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Volumn 85, Issue 6, 2009, Pages 823-832

Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

EID: 71149086939     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajhg.2009.10.028     Document Type: Article
Times cited : (200)

References (50)
  • 1
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C.B., Futcher A.B., and Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345 (1990) 458-460
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 3
    • 0031799895 scopus 로고    scopus 로고
    • X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
    • Heiss N.S., Knight S.W., Vulliamy T.J., Klauck S.M., Wiemann S., Mason P.J., Poustka A., and Dokal I. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat. Genet. 19 (1998) 32-38
    • (1998) Nat. Genet. , vol.19 , pp. 32-38
    • Heiss, N.S.1    Knight, S.W.2    Vulliamy, T.J.3    Klauck, S.M.4    Wiemann, S.5    Mason, P.J.6    Poustka, A.7    Dokal, I.8
  • 4
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell J.R., Wood E., and Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402 (1999) 551-555
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 6
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P.J., and Dokal I. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413 (2001) 432-435
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1    Marrone, A.2    Goldman, F.3    Dearlove, A.4    Bessler, M.5    Mason, P.J.6    Dokal, I.7
  • 7
    • 2442617343 scopus 로고    scopus 로고
    • Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC
    • Vulliamy T., Marrone A., Szydlo R., Walne A., Mason P.J., and Dokal I. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat. Genet. 36 (2004) 447-449
    • (2004) Nat. Genet. , vol.36 , pp. 447-449
    • Vulliamy, T.1    Marrone, A.2    Szydlo, R.3    Walne, A.4    Mason, P.J.5    Dokal, I.6
  • 8
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison S.J., Prowse K.R., Ho P., and Weissman I.L. Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity 5 (1996) 207-216
    • (1996) Immunity , vol.5 , pp. 207-216
    • Morrison, S.J.1    Prowse, K.R.2    Ho, P.3    Weissman, I.L.4
  • 9
    • 0029940570 scopus 로고    scopus 로고
    • Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow
    • Chiu C.P., Dragowska W., Kim N.W., Vaziri H., Yui J., Thomas T.E., Harley C.B., and Lansdorp P.M. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells 14 (1996) 239-248
    • (1996) Stem Cells , vol.14 , pp. 239-248
    • Chiu, C.P.1    Dragowska, W.2    Kim, N.W.3    Vaziri, H.4    Yui, J.5    Thomas, T.E.6    Harley, C.B.7    Lansdorp, P.M.8
  • 13
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    • Herrera E., Samper E., Martin-Caballero J., Flores J.M., Lee H.W., and Blasco M.A. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18 (1999) 2950-2960
    • (1999) EMBO J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.W.5    Blasco, M.A.6
  • 14
    • 0025029030 scopus 로고
    • Hypervariable ultra-long telomeres in mice
    • Kipling D., and Cooke H.J. Hypervariable ultra-long telomeres in mice. Nature 347 (1990) 400-402
    • (1990) Nature , vol.347 , pp. 400-402
    • Kipling, D.1    Cooke, H.J.2
  • 15
    • 28944455294 scopus 로고    scopus 로고
    • Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
    • Hao L.Y., Armanios M., Strong M.A., Karim B., Feldser D.M., Huso D., and Greider C.W. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123 (2005) 1121-1131
    • (2005) Cell , vol.123 , pp. 1121-1131
    • Hao, L.Y.1    Armanios, M.2    Strong, M.A.3    Karim, B.4    Feldser, D.M.5    Huso, D.6    Greider, C.W.7
  • 16
    • 0034669532 scopus 로고    scopus 로고
    • Wild-derived inbred mouse strains have short telomeres
    • Hemann M.T., and Greider C.W. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res. 28 (2000) 4474-4478
    • (2000) Nucleic Acids Res. , vol.28 , pp. 4474-4478
    • Hemann, M.T.1    Greider, C.W.2
  • 18
    • 40849093093 scopus 로고    scopus 로고
    • The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase
    • Makovets S., Williams T.L., and Blackburn E.H. The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase. Genetics 178 (2008) 245-257
    • (2008) Genetics , vol.178 , pp. 245-257
    • Makovets, S.1    Williams, T.L.2    Blackburn, E.H.3
  • 20
    • 32044458462 scopus 로고    scopus 로고
    • Platelet counts differ by sex, ethnicity, and age in the United States
    • Segal J.B., and Moliterno A.R. Platelet counts differ by sex, ethnicity, and age in the United States. Ann. Epidemiol. 16 (2006) 123-130
    • (2006) Ann. Epidemiol. , vol.16 , pp. 123-130
    • Segal, J.B.1    Moliterno, A.R.2
  • 21
    • 76549194326 scopus 로고
    • Normal Variations With Aging Of The Amount Of Hematopoietic Tissue In Bone Marrow From The Anterior Iliac Crest. A Study Made From 177 Cases Of Sudden Death Examined By Necropsy
    • Hartsock R.J., Smith E.B., and Petty C.S. Normal Variations With Aging Of The Amount Of Hematopoietic Tissue In Bone Marrow From The Anterior Iliac Crest. A Study Made From 177 Cases Of Sudden Death Examined By Necropsy. Am. J. Clin. Pathol. 43 (1965) 326-331
    • (1965) Am. J. Clin. Pathol. , vol.43 , pp. 326-331
    • Hartsock, R.J.1    Smith, E.B.2    Petty, C.S.3
  • 23
    • 0035975704 scopus 로고    scopus 로고
    • Does functional depletion of stem cells drive aging?
    • Schlessinger D., and Van Zant G. Does functional depletion of stem cells drive aging?. Mech. Ageing Dev. 122 (2001) 1537-1553
    • (2001) Mech. Ageing Dev. , vol.122 , pp. 1537-1553
