Presence of the neuropeptide Y1 receptor in tenocytes and blood vessel walls in the human Achilles tendon

British Journal of Sports Medicine

Volumn 43, Issue 14, 2009, Pages 1136-1142

  Bjur, D ^a   Alfredson, H ^a   Forsgren, S ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR;

ACHILLES TENDINITIS; ACHILLES TENDON; ADULT; ANGIOGENESIS; ARTICLE; BLOOD VESSEL WALL; CELL PROLIFERATION; CHRONIC PAIN; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE;

ACHILLES TENDON; ADULT; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; RECEPTORS, NEUROPEPTIDE Y; TENDINOPATHY; YOUNG ADULT;

EID: 71649090299     PISSN: 03063674     EISSN: 14730480     Source Type: Journal    
DOI: 10.1136/bjsm.2008.055780     Document Type: Article

References (45)

1. Alfredson H. The chronic painful Achilles and patellar tendon: research on basic biology and treatment. Scand J Med Sci Sports 2005;15:252-259 (Pubitemid 41032389)
2. Tatemoto K. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci U S A 1982;79:5485-5489
3. Lundberg JM, Terenius L, Hökfelt T, et al. Neuropeptide Y-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 1982;116:447-480 (Pubitemid 13168152)
4. Ekblad E, Edvinsson L, Wahlestedt C, et al. Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers. Regulat Pept 1984;8:225-235 (Pubitemid 14109276)
5. Forsgren S. Neuropeptide Y-like immunoreactivity in relation to the distribution of sympathetic nerve fibers in the heart conduction system. J Mol Cell Cardiol 1989;21:279-290 (Pubitemid 19151696)
6. Leblanc GG, Trimmer BA, Landis SC. Neuropeptide Y-like immunoreactivity in rat cranial parasympathetic neurons: coexistence with vasoactive intestinal peptide and choline acetyltransferase. Proc Natl Acad Sci U S A 1987;84:3511-3515
7. Domeij S, Dahlqvist Å, Forsgren S. Studies on colocalization of neuropeptide Y, vasoactive intestinal polypeptide, catecholamine-synthesizing enzymes and acetylcholinesterase in the larynx of the rat. Cell Tissue Res 1991;263:495-505.
8. Lerch M, Kamimori H, Folkers G, et al. Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding. Biochemistry 2005;44:9255-9264 (Pubitemid 40943240)
9. Lindner D, Stichel J, Beck-Sickinger AG. Molecular recognition of the NPY hormone family by their receptors. Nutrition 2008;24:907-917
10. Grundemar L, Hakanson R. Multiple neuropeptide Y receptors are involved in cardiovascular regulation. Peripheral and central mechanisms. Gen Pharmacol 1993;24:785-796
11. Linder L, Lautenschlager BM, Haefeli W. Subconstrictor doses of neuropeptide Y potentiate alpha 1-adrenergic vasoconstriction in vivo. Hypertension 1996;28:483-487 (Pubitemid 26296055)
12. Abe K, Tilan JU, Zukowska Z. NPY and NPY receptors in vascular remodeling. Curr Top Med Chem 2007;7:1704-1709
13. Doyle KL, Karl T, Hort Y, et al. Y1 receptors are critical for the proliferation of adult mouse precursor cells in the olfactory neuroepithelium. J Neurochem2008;105:641-652
14. Pons J, Kitlinska J, Jacques D, et al. Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. Can J Physiol Pharmacol 2008;86:438-448 (Pubitemid 351948683)
15. Movin T, Gad A, Reinholt FP, et al. Tendon pathology in long-standing achillodynia. Biopsy findings in 40 patients. Acta Orthop Scand 1997;68:170-175
16. Cook JL, Feller JA, Bonar SF, et al. Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. J Orthop Res 2004;22:334-338
17. Khan KM, Cook JL, Bonar F, et al. Histopathology of common tendinopathies. Update and implications for clinical management. Sports Med 1999;27:393-408.
18. Bjur D, Alfredson H, Forsgren S. The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation. Cell Tissue Res 2005;320:201-206 (Pubitemid 40543774)
19. Alfredson H, Ohberg L, Forsgren S. Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections. Knee Surg Sports Traumatol Arthrosc 2003;11:334-338 (Pubitemid 38251124)
20. Pedrazzini T, Pralong F, Grouzmann E. Neuropeptide Y: the universal soldier. Cell Mol Life Sci 2003;60:350-377
