Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies

Nanotoxicology

Volumn 3, Issue 4, 2009, Pages 265-275

  Schmoll, Linda H ^a   Elzey, Sherrie ^b   Grassian, Vicki H ^b,c,d   O'Shaughnessy, Patrick T ^a,d  

^a Departments of Civil and Environmental Engineering   (United States)

^b Departments of Chemical and Biochemical Engineering

^c Department of Chemistry ^*

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Aerosol generators; Nanoparticles; Nebulizer

Indexed keywords

NANOPARTICLE; POLYMER; SILICON DIOXIDE; SILVER; SINGLE WALLED NANOTUBE; TITANIUM DIOXIDE;

AEROSOL; ARTICLE; EXPOSURE; MATERIAL COATING; NEBULIZER; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; ULTRASOUND; WATER CONTAMINATION;

EID: 71449097542     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390903121931     Document Type: Article

References (29)

1. American Society for Testing and Materials (ASTM) International. 2006. Terminology for Nanotechnology, E 2456-06, ASTM International. Antonini JM. 2003. Health effects of welding. Crit Rev Toxicol 33(1):61-103.
2. Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI. 2004. Pulmonary responses of mice, rats,and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicolog Sci 77(2):347-357.
3. Davis GS, Leslie KO, Hemenway DR. 1998. Silicosis in mice: Effects of dose, time, and genetic strain. J Environ Pathol Toxicol Oncol. 17(2):81-97.
4. Evans SA, Al-Mosawi A, Adams RA, Berube KA. 2006. Inflammation, edema, and peripheral blood changes in lung-compromised rats after instillation with combustion-derived and manufactured nanoparticles. Exp Lung Res 32(8):363-378.
5. Fischer HC, Chan WC. 2007. Nanotoxicity: The growing need for in vivo study. Curr Opin Biotechnol 18(6):565-571.
6. Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113(11):1555-1560.
7. Grassian VH, O'Shaughnessy PT, Adamcakova-Dodd A, Pettibone JM, Thorne PS. 2007. Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect 115(3):397-402.
8. Hinds WC. 1999. Aerosol technology: Properties, behavior, and measurement of airborne particles. 2nd ed. New York: John Wiley & Sons, Inc.
9. Kim JH, Mulholland GW, Kukuck SR, Pui DYH. 2005. Slip correction measurement of certified PSL nanoparticles using a nanometer differential mobility analyzer (Nano-DMA) for Knudsen number from 0.5 to 83. J Res Nat Inst Stand Technol 110:31-54.
10. LaFranchi BW, Knight M, Petrucci GA. 2003. Leaching as a source of residual particles from nebulisation of deionized water. J Aerosol Sci 34:1589-1594.
11. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V. 2004. Exposure to carbon nanotube material: Aerosol release during the handling of unrefined single walled carbon nanotube material. J Toxicol Environ Health A 67:87-107.
12. Murdock RC, Braydich-Stolle L, Schrand AM, Schlager JJ, Hussain SM. 2007. Characterization of nanomaterial dispersion in solution prior to in vitro exposure using dynamic light scattering technique. Toxicolog Sci 101(2):239-253.
13. Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622-627.
14. Niven RW, Brain JD. 1994. Some functional aspects of air-jet nebulizers. Int J Pharmaceut 104(1):73-85.
15. Oberdörster G. 2000. Toxicology of ultrafine particles: In vivo studies. Philosoph Transact: Math, Phys Engineer Sci 358 (1775):2719-2740.
16. Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H. 2005. Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Particle Fibre Toxicol 2(8).
17. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhalat Toxicol 166-7:437-445.
18. Peters A, Wichmann E, Tuch T, Heinrich J, Heyder J. 1997. Respiratory effects are associated with the number of ultrafine particles. Am J Respirat Crit Care Med 155:1376-1383.
19. Quinlan TR, BéruBé KA, Marsh JP, Janssen YM, Taishi P, Leslie KO, Hemenway D, O'Shaughnessy PT, Vacek P, Mossman BT. 1995. Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos. Am J Pathol Sep 147(3):728-739.
20. Salvi S, Blomberg A, Rudell B, Kelly F, Sandström T, Holgate ST, Frew AJ. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respirat Crit Care Med 159:702-709.
21. Sferlazza SJ, Beckett WS. 1991. The respiratory health of welders. Am Rev Respirat Dis 143(5 Part 1):1134-1148.
22. Thorne PS. 1994. Experimental grain dust atmospheres generated by wet and dry aerosolization techniques. Am J Industr Med 25:109-112.
23. Tran CL, Buchanan D, Cullen RT, Searl A, Jones AD, Donaldson K. 2000. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhalat Toxicol 12(12):11131126.
24. Trust, Science, Innovation (TSI). 2003a. Model 3433 Small-Scale Powder Disperser Instruction Manual. P/N 1933769, Revision E. February 2003.
25. Trust, Science, Innovation (TSI). 2003b. Model 3400A Fluidized Bed Aerosol Generator Instruction Manual. P/N 1933400, Revision I. January 2003.
26. Warheit DB, Webb TR, Reed KL, Frerichs S, Sayes CM. 2007. Pulmonary toxicity study in rats with three forms of ultrafine- TiO2 particles: Differential responses related to surface properties. Toxicology 230(1):90-104.
27. Weyel DA, Ellakkani M, Alarie Y, Karol M. 1984. An aerosol generator for the resuspension of cotton dust. Toxicol Appl Pharmacol 76:544-547.
28. Willeke K, editor. 1980. Generation of aerosols and facilities for exposure experiments. 28 chapters, 597 pages, Ann Arbor, MI: Ann Arbor Science Publishers.
29. Zhu MT, Feng WY, Wang B, Wang TC, Gu YQ, Wang M, Wang Y, Ouyang H, Zhao YL, Chai ZF. 2008. Comparative study of pulmonary responses to nano- and submicron-sized ferric oxide in rats. Toxicology 2472-3:102-111.