    • Schlessinger, D.1    Van Zant, G.2
  • 24
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel M.J., Yilmaz O.H., Iwashita T., Terhorst C., and Morrison S.J. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121 (2005) 1109-1121
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Terhorst, C.4    Morrison, S.J.5
  • 25
    • 31544481865 scopus 로고    scopus 로고
    • SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity
    • Yilmaz O.H., Kiel M.J., and Morrison S.J. SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood 107 (2006) 924-930
    • (2006) Blood , vol.107 , pp. 924-930
    • Yilmaz, O.H.1    Kiel, M.J.2    Morrison, S.J.3
  • 26
    • 11244310960 scopus 로고    scopus 로고
    • Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita
    • Knudson M., Kulkarni S., Ballas Z.K., Bessler M., and Goldman F. Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita. Blood 105 (2005) 682-688
    • (2005) Blood , vol.105 , pp. 682-688
    • Knudson, M.1    Kulkarni, S.2    Ballas, Z.K.3    Bessler, M.4    Goldman, F.5
  • 27
    • 33646546302 scopus 로고    scopus 로고
    • Aging of the immune system: how much can the adaptive immune system adapt?
    • Weng N.P. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 24 (2006) 495-499
    • (2006) Immunity , vol.24 , pp. 495-499
    • Weng, N.P.1
  • 28
    • 0026499013 scopus 로고
    • Another case of Pneumocystis carinii pneumonia in a patient with dyskeratosis congenita (Zinsser-Cole-Engman syndrome)
    • Rose C., and Kern W.V. Another case of Pneumocystis carinii pneumonia in a patient with dyskeratosis congenita (Zinsser-Cole-Engman syndrome). Clin. Infect. Dis. 15 (1992) 1056-1057
    • (1992) Clin. Infect. Dis. , vol.15 , pp. 1056-1057
    • Rose, C.1    Kern, W.V.2
  • 30
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., and Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361 (2003) 393-395
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 31
    • 0029894199 scopus 로고    scopus 로고
    • Regulated expression of telomerase activity in human T lymphocyte development and activation
    • Weng N.P., Levine B.L., June C.H., and Hodes R.J. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183 (1996) 2471-2479
    • (1996) J. Exp. Med. , vol.183 , pp. 2471-2479
    • Weng, N.P.1    Levine, B.L.2    June, C.H.3    Hodes, R.J.4
  • 32
    • 0029810884 scopus 로고    scopus 로고
    • Telomerase regulation during entry into the cell cycle in normal human T cells
    • Buchkovich K.J., and Greider C.W. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol. Biol. Cell 7 (1996) 1443-1454
    • (1996) Mol. Biol. Cell , vol.7 , pp. 1443-1454
    • Buchkovich, K.J.1    Greider, C.W.2
  • 34
    • 0036677405 scopus 로고    scopus 로고
    • MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae
    • Enomoto S., Glowczewski L., and Berman J. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol. Biol. Cell 13 (2002) 2626-2638
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2626-2638
    • Enomoto, S.1    Glowczewski, L.2    Berman, J.3
  • 35
    • 0037341611 scopus 로고    scopus 로고
    • Short telomeres induce a DNA damage response in Saccharomyces cerevisiae
    • IJpma A.S., and Greider C.W. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae. Mol. Biol. Cell 14 (2003) 987-1001
    • (2003) Mol. Biol. Cell , vol.14 , pp. 987-1001
    • IJpma, A.S.1    Greider, C.W.2
  • 36
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., and DePinho R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 (2000) 641-645
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 39
    • 0034978564 scopus 로고    scopus 로고
    • Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
    • Rudolph K.L., Millard M., Bosenberg M.W., and DePinho R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28 (2001) 155-159
    • (2001) Nat. Genet. , vol.28 , pp. 155-159
    • Rudolph, K.L.1    Millard, M.2    Bosenberg, M.W.3    DePinho, R.A.4
  • 40
  • 41
    • 0346995285 scopus 로고    scopus 로고
    • Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis
    • Qi L., Strong M.A., Karim B.O., Armanios M., Huso D.L., and Greider C.W. Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis. Cancer Res. 63 (2003) 8188-8196
    • (2003) Cancer Res. , vol.63 , pp. 8188-8196
    • Qi, L.1    Strong, M.A.2    Karim, B.O.3    Armanios, M.4    Huso, D.L.5    Greider, C.W.6
  • 42
    • 34247581288 scopus 로고    scopus 로고
    • Short telomeres limit tumor progression in vivo by inducing senescence
    • Feldser D.M., and Greider C.W. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11 (2007) 461-469
    • (2007) Cancer Cell , vol.11 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 43
    • 36248952723 scopus 로고    scopus 로고
    • Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
    • Guo X., Deng Y., Lin Y., Cosme-Blanco W., Chan S., He H., Yuan G., Brown E.J., and Chang S. Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J. 26 (2007) 4709-4719
    • (2007) EMBO J. , vol.26 , pp. 4709-4719
    • Guo, X.1    Deng, Y.2    Lin, Y.3    Cosme-Blanco, W.4    Chan, S.5    He, H.6    Yuan, G.7    Brown, E.J.8    Chang, S.9
  • 44
    • 0242354776 scopus 로고    scopus 로고
    • Dyskeratosis congenita: its link to telomerase and aplastic anaemia
    • Dokal I., and Vulliamy T. Dyskeratosis congenita: its link to telomerase and aplastic anaemia. Blood Rev. 17 (2003) 217-225
    • (2003) Blood Rev. , vol.17 , pp. 217-225
    • Dokal, I.1    Vulliamy, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.