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Volumn 10, Issue 6, 2009, Pages 683-693

Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells

Author keywords

Oxidative stress; Reactive oxygen species; Replicative lifespan; Senescence; Telomerase; Telomere

Indexed keywords

ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CELL POPULATION; CELL SURVIVAL; CHROMOSOME STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; FETUS; FIBROBLAST; GROWTH RATE; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; TELOMERE;

EID: 71349085663     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-009-9216-4     Document Type: Article
Times cited : (22)

References (46)
  • 1
    • 0029156035 scopus 로고
    • Telomere shortening is associated with cell division in vitro and in vivo
    • 10.1006/excr.1995.1306 10.1006/excr.1995.1306 1:CAS:528: DyaK2MXnvVCns70%3D 7664836
    • RC Allsopp, et al. 1995 Telomere shortening is associated with cell division in vitro and in vivo Exp Cell Res 220 194 200 10.1006/excr.1995.1306 10.1006/excr.1995.1306 1:CAS:528:DyaK2MXnvVCns70%3D 7664836
    • (1995) Exp Cell Res , vol.220 , pp. 194-200
    • Allsopp, R.C.1
  • 2
    • 0033427595 scopus 로고    scopus 로고
    • Micronutrient deficiencies. A major cause of DNA damage
    • 10.1111/j.1749-6632.1999.tb08727.x 10.1111/j.1749-6632.1999.tb08727.x 1:CAS:528:DC%2BD3cXnt1Smsw%3D%3D 10668486
    • BN Ames 1999 Micronutrient deficiencies. A major cause of DNA damage Ann N Y Acad Sci 889 87 106 10.1111/j.1749-6632.1999.tb08727.x 10.1111/j.1749-6632. 1999.tb08727.x 1:CAS:528:DC%2BD3cXnt1Smsw%3D%3D 10668486
    • (1999) Ann N y Acad Sci , vol.889 , pp. 87-106
    • Ames, B.N.1
  • 3
    • 17344390525 scopus 로고    scopus 로고
    • N-t-butyl hydroxylamine, a hydrolysis product of α-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts
    • DOI 10.1074/jbc.275.10.6741
    • H Atamna A Paler-Martinez BN Ames 2000 n-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-n-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts J Biol Chem 275 6741 6748 10.1074/jbc.275.10.6741 10.1074/jbc.275.10.6741 1:CAS:528:DC%2BD3cXhvVGksbo%3D 10702229 (Pubitemid 30146210)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.10 , pp. 6741-6748
    • Atamna, H.1    Paler-Martinez, A.2    Ames, B.N.3
  • 4
    • 20144363986 scopus 로고    scopus 로고
    • New developments in telomere length analysis
    • DOI 10.1016/j.exger.2005.02.008, PII S0531556505000367
    • DM Baird 2005 New developments in telomere length analysis Exp Gerontol 40 363 368 10.1016/j.exger.2005.02.008 10.1016/j.exger.2005.02.008 1:CAS:528:DC%2BD2MXks1Wgtbg%3D 15919587 (Pubitemid 40775728)
    • (2005) Experimental Gerontology , vol.40 , Issue.5 , pp. 363-368
    • Baird, D.M.1
  • 5
    • 36749019586 scopus 로고    scopus 로고
    • Telomere dynamics in human cells
    • DOI 10.1016/j.biochi.2007.08.003, PII S0300908407002052, Telomeres and Telomerase: from Basic Research to Clinical Applications
