Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 23, 2009, Pages 8040-8047

  Ortín, Irene ^a   González, Juan Francisco ^a   Cuesta, Elena de la ^a   Manguan García, Cristina ^b,c   Perona, Rosario ^b,c   Avendaño, Carmen ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Antitumor agents; Cyanation; Cytotoxicity mechanisms; Iminium ions; Tetrahydroisoquinolines

Indexed keywords

2 ISOPROPYLOXYCARBONYL 7,8,10 TRIMETHOXY 9 METHYL 6 (1 NAPHTHOYLOXYMETHYL) 1,2,3,4,11,11A HEXAHYDRO 6H PYRAZINO[1,2 B]ISOQUINOLIN 4 CARBONITRILE; 6 CINNAMOYLMETHYL 2 ISOPROPYLOXYCARBONYL 7,8,10 TRIMETHOXY 9 METHYL 1,2,3,4,11,11A HEXAHYDRO 6H PYRAZINO[1,2 B]ISOQUINOLIN 4 CARBONITRILE; 6 HYDROXYMETHYL 2 ISOPROPYLOXYCARBONYL 7,8,10 TRIMETHOXY 9 METHYL 1,2,3,4,11,11A HEXAHYDRO 6H PYRAZINO[1,2 B]ISOQUINOLIN 4 CARBONITRILE; CISPLATIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; ISOQUINOLINE DERIVATIVE; PROTEIN; PROTEIN WEE1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CELL CYCLE PROTEINS; CELL SURVIVAL; G2 PHASE; HT29 CELLS; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; PYRAZINES; SIGNAL TRANSDUCTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71649094970     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.007     Document Type: Article

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