^a   Whitlow, Marc ^a   Ye, Bin ^a   Zhao, Zuchun ^a   Shaw, Kenneth J ^a   more..

^a BAYER AG   (Germany)

Author keywords

Anticoagulant; Factor Xa inhibitor; Non amidine; Thrombosis

Indexed keywords

2 AMINOBENZAMIDE; 3 CHLORO N [4 CHLORO 2 [[(4 CHLOROPHENYL)AMINO]CARBONYL]PHENYL] 4 [(2,3 DIHYDROXYPROPOXY)METHYL] 2 THIOPHENECARBOXAMIDE; 3 CHLORO N [4 CHLORO 2 [[(4 CHLOROPHENYL)AMINO]CARBONYL]PHENYL] 4 [(4 METHYL 1 PIPERAZINYL)METHYL] 2 THIOPHENECARBOXAMIDE; 3 CHLORO N [4 CHLORO 2 [[(4 CHLOROPHENYL)AMINO]CARBONYL]PHENYL] 4 [[(2,3 DIHYDROXYPROPYL)METHYLAMINO]METHYL] 2 THIOPHENECARBOXAMIDE TRIFLUOROACETIC ACID SALT; 3 CHLORO N [4 CHLORO 2 [[(4 CHLOROPHENYL)AMINO]CARBONYL]PHENYL] 4 [[[2 (DIMETHYLAMINO)ETHYL]METHYLAMINO]METHYL] 2 THIOPHENECARBOXAMIDE; 3 CHLORO N [4 CHLORO 2 [[(4 CHLOROPHENYL)AMINO]CARBONYL]PHENYL] 4 [[[2 (DIMETHYLAMINO)ETHYL]THIO]METHYL] 2 THIOPHENECARBOXAMIDE; BLOOD CLOTTING FACTOR 10A INHIBITOR; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; CRYSTAL STRUCTURE; DOG; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHILICITY; MALE; NONHUMAN; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMIDES; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DOGS; FACTOR XA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, MOLECULAR; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

CANIS FAMILIARIS;

EID: 33846617308     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.019     Document Type: Article

References (52)

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