Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells

Leukemia Research

Volumn 31, Issue 10, 2007, Pages 1413-1420

  Yang, Sheng Huei ^a   Chien, Ching Ming ^a   Lu, Chih Ming ^a   Chen, Yeh Long ^a   Chang, Long Sen ^b   Lin, Shinne Ren ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

ERK; IQDMA; JNK; K562 cells; p38 MAPK

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CASPASE 8; FAS LIGAND; INDOLOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; N' (11H INDOLO[3,2 C]QUINOLIN 6 YL) N,N DIMETHYLETHANE 1,2 DIAMINE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CULTURE MEDIUM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; LEUKEMIA; LEUKEMIA CELL LINE; PRIORITY JOURNAL; UPREGULATION;

ANTHRACENES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FAS LIGAND PROTEIN; FLOW CYTOMETRY; G2 PHASE; HUMANS; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUINOLINES;

EID: 34547691233     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2007.02.014     Document Type: Article

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