Enzymatic activity of two caspases related to interleukin-1β-converting enzyme

European Journal of Biochemistry

Volumn 253, Issue 1, 1998, Pages 76-83

  Fassy, Florence ^a,c   Krebs, Odile ^a   Rey, Hélène ^a   Komara, Bentou ^a   Gillard, Corinne ^a   Capdevila, Cécile ^a   Yea, Christopher ^b   Faucheu, Chi ^a   Blanchet, Anne Marie ^a   Miossec, Christine ^a   Diu Hercend, Anita ^a  

^a SANOFI   (France)

^b Hoechst Roussel   (United Kingdom)

^c NONE   (France)

Author keywords

Caspase; Cysteine protease; Interleukin 1; Interleukin 1 converting enzyme homolog

Indexed keywords

CASPASE; CYSTEINE PROTEINASE; INTERLEUKIN 1BETA CONVERTING ENZYME; ISOENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACULOVIRUS; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PURIFICATION; GENE CONSTRUCT; HUMAN; IDENTITY; INSECT; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BACULOVIRIDAE; CASPASE 1; CELL LINE; CYSTEINE ENDOPEPTIDASES; HUMANS; INSECTS; INTERLEUKIN-1; KINETICS; OLIGOPEPTIDES; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

ANIMALIA; FELIS CATUS; INSECTA; UNIDENTIFIED BACULOVIRUS;

EID: 7144255525     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2530076.x     Document Type: Article

References (34)

1. Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. ID., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A. & Tocci, M. J. (1992) A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 356, 768 - 774.
2. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. & Horvitz, H. R. (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75, 641 - 652.
3. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong, W. W. & Yuan, J. (1996) Human ICE/CED-3 protease nomenclature. Cell 87, 171.
4. Vincenz, C. & Dixit, V. M. (1997) Fas-associated death domain protein interleukin-1β-converting enzyme 2 (FLICE2). an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling, J. Biol. Chem. 272, 6578 - 6583.
5. Faucheu, C., Diu, A., Chan, A. W. E., Blanchet, A.-M., Miossec, C., Hervé, F., Collart-Dutilleul, V., Gu, Y., Aldape, R. A., Lippke, J. A., Rocher, C., Su, M. S.-S., Livingston, D. J., Hereend, T. & Lalanne, J.-L. (1995) A novel human protease similar to the interleukin-1β converting enzyme induces apoptosis in transfected cells. EMBO J. 14, 1914 - 1922.
6. Kamens, J., Paskind, M., Hugunin, M. Talanian, R. V., Allen, H., Banach, D., Bump, N., Hackett, M., Johnston, C. G., Li, P., Mankovich, J. A., Terranova, M. & Ghayur, T. (1995) Identification and characterisation of ICH-2, a novel member of the interleukin-1β converting enzyme family of cysteine proteases. J. Biol. Chem. 270, 15 250 - 15 256.
7. Munday, N. A., Vaillancourt, J. P., Ali, A., Casano, F. J., Miller, D. K., Molineaux, S. M., Yamin, T.-T. Yu, V. L. & Nicholson, D. W. (1995) Molecular cloning and pro-apoptotic activity of ICEreII and ICEreIII, members of the ICE/CED-3 family of cysteine proteases, J. Biol. Chem. 270. 15 870 - 15 876.
8. Faucheu, C., Blanchet, A.-M., Collard-Dutilleul, V., Lalanne, J.-L. & Diu-Hercend, A. (1996) Identification of cysteine protease closely related to interleukin-1β converting enzyme, Eur. J. Biochem. 236, 207 - 213.
9. Ramage, P., Cheneval, D., Chvei, M., Graff, P., Hemmig, R., Heng, R., Kocher, H. P., Mackenzie, A., Memmert, K., Revesz, L. & Wishart, W. (1995) Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1β converting enzyme precursor, J. Biol. Chem. 270, 9378 - 9383.
10. Criekinge, W. V., Beyaert, R., Van de Craen, M., Vandenabeele, P., Schotte, P., De Valek, D. & Fiers W. (1996) Functional characterization of the prodomain of interleukin-1β converting enzyme, J. Biol. Chem. 271, 27 245 - 27 248.
11. Yamin, T.-T., Ayala, J. M. & Miller, D. K. (1996) Activation of native 45-kDa precursor form of interleukin-1β converting enzyme, J. Biol. Chem. 271, 13 273 - 13 282.
12. Srinivasula, S. M., Fernandes-Alnemri, T., Zangrilli, J., Robertson, N., Armstrong, R. C., Wang, L., Trapani, J. A., Tomaselli, K. J., Litwack, G. & Alnemri, E. S. (1996) The Ced-3/interleukin-1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32, J. Biol. Chem. 271, 27 099 - 27 106.
13. Fernandes-Alnemri, T. Armstrong, R. C., Krebs, J., Srinivasula, S. M., Wang, L., Bullrich, F., Fritz, L. C., Trapani, J. A., Tomaselli, K. J., Litwack, G. & Alnemri, E. S. (1996) In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cystein protease containing two FADD-like domains, Proc. Natl Acad. Sci. USA 93, 7464 - 7469.
14. Muzio, M., Salvesen, G. S. & Dixit, V. M. (1997) FLICE induced apoplosis in a cell-free system, J. Biol. Chem. 272, 2952 - 2956.
15. Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., Wong, W., Kamen, R., Tracey, D. & Allen, H. (1997) Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induecd IFN-γ production. Nature 386, 619-623.
16. Gu, Y. Kuida, K., Tsutsui, H., Ku, G., Hsiao, K., Fleming, M. A., Hayashi, N., Higashino, K., Okamura, H., Nakanishi, K., Kurimoto, M., Tanimoto, T., Flavell, R. A., Sato, V., Harding, M. W., Livingston, D. J. & Su, M. S.-S. (1997) Activation of Interferon-γ inducing factor mediated by interleukin-1β converting enzyme. Science 275, 206 - 209.
17. Wang, X., Pai, J.-T., Wiedenfeld, E. A., Medina, J. C., Slaughter, C. A., Goldstein, J. L. & Brown, M. S. (1995) Purification of an interleukin-1β converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains, J. Biol. Chem. 270, 18 044 - 18 050.
18. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L. & Miller, D. K. (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoplosis, Nature 376, 37 - 43.
19. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. & Earnshaw, W. C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346 - 347.
20. Gu, Y., Sarnecki, C., Aldape, R. A., Livingston, D. J. & Su, M. S.-S. (1995) Cleavage of poly(ADP-ribose) polymerase by interleukin-1β converting enzyme and its homologs TX and Nedd-2, J. Biol. Chem. 270, 18 715 - 18 718.
21. Margolin, N., Raybuck, S. A., Wilson, K. P., Chen, W., Fox, T., Gu, Y. & Livingston, D. J. (1997) Substrate and inhibitor specificity of interleukin-1β converting enzyme and related caspases, J. Biol. Chem. 272, 7223 - 7228.
22. Enari, M., Talanian, R. V. Wong, W. W. & Nagata, S. (1996) Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis, Nature 380, 723 - 726.
23. Wilson, K. P., Black, J.-A. F., Thomson, J. A., Kim, E. F., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A. & Livingston, D. J. (1994) Structure and mechanism of interleukin-1β converting enzyme. Nature 370, 270 - 275.
24. Walker, N. P. C., Talanian, R. V., Brady, K. D., Dang, L. C., Bump, N. J., Ferenz, C. R., Franklin, S., Ghayur, T., Hacken, M. C., Hammill, L. D., Herzog, L., Hugunin, M., Holly, W., Mankovich, J. A., McGuiness, L., Orlewicz, E., Paskind, M., Pratt, C. A., Reis, P., Summani, A., Terranova, M., Welch, J. P., Xiong, L., Möller, A., Tracey, D. F., Kamen, R. & Wong, W. W. (1994) Crystal structure of cysteine protease interleukin-1β, converting enzyme: a (p20/p10)2 homodimer, Cell 78, 343 - 352.
25. Rotonda, J., Nicholson, D. W., Fazil, K. M., Gallant, M., Gareau, Y., Labelle, M., Peterson, E. P., Rasper, D. M., Ruel, R., Vaillancourt, J. P., Thornberry, N. A. & Becker, J. W. (1996) The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat. Struct. Biol. 31, 619 - 625.
26. Mittl, P. R. E., Di Marco, S., Krebs, J. F., Bai, X., Kuranewsky, D. S., Priestle, J. P., Tomaselli, K. J. & Grütter, M. G. (1997) Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone, J. Biol. Chem. 272, 6539 - 6547.
27. Miossec, C., Decoen, M.-C., Durand, L., Fassy, F. & Diu-Hercend, A. (1996) Use of monoclonal antibodies to study interleukin-1β converting enzyme expression: only precursor forms are detected in interleukin-1β-secreting cells, Eur. J. Immunol. 26, 1032 - 1042.
28. Dolle, R. E., Hoyer, D., Prasad, C. V. C., Schmidt, S. J., Helaszek, C. T., Miller, R. E. & Ator, M. A. (1994) Pl aspartate-based peptide α-[(2,6-dichlorobenzoyl)oxy]methyl ketones as potent time-dependent inhibitors of interleukin-1β converting enzyme. J. Med. Chem. 37, 563 - 564.
29. Thornherry, N. A. (1994) Interleukin-1β converting enzyme. Methods Enzymol. 244, 615 - 631.
30. Schlegel, J., Peters, I., Orrenius, S., Miller, D. K., Thornberry, N. A., Yamin, T.-T. & Nicholson, D. W. (1996) CPP32/apopain is a key interleukin-1β, converting enzyme-like protease involved in Fas-mediated apoptosis, J. Biol. Chem. 271, 1841 - 1844.
31. Bertin, J., Mendrysa, S. M., LaCount, D. J., Gaur, S., Krebs, J. F., Armstrong, R. C., Tomaselli, K. J. & Friesen, P. D. (1996) Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease. J. Virol. 70, 6251 - 6259.
32. Ahmad, M., Srinivasula, S. M., Wang, L., Litwack, G., Fernandes-Alnemri, T. & Alnemeri, E. S. (1997) Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein P35, J. Biol. Chem. 272, 1421 - 1424.
33. Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S.-S. & Flavell, R. A. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme, Science 267, 2000 - 2003.
34. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L., Salfeld, J., Towne, E., Tracey, D., Wardwell, S., Wei, F.-Y., Wong, W., Kamen, R. & Seshadri, T. (1995) Mice deficient in IL-1β converting enzyme are detective in production of mature IL-1β and resistant to endotoxic shock, Cell 80, 401 - 411.