XJW20, a novel oxoindole derivative, induces G2/M arrest and apoptosis selectively in K562 leukemia cell line

Chemico-Biological Interactions

Volumn 183, Issue 1, 2010, Pages 133-141

  Ye, Ziqi ^a,b   Chen, Zhe ^a   Chen, Wenteng ^a   Xie, Jinwen ^a   Yang, Hongyu ^a   Lou, Yijia ^a   Yu, Yongping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b First Affiliated Hospital   (China)

Author keywords

Antitumor; Apoptosis; G2 M arrest; K562 cell line; Mitochondrial transmembrane potential; Oxoindole derivate

Indexed keywords

3 (3,4,5 TRIMETHOXYBENZYLIDENE) 5 CARBOETHOXYINDOLIN 2 ONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; ANTINEOPLASTIC AGENT; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; OXOINDOLE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; XJW 20;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL NUCLEUS; CELL STRAIN K 562; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MECHANICS; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASES; CELL DIVISION; CELL LINE; CYCLIN B1; CYTOCHROMES C; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; G2 PHASE; HUMANS; INDOLES; K562 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 71349087231     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.10.015     Document Type: Article

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