    • DM Baird 2008 Telomere dynamics in human cells Biochimie 90 116 121 10.1016/j.biochi.2007.08.003 10.1016/j.biochi.2007.08.003 1:CAS:528: DC%2BD2sXhsVSqu7rJ 17854970 (Pubitemid 350216213)
    • (2008) Biochimie , vol.90 , Issue.1 , pp. 116-121
    • Baird, D.M.1
  • 6
    • 0037313185 scopus 로고    scopus 로고
    • Extensive allelic variation and ultrashort telomeres in senescent human cells
    • DOI 10.1038/ng1084
    • DM Baird J Rowson D Wynford-Thomas D Kipling 2003 Extensive allelic variation and ultrashort telomeres in senescent human cells Nat Genet 33 203 207 10.1038/ng1084 10.1038/ng1084 1:CAS:528:DC%2BD3sXnsFSkuw%3D%3D 12539050 (Pubitemid 36177075)
    • (2003) Nature Genetics , vol.33 , Issue.2 , pp. 203-207
    • Baird, D.M.1    Rowson, J.2    Wynford-Thomas, D.3    Kipling, D.4
  • 7
    • 3543130605 scopus 로고    scopus 로고
    • Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells
    • DOI 10.1093/hmg/ddh159
    • DM Baird T Davis J Rowson CJ Jones D Kipling 2004 Normal telomere erosion rates at the single cell level in Werner syndrome fibroblast cells Hum Mol Genet 13 1515 1524 10.1093/hmg/ddh159 10.1093/hmg/ddh159 1:CAS:528: DC%2BD2cXlt1Wls7k%3D 15150162 (Pubitemid 39023059)
    • (2004) Human Molecular Genetics , vol.13 , Issue.14 , pp. 1515-1524
    • Baird, D.M.1    Davis, T.2    Rowson, J.3    Jones, C.J.4    Kipling, D.5
  • 9
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • DOI 10.1016/j.cell.2005.02.001
    • RS Balaban S Nemoto T Finkel 2005 Mitochondria, oxidants, and aging Cell 120 483 495 10.1016/j.cell.2005.02.001 10.1016/j.cell.2005.02.001 1:CAS:528:DC%2BD2MXitVWnurg%3D 15734681 (Pubitemid 40269763)
    • (2005) Cell , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 10
    • 0017738651 scopus 로고
    • The effect of oxygen and vitamin e on the lifespan of human diploid cells in vitro
    • 10.1083/jcb.74.1.58 10.1083/jcb.74.1.58 1:CAS:528:DyaE2sXktF2ltrs%3D 874002
    • AK Balin DB Goodman H Rasmussen VJ Cristofalo 1977 The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro J Cell Biol 74 58 67 10.1083/jcb.74.1.58 10.1083/jcb.74.1.58 1:CAS:528:DyaE2sXktF2ltrs%3D 874002
    • (1977) J Cell Biol , vol.74 , pp. 58-67
    • Balin, A.K.1    Goodman, D.B.2    Rasmussen, H.3    Cristofalo, V.J.4
  • 11
    • 0141866708 scopus 로고    scopus 로고
    • Superoxide dismutase 1 knock-down induces senescence in human fibroblasts
    • DOI 10.1074/jbc.M307146200
    • G Blander RM de Oliveira CM Conboy M Haigis L Guarente 2003 Superoxide dismutase 1 knock-down induces senescence in human fibroblasts J Biol Chem 278 38966 38969 10.1074/jbc.M307146200 10.1074/jbc.M307146200 1:CAS:528: DC%2BD3sXnslWjtrk%3D 12871978 (Pubitemid 37221797)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.40 , pp. 38966-38969
    • Blander, G.1    De Oliveira, R.M.2    Conboy, C.M.3    Haigis, M.4    Guarente, L.5
  • 12
    • 0029841549 scopus 로고    scopus 로고
    • Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
