Adenosine A2A receptor deficiency reduces striatal glutamate outflow and attenuates brain injury induced by transient focal cerebral ischemia in mice

Brain Research

Volumn 1297, Issue , 2009, Pages 185-193

  Gui, Li ^a   Duan, Wei ^a   Tian, Hong ^a   Li, Chuanming ^a   Zhu, Jie ^a   Chen, Jiang Fan ^b   Zheng, Jian ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine A2A receptor; Cerebral ischemia; Excitotoxicity; Glutamate; Mouse

Indexed keywords

ADENOSINE A2A RECEPTOR; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN PERFUSION; CONTROLLED STUDY; CORPUS STRIATUM; GENE INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MICRODIALYSIS; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TRANSIENT ISCHEMIC ATTACK;

ADENOSINE; ANIMALS; BRAIN CHEMISTRY; BRAIN INFARCTION; BRAIN ISCHEMIA; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOWN-REGULATION; EXTRACELLULAR FLUID; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GLUTAMIC ACID; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRODIALYSIS; RECEPTOR, ADENOSINE A2A; UP-REGULATION;

ANIMALIA; MUS;

EID: 71749094698     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.08.050     Document Type: Article

References (43)

1. Amemiya S., Kamiya T., Nito C., Inaba T., Kato K., Ueda M., Shimazaki K., and Katayama Y. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats. Eur. J. Pharmacol. 516 (2005) 125-130
2. Bona E., Aden U., Gilland E., Fredholm B.B., and Hagberg H. Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists. Neuropharmacology 36 (1997) 1327-1338
3. Boyle D.L., Sajjadi F.G., and Firestein G.S. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum. 39 (1996) 923-930
4. Cao C.X., Yang Q.W., Lv F.L., Cui J., Fu H.B., and Wang J.Z. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem. Biophys. Res. Commun. 353 (2007) 509-514
5. Chen J.F., Huang Z., Ma J., Zhu J., Moratalla R., Standaert D., Moskowitz M.A., Fink J.S., and Schwarzschild M.A. A(2A) adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice. J. Neurosci. 19 (1999) 9192-9200
6. Chen J.F., Sonsalla P.K., Pedata F., Melani A., Domenici M.R., Popoli P., Geiger J., Lopes L.V., and de Mendonca A. Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation. Prog. Neurobiol. 83 (2007) 310-331
7. Coney A.M., and Marshall J.M. Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. J. Physiol. 509 Pt. 2 (1998) 507-518
8. Corsi C., Melani A., Bianchi L., Pepeu G., and Pedata F. Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats. Neuroreport 10 (1999) 687-691
9. Corsi C., Melani A., Bianchi L., and Pedata F. Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats. Neuroreport 11 (2000) 2591-2595
10. Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
11. Dixon A.K., Widdowson L., and Richardson P.J. Desensitisation of the adenosine A1 receptor by the A2A receptor in the rat striatum. J. Neurochem. 69 (1997) 315-321
12. Fredholm B.B., Arslan G., HAlldner L., Arslan G., and Halldner L. Adenosine receptor signaling in vitro and in vivo. Drug Dev. Res. 52 (2001) 274-282
13. Gao Y., and Phillis J.W. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 55 (1994) PL61-5
14. Hazell A.S. Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem. Int. 50 (2007) 941-953
15. Huang Q.Y., Wei C., Yu L., Coelho J.E., Shen H.Y., Kalda A., Linden J., and Chen J.F. Adenosine A2A receptors in bone marrow-derived cells but not in forebrain neurons are important contributors to 3-nitropropionic acid-induced striatal damage as revealed by cell-type-selective inactivation. J. Neurosci. 26 (2006) 11371-11378
16. Huang Z., Huang P.L., Panahian N., Dalkara T., Fishman M.C., and Moskowitz M.A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265 (1994) 1883-1885
17. Kogure K., Tanaka J., and Araki T. The mechanism of ischemia-induced brain cell injury. The membrane theory. Neurochem. Pathol. 9 (1988) 145-170
18. Li X., Blizzard K.K., Zeng Z., DeVries A.C., Hurn P.D., and McCullough L.D. Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender. Exp. Neurol. 187 (2004) 94-104
19. Lo E.H., Pierce A.R., Matsumoto K., Kano T., Evans C.J., and Newcomb R. Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion. Neuroscience 83 (1998) 449-458
