Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand

Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2003, Pages 681-684

  Choi Sledeski, Yong Mi ^a   Kearney, Robert ^a   Poli, Gregory ^a   Pauls, Henry ^a   Gardner, Charles ^a   Gong, Yong ^a   Becker, Michael ^a   Davis, Roderick ^a   Spada, Alfred ^a   Liang, Guyan ^a   Chu, Valeria ^a   Brown, Karen ^a   Collussi, Dennis ^a   Leadley Jr , Robert ^a   Rebello, Sam ^a   Moxey, Phillip ^a   Morgan, Suzanne ^a   Bentley, Ross ^a   Kasiewski, Charles ^a   Maignan, Sebastien ^a   Guilloteau, Jean Pierre ^a   Mikol, Vincent ^a   more..

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BENZAMIDE DERIVATIVE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING INHIBITOR; INDOLE DERIVATIVE; METHYLAZAINDOLE; PIPERAZINE DERIVATIVE; RPR 209685; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOG; DOSE RESPONSE; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; ENZYME ANALYSIS; INHIBITION KINETICS; LIGAND BINDING; LIVER MICROSOME; NONHUMAN; RAT; REACTION OPTIMIZATION; STRUCTURE ACTIVITY RELATION; TABLET FORMULATION; THROMBOSIS; X RAY ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; AZA COMPOUNDS; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DOGS; FACTOR XA; INDOLES; LIGANDS; MICROSOMES, LIVER; PIPERAZINES; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0037468474     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020384z     Document Type: Article

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