A multi-species comparative structural bioinformatics analysis of inherited mutations in α-D-mannosidase reveals strong genotype-phenotype correlation

BMC Genomics

Volumn 10, Issue SUPPL. 3, 2009, Pages

  Khan, Javed M ^a   Ranganathan, Shoba ^a,b  

^a MACQUARIE UNIVERSITY   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA MANNOSIDASE; LIGAND;

AMINO ACID SEQUENCE; ARTICLE; CAT; CONTROLLED STUDY; COW; DISEASE SEVERITY; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME STRUCTURE; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; GUINEA PIG; HUMAN; MANNOSIDOSIS; NONHUMAN; PREDICTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SPECIES COMPARISON; STRUCTURAL BIOINFORMATICS; WILD TYPE; X RAY CRYSTALLOGRAPHY; ANIMAL; BIOLOGY; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; GENETICS; GENOTYPE; METABOLISM; MOLECULAR GENETICS; MUTATION; PHENOTYPE; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY;

BOVINAE; CAVIA; MAMMALIA;

ACTIVE SITE; BOUND LIGANDS; CLINICAL MANIFESTATION; COLOCATIONS; DISULFIDE LINKAGES; DISULPHIDE BONDS; ENZYME ACTIVE SITES; GENOTYPIC VARIATIONS; GUINEA PIGS; HOMOLOGY MODELING; HOT SPOT; HOTSPOTS; MAMMALIAN SPECIES; MANNOSIDASE; MULTI-SPECIES; N-LINKED; NON-FUNCTIONAL; PHENOTYPIC EXPRESSION; STRUCTURAL BIOINFORMATICS; STRUCTURAL MAPPING; STRUCTURAL MODELS; WILD TYPES; X-RAY CRYSTALLOGRAPHIC STRUCTURES;

AGRICULTURE; ENZYMES; GENE ENCODING; LIGANDS; MAMMALS; MODEL STRUCTURES; PATHOLOGY; PROTEINS;

BIOINFORMATICS;

ALPHA-MANNOSIDASE; AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CATS; CATTLE; COMPUTATIONAL BIOLOGY; GENOTYPE; GUINEA PIGS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 71549116714     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-10-S3-S33     Document Type: Article

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