A single amino acid substitution converts benzophenone synthase into phenylpyrone synthase

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 30957-30964

  Klundt, Tim ^a   Bocola, Marco ^b,d   Lütge, Maren ^a   Beuerle, Till ^a   Liu, Benye ^a,c   Beerhues, Ludger ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^c INSTITUTE OF BOTANY   (China)

^d UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO ACID SUBSTITUTION; BIOSYNTHETIC PATHWAY; BIOTECHNOLOGICAL TOOLS; CARBON SKELETON; CHEMICAL STRUCTURE; HOMOLOGY MODELING; HYDROGEN-BOND FORMATION; MALONYL-COA; NATURAL PRODUCTS; PHARMACOLOGICAL ACTIVITY; PHENYL MOIETIES; POINT MUTATIONS; POLYKETIDE SYNTHASES; POLYKETIDES; PRODUCT SPECIFICITY; SYNTHASES;

AMINES; AMINO ACIDS; HYDROGEN BONDS; ORGANIC ACIDS;

ENZYMES;

3 HYDROBENZOYL COENZYME A SYNTHASE; BENZOPHENONE SYNTHASE; PHENYLPYRONE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; GUTTIFERAE; HYPERICUM ANDROSAEMUM; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BENZOPHENONES; BINDING SITES; CARBON-CARBON LIGASES; HYPERICUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLANT PROTEINS; POINT MUTATION; SUBSTRATE SPECIFICITY;

EID: 71449089781     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038927     Document Type: Article

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