The innervation pattern of the human Achilles tendon: Studies of the normal and tendinosis tendon with markers for general and sensory innervation

Cell and Tissue Research

Volumn 320, Issue 1, 2005, Pages 201-206

  Bjur, Dennis ^a   Alfredson, Håkan ^a   Forsgren, Sture ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Achilles tendon; Human; Innervation; Neuropeptides; Tendinosis

Indexed keywords

BIOLOGICAL MARKER; CALCITONIN GENE RELATED PEPTIDE; GENE PRODUCT; GENE PRODUCT 9.5; PROTEIN; PROTEIN SP; SUBSTANCE P; UNCLASSIFIED DRUG;

ACHILLES TENDON; ADULT; ARTICLE; BLOOD VESSEL; CONNECTIVE TISSUE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INNERVATION; MALE; MECHANORECEPTOR; NERVE FIBER; PAIN; PRIORITY JOURNAL; SENSORY NERVE; TENDINITIS; TENDON DISEASE;

ACHILLES TENDON; ADULT; ANTIBODIES; BIOLOGICAL MARKERS; BIOPSY; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; HUMANS; MALE; MIDDLE AGED; SUBSTANCE P; UBIQUITIN THIOLESTERASE;

EID: 17444421516     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-004-1014-3     Document Type: Article

References (17)

1. Ackermann PW, Finn A, Ahmed M (1999) Sensory neuropeptidergic pattern in tendon, ligament and joint capsule. A study in the rat. Neuroreport 13:2055-2060
2. Ackermann PW, Li J, Lundeberg T, Kreicbergs A (2003) Neuronal plasticity in relation to nociception and healing of rat Achilles tendon. J Orthop Res 21:432-441
3. Albuerne M, De Lavallina J, Esteban I, Naves FJ, Silos-Santiago I, Vega JA (2000) Development of Meissner-like and Pacinian sensory corpuscles in the mouse demonstrated with specific markers for corpuscular constituents. Anat Rec 258:235-242
4. Alfredson H, Forsgren S, Thorsen K, Fahlström M, Johansson H, Lorentzon R (2001) Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment? Knee Surg Sports Traumatol Arthrose 9:123-126
5. Alfredson H, Öhberg L, Forsgren S (2003) Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections. Knee Surg Sports Traumatol Arthrosc 11:334-338
6. Andres KH, During M, Schmidt RF (1985) Sensory innervation of the Achilles tendon by group III and IV afferent fibers. Anat Embryol 172:145-156
7. Brain SD (1997) Sensory neuropeptides: their role in inflammation and wound healing. Immunopharmacology 37:133-152
8. Carlton SM, Zhou S, Coggeshall RE (1998) Evidence for the interaction of glutamate and NK-1 receptors in the periphery. Brain Res 790:160-169
9. Cook JL, Feller JA, Bonar SF, Khan KM (2004) Abnormal tenocyte morphology is more prevalent than collagen disruption in asymptomatic athletes' patellar tendons. J Orthop Res 22:334-338
10. Fan T-P D, Hu D-E, Guard S, Gresham GA, Waitling KJ (1993) Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK-1 or interleukin-1 receptor. Br J Pharmacol 110:43-49
11. Halata Z, Wagner C, Baumann KI (1999) Sensory nerve endings in the anterior cruciate ligament (lig. cruciatum anterius) of sheep. Anat Rec 254:13-21
12. Hansson M, Forsgren S (1995) Immunoreactive atrial and brain natriuretic peptides are co-localized in Purkinje fibers but not in the innervation of the bovine heart conduction system. Histochem J 27:222-230
13. Höckerfelt U, Franzén L, Norrgård Ö, Forsgren S (2002) Early increase and later decrease in VIP and substance P nerve fiber densities following abdominal radiotherapy - a study on the human colon. Int J Radiat Biol 78:1045-1053
14. Józsa L, Bálint BJ, Kannus P, Järvinen M, Lehto M (1993) Mechanoreceptors in human myotendinous junction. Muscle Nerve 16:453-457
15. Messner K, Wei Y, Andersson B, Gillqvist J, Rasanen T (1999) Rat model of Achilles tendon disorder. A pilot study. Cells Tissues Organs 165:30-39
16. Öhberg L, Alfredson H (2002) Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med 36:173-177
17. Stilwell DL Jr (1957) The inervation of tendons and aponeurosis. Am J Anat 100:289-317