Structure-based engineering of a plant type III polyketide synthase: Formation of an unnatural nonaketide naphthopyrone

Journal of the American Chemical Society

Volumn 129, Issue 18, 2007, Pages 5976-5980

  Abe, Ikuro ^a,b   Morita, Hiroyuki ^d   Oguro, Satoshi ^a   Noma, Hisashi ^a   Wanibuchi, Kiyofumi ^a   Kawahara, Nobuo ^c   Goda, Yukihiro ^c   Noguchi, Hiroshi ^a   Kohno, Toshiyuki ^d  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^d MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PENTAKETIDE CHROMONE SYNTHASE (PCS); POLYKETIDE SYNTHASE (PKS); SEQUENTIAL CONDENSATIONS; TRIPLE MUTANT;

CONDENSATION; CRYSTAL STRUCTURE; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; PLANTS (BOTANY);

ENZYMES;

MALONYL COENZYME A; NONAKETIDE NAPHTHOPYRONE; POLYKETIDE SYNTHASE; PYRONE DERIVATIVE; UNCLASSIFIED DRUG;

ALOE; ARTICLE; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME STRUCTURE; STRUCTURAL HOMOLOGY; WILD TYPE;

ALOE; AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYKETIDE SYNTHASES; PROTEIN ENGINEERING; PYRONES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 34248526212     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja070375l     Document Type: Article

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