Methyl substitution of the 25-hydroxy group on 2-methylene-19-nor-1α,25-dihydroxyvitamin D3 (2MD) reduces potency but allows bone selectivity

Archives of Biochemistry and Biophysics

Volumn 460, Issue 2, 2007, Pages 274-284

  Grzywacz, Pawel ^a   Plum, Lori A ^a   Sicinski, Rafal R ^a,b   Clagett Dame, Margaret ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

19 Norvitamin D; Calcemic activity; HL 60 differentiation; Transcription activity; VDR binding; Vitamin D analogs

Indexed keywords

1ALPHA HYDROXY 25 METHYL 2 METHYLENE 19 NORVITAMIN D3; 2 METHYLENE 19 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; CALCITRIOL DERIVATIVE; CALCIUM; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BONE; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM MOBILIZATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CHEMICAL STRUCTURE; FEMALE; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; MOUSE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE DRUG DOSE; SYNTHESIS;

ANIMALS; BONE AND BONES; BONE RESORPTION; CALCITRIOL; DRUG SYNERGISM; FEMALE; HL-60 CELLS; HUMANS; MICE; ORGAN SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMINS;

EID: 34247124823     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2006.09.028     Document Type: Article

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