    • 1:CAS:528:DyaK28XnsFait7s%3D 8950976
    • J Bond M Haughton J Blaydes V Gire D Wynford-Thomas F Wyllie 1996 Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence Oncogene 13 2097 2104 1:CAS:528: DyaK28XnsFait7s%3D 8950976
    • (1996) Oncogene , vol.13 , pp. 2097-2104
    • Bond, J.1    Haughton, M.2    Blaydes, J.3    Gire, V.4    Wynford-Thomas, D.5    Wyllie, F.6
  • 13
    • 33144456602 scopus 로고    scopus 로고
    • Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans
    • DOI 10.1093/hmg/ddi486
    • B Britt-Compton J Rowson M Locke I Mackenzie D Kipling DM Baird 2006 Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans Hum Mol Genet 15 725 733 10.1093/hmg/ddi486 10.1093/hmg/ddi486 1:CAS:528:DC%2BD28XhsF2mtbs%3D 16421168 (Pubitemid 43264697)
    • (2006) Human Molecular Genetics , vol.15 , Issue.5 , pp. 725-733
    • Britt-Compton, B.1    Rowson, J.2    Locke, M.3    Mackenzie, I.4    Kipling, D.5    Baird, D.M.6
  • 15
    • 0029051426 scopus 로고
    • Oxidative DNA damage and senescence of human diploid fibroblast cells
    • 10.1073/pnas.92.10.4337 10.1073/pnas.92.10.4337 1:CAS:528: DyaK2MXls1alu78%3D 7753808
    • Q Chen A Fischer JD Reagan LJ Yan BN Ames 1995 Oxidative DNA damage and senescence of human diploid fibroblast cells Proc Natl Acad Sci USA 92 4337 4341 10.1073/pnas.92.10.4337 10.1073/pnas.92.10.4337 1:CAS:528:DyaK2MXls1alu78%3D 7753808
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4337-4341
    • Chen, Q.1    Fischer, A.2    Reagan, J.D.3    Yan, L.J.4    Ames, B.N.5
  • 16
    • 0035325264 scopus 로고    scopus 로고
    • Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts
    • DOI 10.1006/excr.2001.5182
    • QM Chen KR Prowse VC Tu S Purdom MH Linskens 2001 Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts Exp Cell Res 265 294 303 10.1006/excr.2001.5182 10.1006/excr.2001. 5182 1:CAS:528:DC%2BD3MXis1ertrk%3D 11302695 (Pubitemid 32980218)
    • (2001) Experimental Cell Research , vol.265 , Issue.2 , pp. 294-303
    • Chen, Q.M.1    Prowse, K.R.2    Tu, V.C.3    Purdom, S.4    Linskens, M.H.K.5
  • 17
    • 0035943348 scopus 로고    scopus 로고
    • Synergy between ascorbate and α-tocopherol on fibroblasts in culture
    • DOI 10.1016/S0024-3205(01)01240-1, PII S0024320501012401
    • T Chepda, et al. 2001 Synergy between ascorbate and alpha-tocopherol on fibroblasts in culture Life Sci 69 1587 1596 10.1016/S0024-3205(01)01240-1 10.1016/S0024-3205(01)01240-1 1:CAS:528:DC%2BD3MXmsFOisb0%3D 11589499 (Pubitemid 32800638)
    • (2001) Life Sciences , vol.69 , Issue.14 , pp. 1587-1596
    • Chepda, T.1    Cadau, M.2    Lassabliere, F.3    Reynaud, E.4    Perier, C.5    Frey, J.6    Chamson, A.7
  • 19
    • 0037125201 scopus 로고    scopus 로고
    • Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts
    • DOI 10.1016/S0014-5793(02)02973-3, PII S0014579302029733
    • JP de Magalhaes F Chainiaux J Remacle O Toussaint 2002 Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts FEBS Lett 523 157 162 10.1016/S0014-5793(02)02973-3 12123824 (Pubitemid 34786078)
