Removal of the 20-methyl group from 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD) selectively eliminates bone calcium mobilization activity

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7658-7669

  Barycki, Rafal ^a   Sicinski, Rafal R ^a,b   Plum, Lori A ^a   Grzywacz, Pawel ^a   Clagett Dame, Margaret ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

19 Norvitamin D; Calcemic activity; Vitamin D analogs; Vitamin D receptor

Indexed keywords

2 METHYLENE 18 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; 2 METHYLENE 18,21 DINOR 1ALPHA,25 DIHYDROXYVITAMIN D3; 2 METHYLENE 19 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; 2 METHYLENE 21 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; CALCITRIOL DERIVATIVE; CALCIUM; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM BONE LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; HORNER REACTION; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BONE AND BONES; CALCITRIOL; CALCIUM; CELL LINE; HL-60 CELLS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 71749103461     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.047     Document Type: Article

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