21. Pons J, Lee EW, Li L, et al. Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases. Curr Opin Investig Drugs 2004;5:957-962
22. Körner M, Waser B, Reubi JC. High expression of neuropeptide Y1 receptors in Ewing sarcoma tumors. Clin Cancer Res 2008;14:5043-5049
23. Körner M, Reubi JC. NPY receptors in human cancer: a review of current knowledge. Peptides 2007;28:419-425 (Pubitemid 46176252)
24. Bjur D, Danielson P, Alfredson H, et al. Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy). Cell Tissue Res 2008;331:385-400.
25. Bjur D, Danielson P, Alfredson H, et al. Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon. Histol Histopathol 2008;23:197-208.
26. Forsgren S, Danielson P, Alfredson H. Vascular NK-1 receptor occurrence in normal and chronic painful Achilles and patellar tendons: studies on chemically unfixed as well as fixed specimens. Regulat Pept 2005;126:173-181 (Pubitemid 40128182)
27. Andersson G, Danielson P, Alfredson H, et al. Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon. Regulat Pept 2008;150:81-87
28. Hansson M, Forsgren S. Immunoreactive atrial and brain natriuretic peptides are co-localized in Purkinje fibres but not in the innervation of the bovine heart conduction system. Histochem J 1995;27:222-230
29. Ackermann PW, Li J, Finn A, et al. Autonomic innervation of tendons, ligaments and joint capsules. A morphologic and quantitative study in the rat. J Orthop Res 2001;19:372-378 (Pubitemid 32472005)
30. Andersson G, Danielson P, Alfredson H, et al. Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis. Knee Surg Sports Traumatol Arthrosc 2007;15:1272-1279
31. Pellieux C, Sauthier T, Domenighetti A, et al. Neuropeptide Y (NPY) potentiates phenylepinephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors. Proc Natl Acad Sci U S A 2000;97:1595-1600 (Pubitemid 30118487)
32. Uddman R, Möller S, Nilsson T, et al. Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues. Peptides 2002;23:927-934
33. Danielson P, Andersson G, Alfredson H, et al. Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients. Knee Surg Sports Traumatol Arthrosc 2008;16:621-626
34. Hansel DE, Eipper BA, Ronnett GV. Neuropeptide Y functions as a neuroproliferative factor. Nature 2001;410:940-944
35. Agasse F, Bernardino L, Kristiansen H, et al. Neuropeptide Y promotes neurogenesis in murine subventricular zone. Stem Cells 2008;26:1636-1645
36. Stanic D, Paratcha G, Ledda F, et al. Peptidergic influences on proliferation, migration, and placement of neural progenitors in the adult mouse forebrain. Proc Natl Acad Sci U S A 2008;105:3610-3615 (Pubitemid 351723600)
37. Alvaro AR, Martins J, Araujo IM, et al. Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide. J Neurochem 2008;105:2501-2510 (Pubitemid 351782274)
38. Yang K, Guan H, Arany E, et al. Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor. FASEB J 2008;22:2452-2464 (Pubitemid 351948663)
39. Ruscica M, Dozio E, Boghossian S, et al. Activation of the Y1 receptor by neuropeptide Y regulates the growth of prostate cancer cells. Endocrinology 2006;147:1466-1473 (Pubitemid 43244381)
40. Movafagh S, Hobson JP, Spiegel S, et al. Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. FASEB J 2006;20:1924-1926
41. Erlinge D, Brunkwall J, Edvinsson L. Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP. Regulat Pept 1994;50:259-265 (Pubitemid 24110242)
42. Nilsson T, Edvinsson L. Neuropeptide Y stimulates DNA synthesis in human vascular smooth muscle cells through neuropeptide Y Y1 receptors. Can J Physiol Pharmacol 2000;78:256-259 (Pubitemid 30163459)
43. Ruscica M, Dozio E, Motta M, et al. Relevance of the neuropeptide Y system in the biology of cancer progression. Curr Top Med Chem 2007;7:1682-1691 (Pubitemid 350131005)
44. Parker E, Van Heek M, Stamford A. Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status. Eur J Pharmacol 2002;440:173-187 (Pubitemid 34458022)
45. Shah SH, Freedman N, Zhang L, et al. Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. PLoG Genet 2009;5:e1000318.