    • (2002) FEBS Letters , vol.523 , Issue.1-3 , pp. 157-162
    • De Magalhaes, J.P.1    Chainiaux, F.2    Remacle, J.3    Toussaint, O.4
  • 21
    • 0035800610 scopus 로고    scopus 로고
    • Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence
    • DOI 10.1016/S0014-5793(01)02679-5, PII S0014579301026795
    • P Dumont, et al. 2001 Growth kinetics rather than stress accelerate telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence FEBS Lett 502 109 112 10.1016/S0014-5793(01) 02679-5 1:CAS:528:DC%2BD3MXlslGgurs%3D 11583109 (Pubitemid 32728270)
    • (2001) FEBS Letters , vol.502 , Issue.3 , pp. 109-112
    • Dumont, P.1    Royer, V.2    Pascal, T.3    Dierick, J.-F.4    Chainiaux, F.5    Frippiat, C.6    De Magalhaes, J.P.7    Eliaers, F.8    Remacle, J.9    Toussaint, O.10
  • 22
    • 34247581288 scopus 로고    scopus 로고
    • Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
    • DOI 10.1016/j.ccr.2007.02.026, PII S1535610807000876
    • DM Feldser CW Greider 2007 Short telomeres limit tumor progression in vivo by inducing senescence Cancer Cell 11 461 469 10.1016/j.ccr.2007.02.026 1:CAS:528:DC%2BD2sXlsVagsrw%3D 17433785 (Pubitemid 46670077)
    • (2007) Cancer Cell , vol.11 , Issue.5 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 23
    • 2142666372 scopus 로고    scopus 로고
    • Developmental differences in the immortalization of lung fibroblasts by telomerase
    • 10.1046/j.1474-9728.2003.00057.x 1:CAS:528:DC%2BD3sXot1WltLw%3D 14570231
    • NR Forsyth AP Evans JW Shay WE Wright 2003 Developmental differences in the immortalization of lung fibroblasts by telomerase Aging Cell 2 235 243 10.1046/j.1474-9728.2003.00057.x 1:CAS:528:DC%2BD3sXot1WltLw%3D 14570231
    • (2003) Aging Cell , vol.2 , pp. 235-243
    • Forsyth, N.R.1    Evans, A.P.2    Shay, J.W.3    Wright, W.E.4
  • 24
    • 0037064011 scopus 로고    scopus 로고
    • Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
    • DOI 10.1074/jbc.M202671200
    • V Gorbunova A Seluanov OM Pereira-Smith 2002 Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis J Biol Chem 277 38540 38549 10.1074/jbc.M202671200 1:CAS:528:DC%2BD38Xns1Cntr8%3D 12140282 (Pubitemid 35154713)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 38540-38549
    • Gorbunova, V.1    Seluanov, A.2    Pereira-Smith, O.M.3
  • 25
    • 0032823769 scopus 로고    scopus 로고
    • Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
    • DOI 10.1080/10715769900300841
    • B Halliwell 1999 Antioxidant defence mechanisms: from the beginning to the end (of the beginning) Free Radic Res 31 261 272 10.1080/10715769900300841 1:CAS:528:DyaK1MXmslGjsL4%3D 10517532 (Pubitemid 29452853)
    • (1999) Free Radical Research , vol.31 , Issue.4 , pp. 261-272
    • Halliwell, B.1
  • 26
    • 0037430971 scopus 로고    scopus 로고
    • Oxidative stress in cell culture: An under-appreciated problem?