20. Manita S., Kawamura Y., Sato K., Inoue M., Kudo Y., and Miyakawa H. Adenosine A(1)-receptor-mediated tonic inhibition of glutamate release at rat hippocampal CA3-CA1 synapses is primarily due to inhibition of N-type Ca(2+) channels. Eur. J. Pharmacol. 499 (2004) 265-274
21. Marchi M., Raiteri L., Risso F., Vallarino A., Bonfanti A., Monopoli A., Ongini E., and Raiteri M. Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes. Br. J. Pharmacol. 136 (2002) 434-440
22. Marcoli M., Raiteri L., Bonfanti A., Monopoli A., Ongini E., Raiteri M., and Maura G. Sensitivity to selective adenosine A1 and A2A receptor antagonists of the release of glutamate induced by ischemia in rat cerebrocortical slices. Neuropharmacology 45 (2003) 201-210
23. Matsumoto K., Lo E.H., Pierce A.R., Halpern E.F., and Newcomb R. Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16 (1996) 114-124
24. Melani A., Pantoni L., Bordoni F., Gianfriddo M., Bianchi L., Vannucchi M.G., Bertorelli R., Monopoli A., and Pedata F. The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat. Brain Res. 959 (2003) 243-250
25. Melani A., Gianfriddo M., Vannucchi M.G., Cipriani S., Baraldi P.G., Giovannini M.G., and Pedata F. The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia. Brain Res. 1073-1074 (2006) 470-480
26. Monopoli A., Lozza G., Forlani A., Mattavelli A., and Ongini E. Blockade of adenosine A2A receptors by SCH 58261 results in neuroprotective effects in cerebral ischaemia in rats. Neuroreport 9 (1998) 3955-3959
27. Nishizaki T., Nagai K., Nomura T., Tada H., Kanno T., Tozaki H., Li X.X., Kondoh T., Kodama N., Takahashi E., Sakai N., Tanaka K., and Saito N. A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors. Glia 39 (2002) 133-147
28. Nishizaki T. ATP- and adenosine-mediated signaling in the central nervous system: adenosine stimulates glutamate release from astrocytes via A2a adenosine receptors. J. Pharmacol. Sci. 94 (2004) 100-102
29. O'Regan M.H., Simpson R.E., Perkins L.M., and Phillis J.W. The selective A2 adenosine receptor agonist CGS 21680 enhances excitatory transmitter amino acid release from the ischemic rat cerebral cortex. Neurosci. Lett. 138 (1992) 169-172
30. Paxinos G.A.F., and K.B.J. The Mouse Brain in Stereotaxic Coordinates. 2nd ed. (2001), Academic Press, New York. 0-12-547637-X
31. Pedata F., Corsi C., Melani A., Bordoni F., and Latini S. Adenosine extracellular brain concentrations and role of A2A receptors in ischemia. Ann. N.Y. Acad. Sci. 939 (2001) 74-84
32. Pedata F., Gianfriddo M., Turchi D., and Melani A. The protective effect of adenosine A2A receptor antagonism in cerebral ischemia. Neurol. Res. 27 (2005) 169-174
33. Pellegrini-Giampietro D.E., Cherici G., Alesiani M., Carla V., and Moroni F. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage. J. Neurosci. 10 (1990) 1035-1041
34. Phillis J.W. Adenosine in the control of the cerebral circulation. Cerebrovasc. Brain Metab. Rev. 1 (1989) 26-54
35. Phillis J.W. The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil. Brain Res. 705 (1995) 79-84
36. Popoli P., Betto P., Reggio R., and Ricciarello G. Adenosine A2A receptor stimulation enhances striatal extracellular glutamate levels in rats. Eur. J. Pharmacol. 287 (1995) 215-217
37. Rothman S.M. Synaptic activity mediates death of hypoxic neurons. Science 220 (1983) 536-537
38. Sandoli D., Chiu P.J., Chintala M., Dionisotti S., and Ongini E. In vivo and ex vivo effects of adenosine A1 and A2 receptor agonists on platelet aggregation in the rabbit. Eur. J. Pharmacol. 259 (1994) 43-49
39. Simpson R.E., O'Regan M.H., Perkins L.M., and Phillis J.W. Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: effects of adenosine receptor agonists and antagonists. J. Neurochem. 58 (1992) 1683-1690
40. Traystman R.J., Kirsch J.R., and Koehler R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J. Appl. Physiol. 71 (1991) 1185-1195
41. Von Lubitz D.K., Lin R.C., and Jacobson K.A. Cerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist. Eur. J. Pharmacol. 287 (1995) 295-302
42. Yu L., Huang Z., Mariani J., Wang Y., Moskowitz M., and Chen J.F. Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury. Nat. Med. 10 (2004) 1081-1087
43. Zhao G., and Flavin M.P. Differential sensitivity of rat hippocampal and cortical astrocytes to oxygen-glucose deprivation injury. Neurosci. Lett. 285 (2000) 177-180