The benzoxathiolone LYR-71 down-regulates interferon-γ-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages

British Journal of Pharmacology

Volumn 158, Issue 8, 2009, Pages 1971-1981

  Chung, E Y ^a   Kim, B H ^a   Lee, I J ^a   Roh, E ^a   Oh, S J ^a   Kwak, J A ^a   Lee, Y R ^b   Ahn, B ^a   Nam, S Y ^a   Han, S B ^a   Kim, Y ^a  

^a Chungbuk National University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

Anti inflammatory action; Benzoxathiolone derivative; Chemokine; IFN ; Janus kinase; Macrophages; Nitric oxide; STAT 1

Indexed keywords

6 METHYL 2 PROPYLIMINO 6,7 DIHYDRO 5H BENZO[ 1,3 ]OXATHIOL 4 ONE; BENZOXAZOLE DERIVATIVE; CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE 2; LYR 71; NITRIC OXIDE; PROTEIN TYROSINE PHOSPHATASE; STAT1 PROTEIN; THIOL DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW; CELL LINE; CELL STIMULATION; CHEMICAL REACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BONE MARROW; CELL LINE; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMINES; INFLAMMATION; INTERFERON-GAMMA; MACROPHAGES; MALE; MICE; MICE, INBRED C3H; NITRIC OXIDE; PHOSPHORYLATION; STAT1 TRANSCRIPTION FACTOR; TYROSINE;

EID: 71649109062     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00496.x     Document Type: Article

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