    • DOI 10.1016/S0014-5793(03)00235-7
    • B Halliwell 2003 Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett 540 3 6 10.1016/S0014-5793(03)00235-7 1:CAS:528: DC%2BD3sXislCitLo%3D 12681474 (Pubitemid 36398024)
    • (2003) FEBS Letters , vol.540 , Issue.1-3 , pp. 3-6
    • Halliwell, B.1
  • 27
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • DOI 10.1038/345458a0
    • CB Harley AB Futcher CW Greider 1990 Telomeres shorten during ageing of human fibroblasts Nature 345 458 460 10.1038/345458a0 1:CAS:528: DyaK3cXksFKntb4%3D 2342578 (Pubitemid 20178256)
    • (1990) Nature , vol.345 , Issue.6274 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 28
    • 0026628668 scopus 로고
    • The telomere hypothesis of cellular aging
    • 10.1016/0531-5565(92)90068-B 1:CAS:528:DyaK38XmtlSlsbg%3D 1459213
    • CB Harley H Vaziri CM Counter RC Allsopp 1992 The telomere hypothesis of cellular aging Exp Gerontol 27 375 382 10.1016/0531-5565(92)90068-B 1:CAS:528:DyaK38XmtlSlsbg%3D 1459213
    • (1992) Exp Gerontol , vol.27 , pp. 375-382
    • Harley, C.B.1    Vaziri, H.2    Counter, C.M.3    Allsopp, R.C.4
  • 29
    • 33644692330 scopus 로고    scopus 로고
    • Cellular senescence in aging primates
    • DOI 10.1126/science.1122446
    • U Herbig M Ferreira L Condel D Carey JM Sedivy 2006 Cellular senescence in aging primates Science 311 1257 10.1126/science.1122446 1:CAS:528: DC%2BD28XitV2hsbk%3D 16456035 (Pubitemid 43334708)
    • (2006) Science , vol.311 , Issue.5765 , pp. 1257
    • Herbig, U.1    Ferreira, M.2    Condel, L.3    Carey, D.4    Sedivy, J.M.5
  • 30
    • 0142075332 scopus 로고    scopus 로고
    • Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells
    • DOI 10.1016/S0891-5849(03)00326-5
    • G Kashino, et al. 2003 Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells Free Radic Biol Med 35 438 443 10.1016/S0891-5849(03)00326-5 1:CAS:528: DC%2BD3sXlvFynsr4%3D 12899945 (Pubitemid 37289173)
    • (2003) Free Radical Biology and Medicine , vol.35 , Issue.4 , pp. 438-443
    • Kashino, G.1    Kodama, S.2    Nakayama, Y.3    Suzuki, K.4    Fukase, K.5    Goto, M.6    Watanabe, M.7
  • 31
    • 0028295472 scopus 로고
    • The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture
    • 1:CAS:528:DyaK2cXltVentrY%3D 7911472
    • IR Kill RG Faragher K Lawrence S Shall 1994 The expression of proliferation-dependent antigens during the lifespan of normal and progeroid human fibroblasts in culture J Cell Sci 107 Pt 2 571 579 1:CAS:528: DyaK2cXltVentrY%3D 7911472
    • (1994) J Cell Sci , vol.107 , Issue.PART 2 , pp. 571-579
    • Kill, I.R.1    Faragher, R.G.2    Lawrence, K.3    Shall, S.4
  • 32
    • 0035063440 scopus 로고    scopus 로고
    • Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus
    • 1:CAS:528:DC%2BD3MXisFWms7s%3D 11257191
    • BP McSharry CJ Jones JW Skinner D Kipling GW Wilkinson 2001 Human telomerase reverse transcriptase-immortalized MRC-5 and HCA2 human fibroblasts are fully permissive for human cytomegalovirus J Gen Virol 82 855 863 1:CAS:528:DC%2BD3MXisFWms7s%3D 11257191
    • (2001) J Gen Virol , vol.82 , pp. 855-863
    • McSharry, B.P.1    Jones, C.J.2    Skinner, J.W.3    Kipling, D.4    Wilkinson, G.W.5
  • 33
    • 0035858987 scopus 로고    scopus 로고
    • Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
    • DOI 10.1038/sj.onc.1204460
    • J Munro K Steeghs V Morrison H Ireland EK Parkinson 2001 Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres Oncogene 20 3541 3552 10.1038/sj.onc.1204460 1:CAS:528:DC%2BD3MXkvValsLw%3D 11429701 (Pubitemid 32619407)
    • (2001) Oncogene , vol.20 , Issue.27 , pp. 3541-3552
    • Munro, J.1    Steeghs, K.2    Morrison, V.3    Ireland, H.4    Parkinson, E.K.5
  • 35
    • 0017405185 scopus 로고
    • Low oxygen concentration extends the lifespan of cultured human diploid cells
    • L Packer K Fuehr 1977 Low oxygen concentration extends the lifespan of cultured human diploid cells Nature 267 423 425 10.1038/267423a0 1:CAS:528:DyaE2sXltlWnsb4%3D 876356 (Pubitemid 8105518)
    • (1977) Nature , vol.267 , Issue.5610 , pp. 423-425
    • Packer, L.1    Fuehr, L.2
  • 36
    • 0016362593 scopus 로고
    • Extension of the lifespan of cultured normal human diploid cells by vitamin e
    • 10.1073/pnas.71.12.4763 1:CAS:528:DyaE2MXotlyitw%3D%3D 4531015
    • L Packer JR Smith 1974 Extension of the lifespan of cultured normal human diploid cells by vitamin E Proc Natl Acad Sci USA 71 4763 4767 10.1073/pnas.71.12.4763 1:CAS:528:DyaE2MXotlyitw%3D%3D 4531015
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 4763-4767
    • Packer, L.1    Smith, J.R.2
  • 38
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • 10.1038/sj.onc.1201862 1:CAS:528:DyaK1cXhvV2lt7k%3D 9528853
    • SJ Robles GR Adami 1998 Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts Oncogene 16 1113 1123 10.1038/sj.onc.1201862 1:CAS:528:DyaK1cXhvV2lt7k%3D 9528853
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 40
    • 0028915601 scopus 로고
    • The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives
    • 10.1006/excr.1995.1087 1:CAS:528:DyaK2MXkslyrsb0%3D 7698226
    • H Saito AT Hammond RE Moses 1995 The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives Exp Cell Res 217 272 279 10.1006/excr.1995.1087 1:CAS:528:DyaK2MXkslyrsb0%3D 7698226
    • (1995) Exp Cell Res , vol.217 , pp. 272-279
    • Saito, H.1    Hammond, A.T.2    Moses, R.E.3
  • 41
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
    • DOI 10.1016/S0092-8674(00)81902-9
    • M Serrano AW Lin ME McCurrach D Beach SW Lowe 1997 Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88 593 602 10.1016/S0092-8674(00)81902-9 1:CAS:528:DyaK2sXhvVSit7k%3D 9054499 (Pubitemid 27152402)
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 44
    • 0036629255 scopus 로고    scopus 로고
    • Oxidative stress shortens telomeres
    • DOI 10.1016/S0968-0004(02)02110-2, PII S0968000402021102
    • T von Zglinicki 2002 Oxidative stress shortens telomeres Trends Biochem Sci 27 339 344 10.1016/S0968-0004(02)02110-2 (Pubitemid 34756516)
    • (2002) Trends in Biochemical Sciences , vol.27 , Issue.7 , pp. 339-344
    • Von Zglinicki, T.1
  • 45
    • 0029127226 scopus 로고
    • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
    • 10.1006/excr.1995.1305
    • T von Zglinicki G Saretzki W Docke C Lotze 1995 Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 220 186 193 10.1006/excr.1995.1305
    • (1995) Exp Cell Res , vol.220 , pp. 186-193
    • Von Zglinicki, T.1    Saretzki, G.2    Docke, W.3    Lotze, C.4
  • 46
    • 16644389204 scopus 로고    scopus 로고
    • Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress
    • DOI 10.1002/jcb.20208
    • S Yokoo K Furumoto E Hiyama N Miwa 2004 Slow-down of age-dependent telomere shortening is executed in human skin keratinocytes by hormesis-like-effects of trace hydrogen peroxide or by anti-oxidative effects of pro-vitamin C in common concurrently with reduction of intracellular oxidative stress J Cell Biochem 93 588 597 10.1002/jcb.20208 1:CAS:528: DC%2BD2cXosVyqs7Y%3D 15378602 (Pubitemid 44264193)
    • (2004) Journal of Cellular Biochemistry , vol.93 , Issue.3 , pp. 588-597
    • Yokoo, S.1    Furumoto, K.2    Hiyama, E.3    Miwa, N.4


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